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公开(公告)号：US5711761A
公开(公告)日：1998-01-27
申请号：US394075
申请日：1995-02-24
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0448 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
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公开(公告)号：US4744787A
公开(公告)日：1988-05-17
申请号：US665698
申请日：1984-10-29
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/0444
摘要： Improved iontophoresis drug delivery apparatus or device wherein one or more electrochemically active components are employed or "sacrificed" so as to minimize the hydrolysis of water during drug delivery. Efficiency of drug delivery is increased and pH changes in the device or adjacent the patient's skin are minimized.
摘要翻译： 改进的离子电渗药物递送装置或装置，其中使用一种或多种电化学活性成分或“牺牲”，以使药物递送期间水的水解最小化。 药物递送的效率增加，并且装置中或患者皮肤附近的pH变化最小化。
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公开(公告)号：US5573503A
公开(公告)日：1996-11-12
申请号：US55394
申请日：1993-04-30
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0448 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
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公开(公告)号：US4747819A
公开(公告)日：1988-05-31
申请号：US665699
申请日：1984-10-29
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/0444
摘要： Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
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公开(公告)号：US5415628A
公开(公告)日：1995-05-16
申请号：US101803
申请日：1993-08-02
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0448 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
摘要翻译： 描述了改进的离子电泳药物递送方法。 通过有选择具有特定特征的药物，离子电渗疗法装置，组分或二者均允许药物递送的效率增加。
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公开(公告)号：US5395310A
公开(公告)日：1995-03-07
申请号：US631753
申请日：1990-12-21
CPC分类号： A61N1/0444 , A61N1/0448
摘要： An improved iontophoresis electrode employing a current distributing member and a drug reservoir containing an ionic drug. The drug reservoir is applied to the skin of a patient, and includes a charge selective ion permeable membrane adapted to contact the skin, through which the ionic drug is delivered.
摘要翻译： 使用电流分布构件的改进的离子电渗电极和含有离子药物的药物储存器。 药物储存器被施加到患者的皮肤，并且包括适于接触皮肤的电荷选择性离子渗透膜，离子药物通过该皮肤递送。
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公开(公告)号：US5135477A
公开(公告)日：1992-08-04
申请号：US154566
申请日：1988-02-10
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0448 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
摘要翻译： 描述了改进的离子电泳药物递送方法。 通过有选择具有特定特征的药物，离子电渗疗法装置，组分或二者均允许药物递送的效率增加。
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8.发明申请Method and Device for Transdermal Electrotransport Delivery of Fentanyl and Sufentanil 审中-公开芬太尼和舒芬太尼透皮电传递方法和装置公开(公告)号：US20090264855A1
公开(公告)日：2009-10-22
申请号：US12194984
申请日：2008-08-20
申请人： Joseph B. Phipps
发明人： Joseph B. Phipps
IPC分类号： A61N1/30
CPC分类号： A61N1/0448
摘要： The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (eg, fentanyl hydrochloride) dispersed in a hydrogel formulation for use in an electrotransport device (10). In accordance with one aspect of the invention, the concentration of fentanyl/sufentanil in the donor reservoir (26) solution is above a predetermined minimum concentration, whereby the transdermal electrotransport flux of fentanyl/sufentanil is maintained independent of the concentration of fentanyl/sufentanil in solution. In accordance with a second aspect of the present invention, the donor reservoir (26) of the electrotransport delivery device (10) is comprised of silver and the donor reservoir (26) contains a predetermined “excess” loading of fentanyl/sufentanil halide to prevent silver ion migration with attendant skin discoloration. In accordance with a third aspect of the present invention, a transdermal electrotransport delivered dose of fentanyl/sufentanil is provided which is sufficient to induce analgesia in (eg, adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.
摘要翻译： 本发明提供了一种用于镇痛药物，即芬太尼和舒芬太尼的改进的电转运药物递送系统。 芬太尼/舒芬太尼作为分散在用于电转运装置（10）的水凝胶制剂中的水溶性盐（例如盐酸芬太尼）提供。 根据本发明的一个方面，供体储存器（26）溶液中芬太尼/舒芬太尼的浓度高于预定的最小浓度，由此芬太尼/舒芬太尼的透皮电转运通量与芬太尼/舒芬太尼的浓度无关 解。 根据本发明的第二方面，电运输输送装置（10）的供体储存器（26）由银组成，供体储存器（26）含有预定的“过量”负荷的芬太尼/舒芬太尼卤化物以防止 银离子迁移伴随皮肤变色。 根据本发明的第三方面，提供透皮电转运量的芬太尼/舒芬太尼，其足以在与主要外科手术相关的中度至重度疼痛的（例如成人）人类患者中诱发镇痛。
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9.发明授权Reservoir and a series of related reservoirs for use in an electrotransport drug delivery device and devices comprised thereof 有权水库和一系列用于电输送药物输送装置的相关储存器及其组成的装置公开(公告)号：US06975902B2
公开(公告)日：2005-12-13
申请号：US10609211
申请日：2003-06-27
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： A reservoir and a family of reservoirs are provided which are designed to be used with a single controller to provide a wide range of therapeutic drug delivering regimens while maintaining many of the same reservoir configurations and drug formulations. A method of making a reservoir and a family of reservoirs and incorporating them into an electrotransport system is disclosed.
摘要翻译： 提供了储存器和一系列储存器，其设计成与单个控制器一起使用以提供广泛的治疗药物递送方案，同时保持许多相同的储存器构型和药物制剂。 公开了一种制造储存器和一系列储存器并将其并入到电输送系统中的方法。
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公开(公告)号：US06881208B1
公开(公告)日：2005-04-19
申请号：US08465492
申请日：1995-06-05
IPC分类号： A61K9/00 , A61K31/4468 , A61K31/4535 , A61N1/30 , A61P25/04 , A61M5/32
CPC分类号： A61N1/0436 , A61N1/0448
摘要： The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (eg, fentanyl hydrochloride) dispersed in a hydrogel formulation for use in an electrotransport device (10). In accordance with one aspect of the invention, the concentration of fentanyl/sufentanil in the donor reservoir (26) solution is above a predetermined minimum concentration, whereby the transdermal electrotransport flux of fentanyl/sufentanil is maintained independent of the concentration of fentanyl/sufentanil in solution. In accordance with a second aspect of the present invention, the donor reservoir (26) of the electrotransport delivery device (10) is comprised of silver and the donor reservoir (26) contains a predetermined “excess” loading of fentanyl/sufentanil halide to prevent silver ion migration with attendant skin discoloration. In accordance with a third aspect of the present invention, a transdermal electrotransport delivered dose of fentanyl/sufentanil is provided which is sufficient to induce analgesia in (eg, adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.
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