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公开(公告)号：US20110016542A1
公开(公告)日：2011-01-20
申请号：US12842839
申请日：2010-07-23
申请人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
发明人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
IPC分类号： G01N33/00 , A01K67/027 , C12N5/071
CPC分类号： A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2227/10 , A01K2267/03 , C12N9/22 , C12N2800/80
摘要： The present invention provides a genetically modified canine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the canine genome.
摘要翻译： 本发明提供了包含至少一个编辑的染色体序列的遗传修饰的犬或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对犬基因组中特定染色体序列的锌指核酸酶。
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公开(公告)号：US20110023159A1
公开(公告)日：2011-01-27
申请号：US12842204
申请日：2010-07-23
申请人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
发明人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
IPC分类号： A01K67/027 , C12N5/10
CPC分类号： C12N9/22 , A01K67/0275 , A01K2227/103 , C12N2800/80
摘要： The present invention provides a genetically modified ovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the ovine genome.
摘要翻译： 本发明提供了包含至少一个经编辑的染色体序列的遗传修饰的羊或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对羊基因组中特定染色体序列的锌指核酸酶。
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公开(公告)号：US20110023154A1
公开(公告)日：2011-01-27
申请号：US12842269
申请日：2010-07-23
申请人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
发明人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
CPC分类号： A01K67/0335 , A01K2227/703 , A01K2267/02 , C12N9/22 , C12N15/8509 , C12N2800/80
摘要： The present invention provides a genetically modified silkworm or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the silkworm genome.
摘要翻译： 本发明提供了包含至少一个编辑的染色体序列的遗传修饰的蚕或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对家蚕基因组中特定染色体序列的锌指核酸酶。
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公开(公告)号：US20110016546A1
公开(公告)日：2011-01-20
申请号：US12842893
申请日：2010-07-23
申请人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
发明人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
IPC分类号： A01K67/027 , C12N5/10
CPC分类号： C12N9/22 , A01K67/0275 , A01K2207/15 , A01K2227/108 , A01K2267/02 , A01K2267/03 , C12N2800/80
摘要： The present invention provides a genetically modified porcine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the porcine genome.
摘要翻译： 本发明提供了包含至少一个编辑的染色体序列的遗传修饰的猪或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对猪基因组中特定染色体序列的锌指核酸酶。
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公开(公告)号：US20110023140A1
公开(公告)日：2011-01-27
申请号：US12842208
申请日：2010-07-23
申请人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
发明人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
IPC分类号： A01K67/027 , C12N5/10 , G01N33/00
CPC分类号： A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2227/107 , A01K2267/03 , C12N9/22 , C12N15/8509 , C12N2800/80
摘要： The present invention provides a genetically modified rabbit or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the rabbit genome.
摘要翻译： 本发明提供了包含至少一个编辑的染色体序列的遗传修饰的兔或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对兔基因组中特定染色体序列的锌指核酸酶。
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公开(公告)号：US20110023158A1
公开(公告)日：2011-01-27
申请号：US12842188
申请日：2010-07-23
申请人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
发明人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
IPC分类号： A01K67/027 , C12N5/071
CPC分类号： A01K67/0276 , A01K2227/101 , C12N9/22 , C12N2800/80
摘要： The present invention provides a genetically modified bovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the bovine genome.
摘要翻译： 本发明提供了包含至少一个经编辑的染色体序列的遗传修饰的牛或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对牛基因组中特定染色体序列的锌指核酸酶。
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公开(公告)号：US20110023157A1
公开(公告)日：2011-01-27
申请号：US12842886
申请日：2010-07-23
申请人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
发明人： Joseph Bedell , Brian Buntaine , Xiaoxia Cui
IPC分类号： A01K67/027 , C12N5/071 , C12N5/10
CPC分类号： A01K67/0276 , A01K67/0278 , A01K2217/05 , A01K2227/10 , C12N9/22 , C12N2800/80
摘要： The present invention provides a genetically modified equine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the equine genome.
摘要翻译： 本发明提供了包含至少一个经编辑的染色体序列的遗传修饰的马或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对马基因组中特定染色体序列的锌指核酸酶。
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公开(公告)号：US20110023156A1
公开(公告)日：2011-01-27
申请号：US12842219
申请日：2010-07-23
申请人： Joseph Bedell , Gregory Davis , Shondra Miller , Brian Buntaine , Xiaoxia Cui
发明人： Joseph Bedell , Gregory Davis , Shondra Miller , Brian Buntaine , Xiaoxia Cui
IPC分类号： A01K67/027 , C12N5/071 , C12N5/10 , C12N9/16 , C07H21/04
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2227/10 , A01K2267/02 , C12N9/22 , C12N2800/80
摘要： The present invention provides a genetically modified feline or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the feline genome.
摘要翻译： 本发明提供了包含至少一个编辑的染色体序列的遗传修饰的猫科动物或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对猫基因组中特定染色体序列的锌指核酸酶。
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公开(公告)号：US20120100541A1
公开(公告)日：2012-04-26
申请号：US13280092
申请日：2011-10-24
申请人： Jared Ordway , Jeffrey A. Jeddeloh , Joseph Bedell
发明人： Jared Ordway , Jeffrey A. Jeddeloh , Joseph Bedell
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , Y10T436/143333
摘要： The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use in detecting and diagnosing cancer.
摘要翻译： 本发明提供了在具有癌症的正常个体和个体的样品中差异甲基化的DNA生物标志物序列。 本发明还提供鉴定差异甲基化DNA生物标志物序列及其在检测和诊断癌症中的用途的方法。
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公开(公告)号：US08067168B2
公开(公告)日：2011-11-29
申请号：US11809355
申请日：2007-05-30
申请人： Jared Ordway , Jeffrey A. Jeddeloh , Joseph Bedell
发明人： Jared Ordway , Jeffrey A. Jeddeloh , Joseph Bedell
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , Y10T436/143333
摘要： The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use in detecting and diagnosing cancer.
摘要翻译： 本发明提供了在具有癌症的正常个体和个体的样品中差异甲基化的DNA生物标志物序列。 本发明还提供鉴定差异甲基化DNA生物标志物序列及其在检测和诊断癌症中的用途的方法。
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