公开(公告)号：US20180311345A1

公开(公告)日：2018-11-01

申请号：US15771835

申请日：2016-10-28

申请人： Jordan POBER ,  Daniel JANE-WIT ,  Lingfeng QIN ,  Yi WANG ,  Alexion Pharmaceuticals, Inc. ,  Yale University

发明人： Jordan Pober ,  Daniel Jane-Wit ,  Lingfeng Qin ,  Yi Wang

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P37/06 ,  C07K16/40 ,  A61P9/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/76

摘要： The disclosure provides a method of reducing the likelihood of forming a T cell-mediated allograft vasculopathy lesion in a mammalian transplant recipient comprising transplanting an allograft from a donor to a recipient and administering a therapeutically effective amount of an anti-C5 antibody, or antigen-binding fragment thereof, to the recipient, wherein the anti-C5 antibody, or antigen-binding fragment thereof reduces the likelihood of forming an allograft vasculopathy lesion in the allograft, compared to the absence of treatment with an anti-C5 antibody, or antigen-binding fragment thereof.

公开(公告)号：US20240024470A1

公开(公告)日：2024-01-25

申请号：US18198600

申请日：2023-05-17

申请人： Alexion Pharmaceuticals, Inc. ,  Yale University

发明人： Jordan S. Pober ,  Daniel Jane-Wit ,  Lingfeng Qin ,  Yi Wang

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P9/00 ,  A61P37/06 ,  C07K16/28 ,  C07K16/40

CPC分类号： A61K39/395 ,  C07K16/18 ,  A61P9/00 ,  A61P37/06 ,  C07K16/2839 ,  C07K16/40 ,  A61K2039/505

摘要： The disclosure provides a method of reducing the likelihood of forming a T cell-mediated allograft vasculopathy lesion in a mammalian transplant recipient comprising transplanting an allograft from a donor to a recipient and administering a therapeutically effective amount of an anti-C5 antibody, or antigen-binding fragment thereof, to the recipient, wherein the anti-C5 antibody, or antigen-binding fragment thereof reduces the likelihood of forming an allograft vasculopathy lesion in the allograft, compared to the absence of treatment with an anti-C5 antibody, or antigen-binding fragment thereof.

公开(公告)号：US20230036340A1

公开(公告)日：2023-02-02

申请号：US17781478

申请日：2020-12-04

申请人： YALE UNIVERSITY

发明人： Yibing Qyang ,  Laura Niklason ,  Jiesi Luo ,  Lingfeng Qin ,  Liqiong Gui ,  Matthew Ellis

IPC分类号： A61L27/38 ,  A61K35/44 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  C12N5/071

摘要： The present invention provides a tissue-engineering vascular graft (TEVG) comprising a biodegradable scaffold, and a plurality of stem cell-derived vascular smooth muscle cells (VSMCs), wherein the plurality of stem cell-derived VSMCs are seeded on the biodegradable synthetic polymer scaffold and are cultured under mechanical and biochemical stimulation.