-
公开(公告)号：US20120112055A1
公开(公告)日：2012-05-10
申请号：US13253312
申请日：2011-10-05
CPC分类号： H01J49/0031 , G01N33/15 , G06F19/703 , H01J49/004 , H01J49/26 , Y10T436/24
摘要： A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound.
摘要翻译： 公开了一种搜索潜在未知的药物化合物代谢物的方法。 药物化合物的精确质量通常是已知的，并且可以以整数标称质量或质荷比组分和十进制质量或质荷比组分的形式提供。 基于具有基本上非常相似于母体药物化合物的十进制质量或质荷比的十进制质量或质荷比成分来搜索可能的代谢物。
-
公开(公告)号：US20110095176A1
公开(公告)日：2011-04-28
申请号：US11571338
申请日：2005-07-01
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , G01N33/15 , G06F19/703 , H01J49/004 , H01J49/26 , Y10T436/24
摘要： A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound.
摘要翻译： 公开了一种搜索潜在未知的药物化合物代谢物的方法。 药物化合物的精确质量通常是已知的，并且可以以整数标称质量或质荷比组分和十进制质量或质荷比组分的形式提供。 基于具有基本上非常相似于母体药物化合物的十进制质量或质荷比的十进制质量或质荷比成分来搜索可能的代谢物。
-
公开(公告)号：US08063357B2
公开(公告)日：2011-11-22
申请号：US11571338
申请日：2005-07-01
IPC分类号： G01N24/00
CPC分类号： H01J49/0031 , G01N33/15 , G06F19/703 , H01J49/004 , H01J49/26 , Y10T436/24
摘要： A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound.
摘要翻译： 公开了一种搜索潜在未知的药物化合物代谢物的方法。 药物化合物的精确质量通常是已知的，并且可以以整数标称质量或质荷比组分和十进制质量或质荷比组分的形式提供。 基于具有基本上非常相似于母体药物化合物的十进制质量或质荷比的十进制质量或质荷比成分来搜索可能的代谢物。
-
公开(公告)号：US08841606B2
公开(公告)日：2014-09-23
申请号：US13253312
申请日：2011-10-05
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , G01N33/15 , G06F19/703 , H01J49/004 , H01J49/26 , Y10T436/24
摘要： A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound.
摘要翻译： 公开了一种搜索潜在未知的药物化合物代谢物的方法。 药物化合物的精确质量通常是已知的，并且可以以整数标称质量或质荷比组分和十进制质量或质荷比组分的形式提供。 基于具有基本上非常相似于母体药物化合物的十进制质量或质荷比的十进制质量或质荷比成分来搜索可能的代谢物。
-
5.发明申请METHODS OF TREATING DIABETES BY ADMINISTERING A GLUCAGON RECEPTOR ANTAGONIST IN COMBINATION WITH A CHOLESTEROL ABSORPTION INHIBITOR 审中-公开通过使用GLUCAGON受体拮抗剂与胆固醇吸收抑制剂联合治疗糖尿病的方法公开(公告)号：US20150320724A1
公开(公告)日：2015-11-12
申请号：US14649651
申请日：2013-12-08
申请人： Hong-Ping GUAN , Jose M. CASTRO-PEREZ , Harry R. DAVIS , Samuel S. ENGEL , Douglas G. JOHNS , Songnian LIN , Steven F. PREVIS , Thomas P. RODDY , Liangsu WANG , Sheng-Ping WANG , Yusheng XIONG , MERCK SHARP & DOHME CORP.
发明人： Hong-Ping Guan , Jose M. Castro-Perez , Harry R. Davis , Samuel E. Engel , Douglas G. Johns , Songnian Lin , Stephen F. Previs , Thomas P. Roddy , Liangsu Wang , Sheng-Ping Wang , Yusheng Xiong
IPC分类号： A61K31/4184 , A61K31/194 , A61K31/403 , A61K9/24 , A61K31/397 , A61K31/415
CPC分类号： A61K31/397 , A61K9/209 , A61K31/194 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/435 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： Use of a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor for the treatment of diabetes and related conditions is disclosed.
摘要翻译： 公开了将胰高血糖素受体拮抗剂与胆固醇吸收抑制剂组合用于治疗糖尿病和相关病症的用途。
-
公开(公告)号：US08237106B2
公开(公告)日：2012-08-07
申请号：US12299996
申请日：2007-05-10
IPC分类号： B01D59/44
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/004 , H01J49/0045
摘要： A mass spectrometer comprising a collision, fragmentation or reaction cell (4) is disclosed. The collision, fragmentation or reaction cell (4) is repeatedly switched back and forth between a high fragmentation mode of operation and a low fragmentation mode of operation. Mass spectral data sets are obtained in both modes of operation. A decimal mass filter is applied to one or both sets of data. In particular, fragment ions or metabolites related to a parent or precursor ion of interest are identified on the basis of having a decimal mass which is similar to that of the parent or precursor ion of interest.
摘要翻译： 公开了一种包含碰撞，碎裂或反应池（4）的质谱仪。 碰撞，破碎或反应池（4）在高碎裂操作模式和低碎裂操作模式之间来回重复切换。 在两种操作模式下获得质谱数据集。 十进制质量过滤器应用于一组或两组数据。 特别地，与目标亲本或前体离子相关的片段离子或代谢物基于具有与感兴趣的亲本或前体离子的十进制质量相似的十进制质量来鉴定。
-
公开(公告)号：US20090302210A1
公开(公告)日：2009-12-10
申请号：US12299996
申请日：2007-05-10
申请人： Jose M. Castro-Perez , Jane Kirby , John Shockcor
发明人： Jose M. Castro-Perez , Jane Kirby , John Shockcor
IPC分类号： H01J49/26
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/004 , H01J49/0045
摘要： A mass spectrometer comprising a collision, fragmentation or reaction cell (4) is disclosed. The collision, fragmentation or reaction cell (4) is repeatedly switched back and forth between a high fragmentation mode of operation and a low fragmentation mode of operation. Mass spectral data sets are obtained in both modes of operation. A decimal mass filter is applied to one or both sets of data. In particular, fragment ions or metabolites related to a parent or precursor ion of interest are identified on the basis of having a decimal mass which is similar to that of the parent or precursor ion of interest.
摘要翻译： 公开了一种包含碰撞，碎裂或反应池（4）的质谱仪。 碰撞，破碎或反应池（4）在高碎裂操作模式和低碎裂操作模式之间来回重复切换。 在两种操作模式下获得质谱数据集。 十进制质量过滤器应用于一组或两组数据。 特别地，与目标亲本或前体离子相关的片段离子或代谢物基于具有与感兴趣的亲本或前体离子的十进制质量相似的十进制质量来鉴定。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.023 秒)
