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    Benzoimidazole derivatives and pharmaceutical composition comprising the same
    3.
    发明授权
    Benzoimidazole derivatives and pharmaceutical composition comprising the same 有权
    苯并咪唑衍生物和包含其的药物组合物

    公开(公告)号：US09199965B2

    公开(公告)日：2015-12-01

    申请号：US11815009

    申请日：2006-01-27

    申请人： Ji Duck Kim ,  Hong Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    发明人： Ji Duck Kim ,  Hong Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    IPC分类号： C07D401/10 ,  C07D417/14 ,  C07D471/04 ,  C07D403/04 ,  C07D403/14

    CPC分类号： C07D401/10 ,  C07D417/14 ,  C07D471/04

    摘要： Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

    摘要翻译： 本文公开了用作香草素受体-1的拮抗剂的新型苯并咪唑衍生物和包含其的药物组合物。 它们可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸系统疾病 作为哮喘，慢性阻塞性肺病等，烧伤，牛皮癣，瘙痒，呕吐，对皮肤，眼睛和粘膜的刺激​​，胃十二指肠溃疡，炎症性肠病和炎性疾病。

    Biaryl benzolmidazole derivatives and pharmaceutical composition comprising the same
    4.
    发明授权
    Biaryl benzolmidazole derivatives and pharmaceutical composition comprising the same 有权
    双芳基苯并咪唑衍生物及其组合物

    公开(公告)号：US08436022B2

    公开(公告)日：2013-05-07

    申请号：US12373193

    申请日：2007-07-11

    申请人： Ji Duck Kim ,  Hong-Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    发明人： Ji Duck Kim ,  Hong-Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    IPC分类号： A61K31/4439 ,  C07D401/04

    CPC分类号： C07D401/10 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

    摘要： Disclosed are biaryl benzoimidazo derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

    摘要翻译： 公开了联芳基苯并咪唑衍生物。 它们对HEK细胞中的钙流入具有抑制作用，从而对香草素受体具有强大的拮抗作用，并具有镇痛作用，因此可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛 ，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经系统疾病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸障碍如咳嗽，哮喘和慢性阻塞性肺病，灼烧，牛皮癣，瘙痒，呕吐， 刺激皮肤，眼睛和粘膜，胃十二指肠溃疡，炎性肠道疾病和炎性疾病。

    Novel Biaryl Benzolmidazole Derivatives and Pharmaceutical Composition Comprising The Same
    7.
    发明申请
    Novel Biaryl Benzolmidazole Derivatives and Pharmaceutical Composition Comprising The Same 有权
    新型双芳基苯并咪唑衍生物和药物组合物

    公开(公告)号：US20090209540A1

    公开(公告)日：2009-08-20

    申请号：US12373193

    申请日：2007-07-11

    申请人： Ji Duck Kim ,  Hong-Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    发明人： Ji Duck Kim ,  Hong-Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    IPC分类号： A61K31/5377 ,  C07D413/14 ,  C07D401/14 ,  A61K31/496 ,  C07D401/02 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/437 ,  C07D471/04 ,  A61P29/00 ,  A61P25/06 ,  A61P11/06 ,  A61P17/06 ,  A61P11/00

    CPC分类号： C07D401/10 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

    摘要： Disclosed are biaryl benzoimidazole derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

    摘要翻译： 公开了联芳基苯并咪唑衍生物。 它们对HEK细胞中的钙流入具有抑制作用，从而对香草素受体具有强大的拮抗作用，并具有镇痛作用，因此可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛 ，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经系统疾病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸障碍如咳嗽，哮喘和慢性阻塞性肺病，灼烧，牛皮癣，瘙痒，呕吐， 刺激皮肤，眼睛和粘膜，胃十二指肠溃疡，炎性肠道疾病和炎性疾病。