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1.发明授权公开(公告)号：US06501549B1
公开(公告)日：2002-12-31
申请号：US09077694
申请日：1998-12-03
IPC分类号： G01B1100
CPC分类号： G01N21/763 , G01N21/6456 , G01N21/76
摘要： A method and associated apparatus for measuring chemical concentration in a liquid sample based on spatial separation and resolution of light is disclosed. The method is preferably applied to sensitive, quantitative, luminescence-based biosensors which reads the analyte concentration via spatial distribution of the emitted light. The detection of light is used to assess the spatial position, rather than the intensity or wavelength, of emitted light. A bioluminescent or chemiluminescent reaction requiring, for example, ATP, NADPH or NADH as a specific, and sensitive co-factor is used. ATP or NADH concentration is modulated, “tuned,” and/or regulated via, for example, an enzyme which consumes (“consumase”) ATP, NADPH, or NADH, thereby producing a spatial distribution of ATP or NADH and a spatial distribution in the emitted light. By appropriate control of the consumase or “synthase” activity and kinetics, a sensitive, specific, and easily readable luminescent pattern is produced, permitting detection.
摘要翻译： 公开了一种基于空间分离和光分辨率来测量液体样品中化学浓度的方法和相关装置。 该方法优选地应用于通过发射光的空间分布读取分析物浓度的灵敏的，定量的，基于发光的生物传感器。 光的检测用于评估发射光的空间位置，而不是强度或波长。 使用需要例如ATP，NADPH或NADH作为特异性和敏感辅因子的生物发光或化学发光反应。 ATP或NADH浓度通过例如消耗（“消耗”）ATP，NADPH或NADH的酶“调节”和/或调节，由此产生ATP或NADH的空间分布和空间分布 发出的光。 通过适当控制消耗或“合成酶”活性和动力学，产生敏感，特异且容易读取的发光图案，允许检测。
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2.发明授权Process for treating polymer surfaces to reduce their friction resistance characteristics when in contact with non-polar liquid, and resulting products 失效用于处理聚合物表面以在与非极性液体接触时产生的摩擦阻力特性以及所得产物的方法降低
公开(公告)号：US4508606A
公开(公告)日：1985-04-02
申请号：US495209
申请日：1983-05-16
摘要： Surfaces of hydrophobic polymers are treated to reduce their friction resistance characteristics when in contact with an aqueous environment by exposing the surfaces to an oxidation treatment, preferably by use of radio frequency glow discharge. This oxidation is followed by exposure to atmospheric air, until there is a substantial reduction in the air-water contact angle of the surfaces. The reduced friction resistance characteristics are important in aqueous applications where there is movement between the surfaces of two polymeric materials, such as in double slideable catheters and similar medical products. This process also provides lower coefficients of friction for general polymeric products in contact with water and aqueous solutions.
摘要翻译： 处理疏水性聚合物的表面以通过将表面暴露于氧化处理（优选通过使用射频辉光放电）与水性环境接触来降低其摩擦阻力特性。 这种氧化之后是暴露于大气中，直到表面的空气 - 水接触角显着降低。 降低的摩擦阻力特性在水性应用中是重要的，其中在两个聚合物材料的表面之间存在运动，例如在双滑动导管和类似医疗产品中。 该方法还为与水和水溶液接触的一般聚合物产品提供较低的摩擦系数。
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公开(公告)号：US5324518A
公开(公告)日：1994-06-28
申请号：US860434
申请日：1992-03-30
CPC分类号： A61M39/0208 , A61B5/14532
摘要： An implantable structure for incorporation into the tissues of a body is provided which retains therein fluid substances or biological substances which produce, or cause to be produced, biochemicals deliverable to the body. The implantable structure is configured to provide insertion and removal of substances therefrom as needed. The implantable structure generally comprises a porous outer member configured to encourage ingrowth of vascularized tissue therethrough, and an inner member of selectively permeable material providing interior space for inserting substances therein and which is structured to prevent ingrowth of tissue therethrough. The inner member is capable of providing immunoisolation to the substances therein as required.
摘要翻译： 提供用于结合到身体的组织中的可植入结构，其保留产生或导致产生生物化学物质输送到身体的流体物质或生物物质。 可植入结构被配置成根据需要提供物质的插入和移除。 可植入结构通常包括构造成促进血管化组织向内生长的多孔外部构件，以及选择性渗透材料的内部构件，其提供用于在其中插入物质的内部空间，其被构造成防止组织通过其向内生长。 内部构件能够根据需要向其中的物质提供免疫隔离。
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公开(公告)号：US06293929B1
公开(公告)日：2001-09-25
申请号：US08925866
申请日：1997-09-09
IPC分类号： A61M3500
CPC分类号： A61M3/0262 , A61B90/05 , A61M3/0287
摘要： A wound irrigation apparatus comprising a fillable fluid delivery member, a fluid channel, and a splash shield for use in wound irrigation is disclosed. The splash shield is a three-dimensional shield positionable about a wound to protect medical personnel from the back splash resulting from wound irrigation and is at least partially flexible and compliant for shaping the shield to fit the unique shape or dimension of a wound. The flexible peripheral edge of the splash shield also prevents damage to the wound if the shield should come in contact with the wound. The shield may also be structured to provide selective angular adjustment of fluid delivery to the wound. The shield of the present invention generally comprises a shield member and a hub positioned through the surface of the shield member to direct fluid to a wound. The shield member may be structured to provide selective angular positioning of the hub to selectively direct fluid to the wound site. The fluid channel may be variable in length, internal diameter and bore shape to selectively determine the pressure at which fluid is delivered to the wound site and to selectively determine the spray pattern. The wound irrigation apparatus may also include an ergonomically designed handle attachable to the fillable fluid delivery member for facilitating filling and evacuation of the fluid delivery member.
摘要翻译： 公开了一种伤口灌溉装置，包括可填充流体输送构件，流体通道和用于伤口冲洗的防溅罩。 防溅罩是围绕伤口定位的三维屏蔽物，用于保护医务人员免受伤口冲洗引起的背部飞溅，并且至少部分地具有灵活性和柔顺性，以使护罩成形以适应伤口的独特形状或尺寸。 如果防护罩与伤口接触，防溅罩的柔性外围边缘也能防止损伤伤口。 护罩还可以构造成提供对伤口的流体输送的选择性角度调整。 本发明的护罩通常包括屏蔽构件和定位成穿过屏蔽构件的表面以将流体引导到伤口的毂。 屏蔽构件可以被构造成提供毂的选择性角度定位以选择性地将流体引导到伤口部位。 流体通道的长度，内径和孔形状可以是可变的，以选择性地确定流体被输送到伤口部位的压力并选择性地确定喷射模式。 伤口灌洗装置还可以包括可附接到可填充流体输送构件的符合人体工程学设计的手柄，以便于填充和排出流体输送构件。
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公开(公告)号：US4662884A
公开(公告)日：1987-05-05
申请号：US603835
申请日：1984-04-25
CPC分类号： A61F2/04 , A61B17/1128 , A61F2002/30235 , A61F2230/0069
摘要： The present invention is directed to prostheses and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis. In one preferred embodiment, a monosuture is used to hold the nerve ends in close proximity. A tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured nerve within the prosthesis from the rest of the body of the host. Additionally, in one preferred embodiment, nerve grafts may be incorporated into the prosthesis and nerve regeneration promoting substances may be incorporated within the nerve graft to further enhance nerve regeneration. Prostheses and methods for inhibiting the formation of neuromas are also disclosed.
摘要翻译： 本发明涉及用于促进神经再生的假体和方法。 切断的神经的近端和远端紧密接近，并被管状假体包围。 在一个优选实施例中，使用单缝来保持紧邻的神经末端。 在假体和受损的神经之间形成紧密的密封，以将假体中的受伤神经与主体的其余部分分离。 此外，在一个优选实施例中，神经移植物可以并入假体中，并且可以将神经再生促进物质并入神经移植物内以进一步增强神经再生。 还公开了抑制神经瘤形成的假体和方法。
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6.发明授权
公开(公告)号：US5100392A
公开(公告)日：1992-03-31
申请号：US447635
申请日：1989-12-08
CPC分类号： A61M39/0208 , A61B5/14532
摘要： An implantable device for administering drugs or other substances to body tissues of a patient is disclosed. The device is designed to allow controlled ingrowth of connective tissue into the device, and a solution may be pumped or injected into the device where the solution is diffused through the ingrown connective tissue and out into the body.
摘要翻译： 公开了一种用于向患者的身体组织施用药物或其他物质的可植入装置。 该装置被设计成允许结缔组织的受控向内生长进入装置，并且可以将溶液泵入或注入到装置中，其中溶液通过内插的结缔组织扩散并进入体内。
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公开(公告)号：US5209732A
公开(公告)日：1993-05-11
申请号：US664984
申请日：1991-03-04
CPC分类号： A61M5/315 , A61M25/1018 , A61M25/104 , A61M5/484
摘要： A locking syringe selectively operable in either of a freely reciprocating or a restricted, threaded mode. A trigger attached to the plunger includes internal threads on the interior of the barrel of the syringe and external threads located on the plunger on a spine slidable in a longitudinal slot in the plunger. A handle is affixed to the plunger, and a retraction bar is rigidly secured to the spine. The threads on the plunger may be retracted from engagement with the threads on the barrel, thereby placing the syringe in its freely reciprocating mode. The trigger, which is spring biased to engage the external and internal threads, employs a plurality of ramps and channels disposed at approximately the same angle to the longitudinal axes of the plunger and barrel as are the threads. A pawl is pivotally securable on the retraction bar at a position receivable into a pawl receiving aperture on the handle when the receiving bar is in its first position permitting reciprocating movement of the plunger. In this position, the pawl prevents the retraction bar from returning to its second position in which free movement of the plunger is precluded. Alternatively, toward the same end an open, a circumferential clip can be placed on the plunger to restrain sliding of the spine disposed therein, or a plug can be inserted into an aperture in the handle occupied by the retraction bar in its first position.
摘要翻译： 可选择地在自由往复式或受限制的螺纹模式下操作的锁定注射器。 附接到柱塞的触发器包括在注射器的筒体内部的内螺纹和位于柱塞上的柱塞上的外螺纹，该脊柱可在柱塞的纵向槽中滑动。 手柄固定在柱塞上，并且收缩杆刚性地固定到脊柱上。 柱塞上的螺纹可以缩回与筒上的螺纹接合，从而将注射器置于其自由往复运动模式。 弹簧偏置以接合外螺纹和内螺纹的触发器采用多个斜面和通道，其与螺纹一样以与柱塞和圆筒的纵向轴线大致相同的角度设置。 当接收杆处于其允许柱塞往复移动的第一位置时，棘爪可枢转地固定在收缩杆上的可接收到手柄上的棘爪接收孔中的位置。 在该位置，棘爪防止回缩杆返回到其排除柱塞的自由运动的第二位置。 或者，朝向相同的端部是开放的，周向夹可以被放置在柱塞上以限制设置在其中的脊柱的滑动，或者插头可以插入在由缩回杆在其第一位置占据的手柄中的孔中。
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8.发明授权Prostheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas 失效用于促进神经再生和抑制神经瘤形成的假肢和方法
公开(公告)号：US4778467A
公开(公告)日：1988-10-18
申请号：US884088
申请日：1986-07-10
CPC分类号： A61F2/04 , A61B17/1128 , A61F2002/30235 , A61F2230/0069
摘要： The present invention is directed to prosthesis and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis. In one preferred embodiment, a epineurial or endoneurial monosuture is used to hold the nerve ends in close proximity. A tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured nerve within the prosthesis from the rest of the body of the host. Additionally, in one preferred embodiment, nerve grafts may be incorporated into the prosthesis and nerve regeneration promoting substances may be incorporated within the nerve graft to further enhance nerve regeneration. In another preferred embodiment, a prosthesis is coated with a material which is slippery with relation to the surrounding body tissue and the prosthesis is formed of or coated with a material around the inside of the prosthesis which will substantially adhere to the severed nerve ends so as to prevent substantial movement of the severed nerve ends within the prosthesis. In yet another preferred embodiment, such an outside coating around the prosthesis terminates in two longitudinal flaps which serve to form a fluid-tight seal along the tubular prosthesis. In still another preferred embodiment, the ends of the prosthesis overlap and are formed so as to bias against each other in a spiral tube configuration, thereby providing for firm closure of the prosthesis around a variety of sizes of injured nerves. Also disclosed are various devices and methods for inhibiting the formation of neuromas, such as an open-ended tube or a neuroma-inhibition device formed as a cap member having a reservoir formed therein.
摘要翻译： 本发明涉及用于促进神经再生的假体和方法。 切断的神经的近端和远端紧密接近，并被管状假体包围。 在一个优选实施例中，使用神经节或内膜单节使得紧密接近的神经末端。 在假体和受损的神经之间形成紧密的密封，以将假体中的受伤神经与主体的其余部分分离。 此外，在一个优选实施例中，神经移植物可以并入假体中，并且可以将神经再生促进物质并入神经移植物内以进一步增强神经再生。 在另一个优选实施例中，假体用相对于周围身体组织滑动的材料涂覆，并且假体由假体附近的材料形成或涂覆，该材料将基本上粘附到切断的神经末端，以便 以防止假体中切断的神经末梢的实质运动。 在另一个优选实施例中，假体周围的这种外部涂层终止于两个纵向翼片，其用于沿着管状假体形成流体密封的密封。 在另一优选实施例中，假体的端部重叠并形成为以螺旋管构造彼此偏压，从而提供围绕各种尺寸的受伤神经的假体的牢固关闭。 还公开了用于抑制神经瘤形成的各种装置和方法，例如形成为具有在其中形成的储液器的盖构件的开口管或神经阻滞装置。
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