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22 条记录 (耗时 0.031 秒)

    Use of methylnaltrexone and related compounds to treat chronic opioid use side affects
    1.
    发明授权
    Use of methylnaltrexone and related compounds to treat chronic opioid use side affects 有权
    使用甲基纳曲酮及其相关化合物治疗慢性阿片类药物使用方面的影响

    公开(公告)号：US06559158B1

    公开(公告)日：2003-05-06

    申请号：US09669358

    申请日：2000-09-26

    申请人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    发明人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    IPC分类号： A61K31485

    CPC分类号： A61K31/485

    摘要： A method of preventing or treating an opioid-induced side effect in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.

    摘要翻译： 一种在长期摄取阿片样物质的患者中预防或治疗阿片样物质诱导的副作用的方法，所述方法包括以足以防止或治疗患者副作用的量施用去甲吗啡酮的季衍生物， 不足以治疗没有长期服用阿片类药物的相同阿片样物质诱导的副作用的患者。

    Use of methylnaltrexone and related compounds
    3.
    发明授权
    Use of methylnaltrexone and related compounds 有权
    使用甲基纳曲酮及其相关化合物

    公开(公告)号：US06608075B2

    公开(公告)日：2003-08-19

    申请号：US09862169

    申请日：2001-05-21

    申请人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    发明人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    IPC分类号： A61K31485

    CPC分类号： A61K31/485

    摘要： A method for preventing or treating opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.

    摘要翻译： 一种预防或治疗阿片样物质诱导胃肠蠕动变化的方法。 所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物以肠溶包衣形式口服给药 。

    Use of methylnaltrexone and related compounds
    4.
    发明授权
    Use of methylnaltrexone and related compounds 失效
    使用甲基纳曲酮及其相关化合物

    公开(公告)号：US06274591B1

    公开(公告)日：2001-08-14

    申请号：US09120703

    申请日：1998-07-22

    申请人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    发明人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    IPC分类号： A61K31448

    CPC分类号： A61K31/485

    摘要： A method for preventing or treating the opioid induced side effect, inhibition of gastrointestinal motility is disclosed. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.

    摘要翻译： 公开了一种预防或治疗阿片样物质诱导的副作用，抑制胃肠蠕动的方法。 所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物以肠溶包衣形式口服给药 。

    Use of methylnaltrexone and related compounds
    7.
    发明授权
    Use of methylnaltrexone and related compounds 失效
    使用甲基纳曲酮及其相关化合物

    公开(公告)号：US5972954A

    公开(公告)日：1999-10-26

    申请号：US962742

    申请日：1997-11-03

    申请人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    发明人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    IPC分类号： A61K31/485

    CPC分类号： A61K31/485

    摘要： A method for preventing or treating opioid induced side effects including dysphoria, pruritus and urinary retention and non-opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered by the route selected from the group consisting of intravenous, intramuscular, transmucosal, transdermal, and oral administration, preferably administered orally in an enterically coated form.

    摘要翻译： 一种预防或治疗阿片样物质诱发的副作用的方法，包括躁动症，瘙痒和尿潴留以及非阿片样物质诱导的胃肠蠕动变化。 所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物通过选自 静脉内，肌肉内，经粘膜，透皮和口服给药组，优选以肠溶包衣形式口服给药。

    Use of methylnaltrexone and related compounds
    8.
    发明申请
    Use of methylnaltrexone and related compounds 审中-公开
    使用甲基纳曲酮及其相关化合物

    公开(公告)号：US20050048117A1

    公开(公告)日：2005-03-03

    申请号：US10962729

    申请日：2004-10-12

    申请人： Joseph Foss ,  Michael Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    发明人： Joseph Foss ,  Michael Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    IPC分类号： A61K31/485 ,  A61K9/24

    CPC分类号： A61K31/485

    摘要： A composition for preventing or treating the opioid induced side effect, inhibition of gastrointestinal motility is disclosed. The composition comprises methylnaltrexone or another quaternary derivative of noroxymorphone administered to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.

    摘要翻译： 公开了用于预防或治疗阿片样物质诱导的副作用，抑制胃肠蠕动的组合物。 该组合物包含甲基纳曲酮或在给予阿片样物体之前向患者施用的诺莫诺莫司的另一季衍生物，或者在施用阿片样物质引起的副作用开始后，其中甲醛纳曲酮或季衍生物以肠溶包衣形式口服给药 。

    Method for detecting cyanide in cutaneously transpired gas
    9.
    发明授权
    Method for detecting cyanide in cutaneously transpired gas 失效
    在透气气体中检测氰化物的方法

    公开(公告)号：US6126612A

    公开(公告)日：2000-10-03

    申请号：US970160

    申请日：1997-11-13

    申请人： Michael F. Roizen ,  Jonathan Moss ,  Carl Peck

    发明人： Michael F. Roizen ,  Jonathan Moss ,  Carl Peck

    IPC分类号： A61B5/00 ,  A61N5/00 ,  G01N33/84

    CPC分类号： G01N33/84 ,  G01N2800/40

    摘要： A method of detecting cyanide concentration in the cutaneously transpired gas of a patient, allowing for the timely implementation of an appropriate treatment. Where the skin of a patient suffering from cyanide poisoning has been burnt, the present invention provides for a noninvasive means of cyanide treatment. In practice, a material is impregnated with methemoglobin and attached to a patient's skin. A barrier means located between the impregnated material and the patient's skin allows for the transfer of cyanide gas from the patient into the material. However, this barrier means does not allow for the transfer of the methemoglobin from the impregnated material into the patient's skin. The material is monitored for photometric change, and, where a change indicative of cyanide poinsoning is present, appropriate treatment is administered.

    摘要翻译： 检测患者的皮肤蒸发气体中的氰化物浓度的方法，以便及时实施适当的治疗。 在患有氰化物中毒的患者的皮肤已被烧伤的地方，本发明提供了一种非侵入性氰化物处理方法。 实际上，材料用高铁血红蛋白浸渍并附着在患者的皮肤上。 位于浸渍材料和患者皮肤之间的屏障装置允许将氰化物气体从患者转移到材料中。 然而，这种阻挡装置不允许将高铁血红蛋白从浸渍的材料转移到患者的皮肤中。 监测材料的光度变化，并且当存在指示氰化物斑点化的变化时，施用适当的处理。