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公开(公告)号：US6126612A
公开(公告)日：2000-10-03
申请号：US970160
申请日：1997-11-13
申请人： Michael F. Roizen , Jonathan Moss , Carl Peck
发明人： Michael F. Roizen , Jonathan Moss , Carl Peck
CPC分类号： G01N33/84 , G01N2800/40
摘要： A method of detecting cyanide concentration in the cutaneously transpired gas of a patient, allowing for the timely implementation of an appropriate treatment. Where the skin of a patient suffering from cyanide poisoning has been burnt, the present invention provides for a noninvasive means of cyanide treatment. In practice, a material is impregnated with methemoglobin and attached to a patient's skin. A barrier means located between the impregnated material and the patient's skin allows for the transfer of cyanide gas from the patient into the material. However, this barrier means does not allow for the transfer of the methemoglobin from the impregnated material into the patient's skin. The material is monitored for photometric change, and, where a change indicative of cyanide poinsoning is present, appropriate treatment is administered.
摘要翻译： 检测患者的皮肤蒸发气体中的氰化物浓度的方法，以便及时实施适当的治疗。 在患有氰化物中毒的患者的皮肤已被烧伤的地方，本发明提供了一种非侵入性氰化物处理方法。 实际上，材料用高铁血红蛋白浸渍并附着在患者的皮肤上。 位于浸渍材料和患者皮肤之间的屏障装置允许将氰化物气体从患者转移到材料中。 然而，这种阻挡装置不允许将高铁血红蛋白从浸渍的材料转移到患者的皮肤中。 监测材料的光度变化，并且当存在指示氰化物斑点化的变化时，施用适当的处理。
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2.发明授权Use of methylnaltrexone and related compounds to treat chronic opioid use side affects 有权使用甲基纳曲酮及其相关化合物治疗慢性阿片类药物使用方面的影响公开(公告)号：US06559158B1
公开(公告)日：2003-05-06
申请号：US09669358
申请日：2000-09-26
IPC分类号： A61K31485
CPC分类号： A61K31/485
摘要： A method of preventing or treating an opioid-induced side effect in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.
摘要翻译： 一种在长期摄取阿片样物质的患者中预防或治疗阿片样物质诱导的副作用的方法，所述方法包括以足以防止或治疗患者副作用的量施用去甲吗啡酮的季衍生物， 不足以治疗没有长期服用阿片类药物的相同阿片样物质诱导的副作用的患者。
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公开(公告)号：US06608075B2
公开(公告)日：2003-08-19
申请号：US09862169
申请日：2001-05-21
IPC分类号： A61K31485
CPC分类号： A61K31/485
摘要： A method for preventing or treating opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.
摘要翻译： 一种预防或治疗阿片样物质诱导胃肠蠕动变化的方法。 所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物以肠溶包衣形式口服给药 。
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公开(公告)号：US06274591B1
公开(公告)日：2001-08-14
申请号：US09120703
申请日：1998-07-22
IPC分类号： A61K31448
CPC分类号： A61K31/485
摘要： A method for preventing or treating the opioid induced side effect, inhibition of gastrointestinal motility is disclosed. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.
摘要翻译： 公开了一种预防或治疗阿片样物质诱导的副作用，抑制胃肠蠕动的方法。 所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物以肠溶包衣形式口服给药 。
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5.发明申请公开(公告)号：US20120277260A1
公开(公告)日：2012-11-01
申请号：US13533578
申请日：2012-06-26
IPC分类号： A61K31/485 , A61P1/00
CPC分类号： A61K31/485
摘要： A method of preventing or treating constipation in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.
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6.发明申请USE OF METHYLNALTREXONE AND RELATED COMPOUND TO TREAT CONSTIPATION IN CHRONIC OPIOID USERS 审中-公开甲基放射线及其相关化合物在慢性阿片类药物中的使用公开(公告)号：US20100087472A1
公开(公告)日：2010-04-08
申请号：US12495324
申请日：2009-06-30
IPC分类号： A61K31/485 , A61P1/10
CPC分类号： A61K31/485
摘要： A method of preventing or treating constipation in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.
摘要翻译： 一种在慢性服用阿片样物质的患者中预防或治疗便秘的方法，所述方法包括以足以防止或治疗患者副作用的量施用去甲吗啡酮的季衍生物，但是哪种量不足以治疗 具有相同阿片类药物副作用的患者，没有长期服用阿片样物质。
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7.发明申请USE OF METHYLNALTREXONE AND RELATED COMPOUNDS FOR TREATMENT OF GASTROINTESTINAL DYSFUNCTION INDUCED BY ENDOGENOUS OPIOIDS 审中-公开使用甲基内酯和相关化合物治疗由内源性OPIOIDS诱导的胃肠功能异常公开(公告)号：US20090312359A1
公开(公告)日：2009-12-17
申请号：US12333912
申请日：2008-12-12
IPC分类号： A61K31/485
CPC分类号： A61K31/485
摘要： A method of for preventing or treating gastrointestinal dysfunction and constipation caused by endogenous opioids in a patient who has been chronically taking opioids. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone most preferably by parenteral, intramuscular, intravenous or oral route.
摘要翻译： 一种在慢性服用阿片样物质的患者中预防或治疗由内源性阿片样物质引起的胃肠功能障碍和便秘的方法。 所述方法包括最优选通过肠胃外，肌内，静脉内或口服途径施用甲氧基纳曲酮或其它去甲吗啡酮的季衍生物。
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公开(公告)号：US5972954A
公开(公告)日：1999-10-26
申请号：US962742
申请日：1997-11-03
IPC分类号： A61K31/485
CPC分类号： A61K31/485
摘要： A method for preventing or treating opioid induced side effects including dysphoria, pruritus and urinary retention and non-opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered by the route selected from the group consisting of intravenous, intramuscular, transmucosal, transdermal, and oral administration, preferably administered orally in an enterically coated form.
摘要翻译： 一种预防或治疗阿片样物质诱发的副作用的方法，包括躁动症，瘙痒和尿潴留以及非阿片样物质诱导的胃肠蠕动变化。 所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物通过选自 静脉内，肌肉内，经粘膜，透皮和口服给药组，优选以肠溶包衣形式口服给药。
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公开(公告)号：US20150362584A1
公开(公告)日：2015-12-17
申请号：US14760821
申请日：2014-01-07
申请人： Alan JENKINS , Jonathan MOSS
发明人： Alan Jenkins , Jonathan Moss
IPC分类号： G01S7/40
CPC分类号： G01S7/4056 , G01S13/931 , G01S2007/4069
摘要： A self-testing method of a frequency-modulated continuous-wave(FMCW) radar device. A transmission signal having an object detection signal and a self-test signal superimposed on the object detection signal is transmitted. The self-test signal represents at least one virtual target. A reception signal is received. The reception signal is a received version of the transmission signal. Presence of the at least one virtual target in the reception signal is determined. A lack of presence of the virtual target in the reception signal provides an indication of hardware failure of the FMCW radar device.
摘要翻译： 一种频率调制连续波（FMCW）雷达装置的自检方法。 发送具有叠加在物体检测信号上的物体检测信号和自检信号的发送信号。 自检信号表示至少一个虚拟目标。 接收到接收信号。 接收信号是发送信号的接收版本。 确定接收信号中的至少一个虚拟目标的存在。 在接收信号中缺少虚拟目标的存在提供了FMCW雷达设备的硬件故障的指示。
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公开(公告)号：US20120316190A1
公开(公告)日：2012-12-13
申请号：US13483932
申请日：2012-05-30
IPC分类号： A61K31/485 , A61P1/00
CPC分类号： A61K31/485 , A61K31/445
摘要： The invention provides prophylactic and therapeutic methods for administering a μ-opioid receptor antagonist, e.g., N-methylnaltrexone or a salt thereof, to treat cell barrier diseases and disorders, such as endothelial and epithelial cell barrier diseases and disorders, e.g., inflammatory bowel disease. Methods of reducing the symptoms of inflammatory bowel disease and the risk of developing inflammatory bowel disease are also provided.
摘要翻译： 本发明提供了用于施用μ-阿片受体拮抗剂（例如N-甲基纳曲酮或其盐）以治疗细胞屏障疾病和病症（例如内皮和上皮细胞屏障疾病和病症，例如炎症性肠病）的预防和治疗方法 。 还提供了减少炎症性肠病的症状和发展为炎性肠病的风险的方法。
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