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    Recombinant Anti-Cd30 Antibodies and Uses Thereof
    1.
    发明申请
    Recombinant Anti-Cd30 Antibodies and Uses Thereof 审中-公开
    重组抗Cd30抗体及其用途

    公开(公告)号：US20070258987A1

    公开(公告)日：2007-11-08

    申请号：US10558811

    申请日：2004-05-28

    申请人： Joseph Francisco ,  Grant Risdon ,  Alan Wahl ,  Clay Siegall ,  Peter Senter ,  Doronina Svetlana ,  Brian Toki

    发明人： Joseph Francisco ,  Grant Risdon ,  Alan Wahl ,  Clay Siegall ,  Peter Senter ,  Doronina Svetlana ,  Brian Toki

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/3061 ,  C07K2317/73

    摘要： The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's disease cells in the absence of effector cells or complement. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.

    摘要翻译： 本发明涉及用于治疗霍奇金病的方法和组合物，其包括给予特征为结合CD30的能力的蛋白质，或与单克隆抗体AC10或HeFi-1竞争结合CD30，并对细胞生长抑制或细胞毒性作用 霍奇金病细胞在没有效应细胞或补体的情况下。 这些蛋白质包括单克隆抗体AC10和HeFi-1的衍生物。 本发明的蛋白质可以是人，人源化或嵌合抗体; 此外，它们可以与细胞毒性剂如化学治疗药物缀合。 本发明还涉及编码本发明蛋白质的核酸。 本发明还涉及用于鉴定可用于治疗或预防霍奇金病的抗CD30抗体的方法。

    Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders
    9.
    发明申请
    Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders 审中-公开
    抗CD20抗体 - 药物共轭物，用于治疗癌症和免疫疾病

    公开(公告)号：US20050180972A1

    公开(公告)日：2005-08-18

    申请号：US10632151

    申请日：2003-07-30

    申请人： Alan Wahl ,  Peter Senter ,  Che-Leung Law ,  Charles Cerveny

    发明人： Alan Wahl ,  Peter Senter ,  Che-Leung Law ,  Charles Cerveny

    IPC分类号： A61K39/395 ,  A61K47/48 ,  C07K16/46

    CPC分类号： A61K47/6851 ,  A61K47/6849

    摘要： The present invention relates to methods and compositions for the treatment of CD20-expressing cancers and immune disorders involving CD20-expressing cells. The present methods comprise administering to a subject an anti CD20 antibody-drug conjugate that has a high potency and/or is capable of internalizing into CD20-expressing cells. The present invention further provides pharmaceutical compositions and kits comprising such conjugates. The present invention yet further provides methods of and compositions relating to combination therapy of cancer and immune disorders involving CD20-expressing cells using the anti-CD20 antibody-drug conjugates of the invention.

    摘要翻译： 本发明涉及用于治疗表达CD20的癌症和涉及CD20表达细胞的免疫疾病的方法和组合物。 本发明的方法包括向受试者施用具有高效力和/或能够内化成CD20表达细胞的抗CD20抗体 - 药物偶联物。 本发明还提供了包含这种缀合物的药物组合物和试剂盒。 本发明还进一步提供了使用本发明的抗CD20抗体 - 药物共轭物的癌症和涉及CD20表达细胞的免疫疾病的组合疗法的方法和组合物。