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    Use of methylnaltrexone and related compounds to treat chronic opioid use side affects
    3.
    发明授权
    Use of methylnaltrexone and related compounds to treat chronic opioid use side affects 有权
    使用甲基纳曲酮及其相关化合物治疗慢性阿片类药物使用方面的影响

    公开(公告)号：US06559158B1

    公开(公告)日：2003-05-06

    申请号：US09669358

    申请日：2000-09-26

    申请人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    发明人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    IPC分类号： A61K31485

    CPC分类号： A61K31/485

    摘要： A method of preventing or treating an opioid-induced side effect in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.

    摘要翻译： 一种在长期摄取阿片样物质的患者中预防或治疗阿片样物质诱导的副作用的方法，所述方法包括以足以防止或治疗患者副作用的量施用去甲吗啡酮的季衍生物， 不足以治疗没有长期服用阿片类药物的相同阿片样物质诱导的副作用的患者。

    Alarm upon detection of impending sleep state
    4.
    发明授权
    Alarm upon detection of impending sleep state 有权
    在检测即将到来的睡眠状态时发出报警

    公开(公告)号：US06497658B2

    公开(公告)日：2002-12-24

    申请号：US09737682

    申请日：2000-12-15

    申请人： Michael F. Roizen ,  Lawrence J. Gottlieb ,  Avery Tung

    发明人： Michael F. Roizen ,  Lawrence J. Gottlieb ,  Avery Tung

    IPC分类号： A61B500

    CPC分类号： A61M21/02 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/18 ,  A61B5/4809 ,  A61M2021/0022 ,  A61M2021/0027 ,  A61M2021/0044 ,  A61M2230/10 ,  A61M2230/60

    摘要： The present invention monitors a physiological process intrinsic to humans and which measures directly the approach of a sleep state. When sleep onset is detected, the subject is restored to a fully awake state by an alert mechanism. Sleep onset is determined by monitoring EEG and EMG signals of the subject with a bispectral index monitor and applying an analysis algorithm to the index values output by the monitor. As a person tires, the value of their bispectral index begins to drop and then oscillate back and forth between two discrete levels. This pattern is consistent among various subjects and indicates an early warning of impending sleep, before a dangerous loss of vigilance has occurred.

    摘要翻译： 本发明监测人类固有的生理过程，并且直接测量睡眠状态的方法。 当检测到睡眠开始时，通过警报机制将被摄体恢复到完全清醒状态。 通过用双谱指数监测器监测受试者的EEG和EMG信号并将分析算法应用于由监测器输出的指数值来确定睡眠发作。 作为一个人，轮胎的双轴指数的价值开始下降，然后在两个离散的水平之间来回摆动。 这种模式在各种主题之间是一致的，并且表示在即将发生睡眠之前提前警告即将发生的警觉。

    AUTOMATED COACHING
    6.
    发明申请
    AUTOMATED COACHING 审中-公开
    自动教练

    公开(公告)号：US20100179833A1

    公开(公告)日：2010-07-15

    申请号：US12649661

    申请日：2009-12-30

    申请人： MICHAEL F. ROIZEN ,  Mehmet C. Oz ,  Jeffrey D. Roizen

    发明人： MICHAEL F. ROIZEN ,  Mehmet C. Oz ,  Jeffrey D. Roizen

    IPC分类号： G06Q50/00 ,  G06Q10/00 ,  G06F3/01

    CPC分类号： G06Q50/10 ,  G06Q50/2057 ,  G06Q50/22 ,  G06Q50/24

    摘要： System and methods are disclosed that provide a coaching system that is programmed to process data entered automatically or manually for a given client and determine an indication of progress for the given client according to a coaching plan designed for the client. A response generator automatically generates a personalized response for the given client depending on the indication of progress for the given client, which response can be sent to the given client with or without first being reviewed by the client's coach.

    摘要翻译： 公开了提供一种辅导系统，其被编程为处理为给定客户端自动或手动输入的数据，并根据为客户设计的辅导计划确定给定客户端的进度指示。 响应发生器根据给定客户的进度指示，自动生成针对给定客户端的个性化响应，哪个响应可以被发送给给定的客户端，有或者没有首先被客户的教练审查。

    Methods and Systems for Improving Human Health Using Targeted Probiotics
    7.
    发明申请
    Methods and Systems for Improving Human Health Using Targeted Probiotics 有权
    使用目标益生菌改善人类健康的方法和系统

    公开(公告)号：US20090287506A1

    公开(公告)日：2009-11-19

    申请号：US12466750

    申请日：2009-05-15

    申请人： Michael F. Roizen ,  Mehmet C. Oz

    发明人： Michael F. Roizen ,  Mehmet C. Oz

    IPC分类号： G06Q50/00 ,  G06Q90/00

    CPC分类号： G06F19/322 ,  G06F19/00 ,  G06F19/326 ,  G06F19/3456 ,  G06Q50/22 ,  G06Q50/24 ,  G06Q99/00 ,  G16H10/60 ,  Y02A90/22 ,  Y02A90/26

    摘要： Methods and systems enable healthcare providers to identify metabolites that may cause a medical condition in a patient. The healthcare providers may then use the identified metabolite to identify a probiotic that may affect the regulation of that metabolite. Patient information, such as medical history and diagnosis data may then be used in combination with the identified probiotic to create a personalized medicament for that patient.

    摘要翻译： 方法和系统使医疗保健提供者能够识别可能导致患者医疗状况的代谢物。 医疗保健提供者然后可以使用鉴定的代谢物来鉴定可能影响该代谢物调节的益生菌。 然后可以将患者信息（例如病史和诊断数据）与所鉴定的益生菌组合使用以为该患者创建个性化药物。

    Use of methylnaltrexone and related compounds
    8.
    发明授权
    Use of methylnaltrexone and related compounds 有权
    使用甲基纳曲酮及其相关化合物

    公开(公告)号：US06608075B2

    公开(公告)日：2003-08-19

    申请号：US09862169

    申请日：2001-05-21

    申请人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    发明人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    IPC分类号： A61K31485

    CPC分类号： A61K31/485

    摘要： A method for preventing or treating opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.

    摘要翻译： 一种预防或治疗阿片样物质诱导胃肠蠕动变化的方法。 所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物以肠溶包衣形式口服给药 。

    Use of methylnaltrexone and related compounds
    9.
    发明授权
    Use of methylnaltrexone and related compounds 失效
    使用甲基纳曲酮及其相关化合物

    公开(公告)号：US06274591B1

    公开(公告)日：2001-08-14

    申请号：US09120703

    申请日：1998-07-22

    申请人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    发明人： Joseph F. Foss ,  Michael F. Roizen ,  Jonathan Moss ,  Chun-Su Yuan ,  William Drell

    IPC分类号： A61K31448

    CPC分类号： A61K31/485

    摘要： A method for preventing or treating the opioid induced side effect, inhibition of gastrointestinal motility is disclosed. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.

    摘要翻译： 公开了一种预防或治疗阿片样物质诱导的副作用，抑制胃肠蠕动的方法。 所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物以肠溶包衣形式口服给药 。