公开(公告)号：US20110286916A1

公开(公告)日：2011-11-24

申请号：US13130441

申请日：2009-11-16

申请人： Jose Miguel Aste-Amezaga ,  Ningyan Zhang ,  Fubao Wang ,  Andrew Bett ,  Anna Demartis ,  Maurizio Nuzzo ,  Paolo Monaci ,  Stephen Blacklow ,  Jon Aster

发明人： Jose Miguel Aste-Amezaga ,  Ningyan Zhang ,  Fubao Wang ,  Andrew Bett ,  Anna Demartis ,  Maurizio Nuzzo ,  Paolo Monaci ,  Stephen Blacklow ,  Jon Aster

IPC分类号： A61K39/395 ,  C12N1/20 ,  A61P35/00 ,  A61K49/00 ,  A61K51/10 ,  C12N9/96 ,  C07K16/28 ,  G01N33/53

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  G01N33/57415

摘要： The present invention relates to mammalian antibodies, preferably fully human monoclonal antibodies and antigen-binding portions thereof that specifically bind to a cell surface receptor, wherein the receptor protein is a Notch1 receptor protein. Some of the disclosed antibodies bind Notch1 to the exclusion of other members of the Notch receptor family, while other antibodies bind Notch 1 and Notch3. Nucleic acid molecules encoding the Notch antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1 or Notch3 including aberrant activation of each of these receptors.

摘要翻译： 本发明涉及特异性结合细胞表面受体的哺乳动物抗体，优选完全人单克隆抗体及其抗原结合部分，其中受体蛋白是Notch1受体蛋白。 一些所公开的抗体结合Notch1排除Notch受体家族的其他成员，而其他抗体结合Notch1和Notch3。 还公开了编码Notch抗体的核酸分子及其使用方法。 还包括包含这些抗体的药物组合物和使用抗体及其组合物用于治疗和诊断与Notch1或Notch3表达相关的病理性过度增殖性致癌性疾病的方法，包括这些受体中的每一种的异常活化。

公开(公告)号：US20130115227A1

公开(公告)日：2013-05-09

申请号：US13809475

申请日：2011-07-13

申请人： Renee C. Gaspar ,  Paul J. Shughrue ,  Fubao Wang ,  Weirong Wang ,  Ningyan Zhang ,  Wei-Qin Zhao ,  Min Xu ,  Alexander McCampbell

发明人： Renee C. Gaspar ,  Paul J. Shughrue ,  Fubao Wang ,  Weirong Wang ,  Ningyan Zhang ,  Wei-Qin Zhao ,  Min Xu ,  Alexander McCampbell

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94

摘要： Disclosed are antibodies that bind amyloid beta-derived diffusible ligands, also known as ADDLs. The antibodies are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.

摘要翻译： 公开了结合淀粉样蛋白β-衍生的扩散配体（也称为ADDL）的抗体。 抗体对ADDL是有选择性的，可以渗透大脑，并且可用于检测ADDLs和诊断阿尔茨海默氏病的方法。 抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与ADDL相关的疾病的方法中是有用的。

公开(公告)号：US20120195831A1

公开(公告)日：2012-08-02

申请号：US13500724

申请日：2010-10-07

申请人： Ningyan Zhang ,  Hans Huber

发明人： Ningyan Zhang ,  Hans Huber

IPC分类号： A61K39/395 ,  C07K16/46 ,  G01N33/574 ,  C07K17/02 ,  A61P35/00 ,  A61K51/10 ,  A61K49/16 ,  A61K49/22 ,  A61K49/04 ,  C07K16/28 ,  C12N9/96

CPC分类号： G01N33/57492 ,  C07K16/32 ,  C07K2317/515 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N2333/485 ,  G01N2333/71 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56

摘要： The present invention relates to Her3 specific antibodies, preferably fully human or humanized antibodies and antigen-binding portions thereof. Nucleic acid molecules encoding the Her3 antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with aberrant expression of Her3 or Her2 including aberrant activation of each of these receptors.

摘要翻译： 本发明涉及Her3特异性抗体，优选完全人或人源化抗体及其抗原结合部分。 还公开了编码Her3抗体的核酸分子及其使用方法。 还包括包含这些抗体的药物组合物和使用抗体及其组合物用于治疗和诊断与Her3或Her2的异常表达相关的病理性过度增殖性致癌性疾病的方法，包括这些受体中的每一种的异常活化。