专利检索 ap:("Joon Haeng Rhee" OR "Shee Eun Lee" OR "Soo Young Kim") AND inv:"Shee Eun Lee" 第 1 页

1.

发明申请
MODIFIED FLAGELLIN IMPROVED TOLL-LIKE RECEPTOR 5 STIMULATING ACTIVITY 有权
标题翻译：改良的FLAGELLIN改进的TOLL-LIKE受体5刺激活性

公开(公告)号：US20110008378A1

公开(公告)日：2011-01-13

申请号：US12526187

申请日：2008-02-05

申请人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim

发明人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim

IPC分类号： A61K39/106 , C07K14/28 , A61P37/04 , A61P31/04

CPC分类号： C07K14/28

摘要： Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.

摘要翻译： 本文公开了具有增强的刺激长耳状受体-5的活性的鞭毛蛋白突变体（以下称为“TLR5”）。更具体地，公开了通过点突变TRL5激动剂鞭毛蛋白的一些氨基酸制备的鞭毛蛋白突变体，以增强鞭毛蛋白的TRL刺激活性。

2.

发明授权
Modified flagellin improved toll-like receptor 5 stimulating activity 有权
标题翻译：改良的鞭毛蛋白改善了toll样受体5刺激活性

公开(公告)号：US08337864B2

公开(公告)日：2012-12-25

申请号：US13333709

申请日：2011-12-21

申请人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim

发明人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim

IPC分类号： A61K39/106

CPC分类号： C07K14/28

摘要： Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.

摘要翻译： 本文公开了具有增强的刺激长耳状受体-5（以下称为TLR5）的活性的鞭毛蛋白突变体。更具体地，公开了通过点突变TRL5激动剂鞭毛蛋白的一些氨基酸制备的鞭毛蛋白突变体，以增强鞭毛蛋白的TRL刺激活性。

3.

发明授权
Modified flagellin improved toll-like receptor 5 stimulating activity 有权

公开(公告)号：US08337865B2

公开(公告)日：2012-12-25

申请号：US13333857

申请日：2011-12-21

申请人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim

发明人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim

IPC分类号： A61K39/106

CPC分类号： C07K14/28

摘要： Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.

4.

发明授权
Modified flagellin improved toll-like receptor 5 stimulating activity 有权
标题翻译：改良的鞭毛蛋白改善了toll样受体5刺激活性

公开(公告)号：US08236327B2

公开(公告)日：2012-08-07

申请号：US12526187

申请日：2009-08-06

申请人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim

发明人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim

IPC分类号： A61K39/106

CPC分类号： C07K14/28

摘要： Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.

摘要翻译： 本文公开了具有增强的刺激长耳状受体-5的活性的鞭毛蛋白突变体（以下称为“TLR5”）。更具体地，公开了通过点突变TRL5激动剂鞭毛蛋白的一些氨基酸制备的鞭毛蛋白突变体，以增强鞭毛蛋白的TRL刺激活性。

5.

发明授权
Preparation of flagellin vaccine adjuvant-based vaccine to induce production of antibody recognizing conformation of antigens, and application thereof 有权

公开(公告)号：US11771753B2

公开(公告)日：2023-10-03

申请号：US17116104

申请日：2020-12-09

申请人： Joon Haeng Rhee , Shee Eun Lee , Kwangjoon Jeong , Sang Chul Park , Wenzhi Tan

发明人： Joon Haeng Rhee , Shee Eun Lee , Kwangjoon Jeong , Sang Chul Park , Wenzhi Tan

IPC分类号： A61K39/02 , C07K14/47 , A61K39/00 , A61K35/68 , A61P25/28 , A61K9/00 , A61K39/12 , A61P31/18

CPC分类号： A61K39/107 , A61K9/0019 , A61K35/68 , A61K39/00 , A61K39/02 , A61K39/12 , A61P25/28 , A61P31/18 , C07K14/47 , A61K2039/51 , A61K2039/6075

摘要： The present invention provides a vaccine composition for use in neurodegenerative diseases and an infectious virus vaccine composition for inducing an antibody recognizing the conformation of antigens. The vaccine composition of the present invention induces the production of an antibody recognizing the conformation of antigens. The antibody recognizing the conformation of antigens has high specificity for an antigen, and thus can be useful for ameliorating, preventing or treating diseases.

6.

发明授权
Preparation of flagellin vaccine adjuvant-based vaccine to induce production of antibody recognizing conformation of antigens, and application thereof 有权

公开(公告)号：US10953082B2

公开(公告)日：2021-03-23

申请号：US16312510

申请日：2016-11-17

申请人： Joon Haeng Rhee , Shee Eun Lee , Kwangjoon Jeong , Sang Chul Park , Wenzhi Tan

发明人： Joon Haeng Rhee , Shee Eun Lee , Kwangjoon Jeong , Sang Chul Park , Wenzhi Tan

IPC分类号： A61K39/02 , C07K14/47 , A61K39/00 , A61K39/12 , A61P25/28 , A61K9/00 , A61P31/18

摘要： The present invention provides a vaccine composition for use in neurodegenerative diseases and an infectious virus vaccine composition for inducing an antibody recognizing the conformation of antigens. The vaccine composition of the present invention induces the production of an antibody recognizing the conformation of antigens. The antibody recognizing the conformation of antigens has high specificity for an antigen, and thus can be useful for ameliorating, preventing or treating diseases.