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    Thiazine derivatives
    2.
    发明授权
    Thiazine derivatives 失效
    噻嗪衍生物

    公开(公告)号：US4180662A

    公开(公告)日：1979-12-25

    申请号：US938274

    申请日：1978-08-31

    申请人： Rudolf Pfister ,  Paul Zeller ,  Dieter Binder ,  Otto Hromatka

    发明人： Rudolf Pfister ,  Paul Zeller ,  Dieter Binder ,  Otto Hromatka

    IPC分类号： A61K31/54 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  C07D333/34 ,  C07D333/38 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D333/34 ,  C07D333/38

    摘要： Anti-inflammatory, analgesic, anti-rheumatic and anti-thrombotic thienothiazine derivatives having the formula ##STR1## wherein A together with the two carbon atoms forms the group ##STR2## and the dotted line indicates the double bond present in the first and last thieno structures above, R.sup.1 is lower alkyl, R.sup.2 is the radical of an aromatic heterocycle with 1 to 4 hetero atoms optionally substituted by one or two lower alkyl groups, or a phenyl radical optionally substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy, R.sup.3 is halogen and R.sup.3' is hydrogen or halogen,and pharmaceutically acceptable salts thereof are described.

    摘要翻译： 具有下式的抗炎，止痛，抗风湿和抗血栓形成噻吩噻嗪衍生物其中A与两个碳原子一起形成基团，虚线表示存在于第一和最后一个 R 1为低级烷基，R 2为任选被一个或两个低级烷基取代的具有1至4个杂原子的芳族杂环的基团，或任选被卤素，羟基，低级烷基，三氟甲基或低级烷基取代的苯基 烷氧基，R 3为卤素，R 3'为氢或卤素，及其药学上可接受的盐。

    Thienothiazine derivatives
    4.
    发明授权
    Thienothiazine derivatives 失效
    噻吩嗪衍生物

    公开(公告)号：US4175085A

    公开(公告)日：1979-11-20

    申请号：US882723

    申请日：1978-03-02

    申请人： Dieter Binder ,  Otto Hromatka ,  Rudolf Pfister ,  Paul Zeller

    发明人： Dieter Binder ,  Otto Hromatka ,  Rudolf Pfister ,  Paul Zeller

    IPC分类号： C07D333/34 ,  C07D333/38 ,  C07D333/24 ,  A01N9/00

    CPC分类号： C07D333/38 ,  C07D333/34

    摘要： Thienothiazine derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl; R.sub.2 is an unsubstituted aromatic heterocyclic radical which contains from 1 to 4 hetero atoms or one which is substituted by one or two lower alkyl groups, or is an unsubstituted phenyl radical or one substituted by halogen, hydroxy, lower alkyl, nitro, trifluoromethyl or lower alkoxy; and R.sub.3 and R.sub.4, independently, are hydrogen or lower alkyl,prepared inter alia, from novel intermediates, are described. The end products are useful as anti-inflammatory, analgesic and anti-rheumatic agents.

    摘要翻译： 式I的噻吩并噻嗪衍生物，其中R 1是低级烷基; R2是未取代的芳族杂环基，其含有1至4个杂原子或被一个或两个低级烷基取代的芳族杂环基，或是未被取代的苯基或被卤素，羟基，低级烷基，硝基，三氟甲基或低级 烷氧基 R 3和R 4独立地是氢或低级烷基，特别是由新的中间体制备。 最终产品可用作抗炎，镇痛和抗风湿药。

    Thienothiazines
    5.
    发明授权
    Thienothiazines 失效
    噻吩嗪

    公开(公告)号：US4076709A

    公开(公告)日：1978-02-28

    申请号：US606563

    申请日：1975-08-21

    申请人： Otto Hromatka ,  Dieter Binder ,  Rudolf Pfister ,  Paul Zeller

    发明人： Otto Hromatka ,  Dieter Binder ,  Rudolf Pfister ,  Paul Zeller

    IPC分类号： C07D333/38 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D333/38

    摘要： The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## AND THE BROKEN LINE REPRESENTS THE DOUBLE BOND IN GROUP (A); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and antirheumatic activity.

    摘要翻译： 本发明涉及下式的化合物：其中A与其所连接的两个碳原子一起形成组（A），并且断线表示组（A）中的双键; R1表示低级烷基; R2表示可以被一个或两个低级烷基取代的含有1至4个杂原子的芳族杂环的残基或可以被卤素，羟基，低级烷基，三氟甲基或低级烷氧基取代的苯基， R3和R4各自表示氢原子或低级烷基。

    Thienothiazine derivatives
    6.
    发明授权
    Thienothiazine derivatives 失效
    噻吩嗪衍生物

    公开(公告)号：US4224445A

    公开(公告)日：1980-09-23

    申请号：US955568

    申请日：1978-10-30

    申请人： Otto Hromatka ,  Dieter Binder ,  Rudolf Pfister ,  Paul Zeller

    发明人： Otto Hromatka ,  Dieter Binder ,  Rudolf Pfister ,  Paul Zeller

    IPC分类号： C07D333/38 ,  C07D513/04 ,  C07D333/40

    CPC分类号： C07D513/04 ,  C07D333/38

    摘要： The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## and the broken line represents the double bond in group (a); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and anti-rheumatic activity.

    摘要翻译： 本发明涉及下式化合物其中A与连接的两个碳原子一起形成基团，虚线代表组（a）中的双键; R1表示低级烷基; R2表示可以被一个或两个低级烷基取代的含有1至4个杂原子的芳族杂环的残基或可以被卤素，羟基，低级烷基，三氟甲基或低级烷氧基取代的苯基， R3和R4各自表示氢原子或低级烷基。 还提供了它们的制备方法。 本发明提供的噻吩并噻嗪衍生物具有抗炎，镇痛和抗风湿活性。

    Thienothiazine derivatives
    8.
    发明授权
    Thienothiazine derivatives 失效
    噻吩嗪衍生物

    公开(公告)号：US4177193A

    公开(公告)日：1979-12-04

    申请号：US955567

    申请日：1978-10-30

    申请人： Otto Hromatka ,  Dieter Binder ,  Rudolf Pfister ,  Paul Zeller

    发明人： Otto Hromatka ,  Dieter Binder ,  Rudolf Pfister ,  Paul Zeller

    IPC分类号： C07D333/38 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D333/38

    摘要： The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## and the broken line represents the double bond in group (a); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and anti-rheumatic activity.

    摘要翻译： 本发明涉及下式化合物其中A与连接的两个碳原子一起形成基团，虚线代表组（a）中的双键; R1表示低级烷基; R2表示可以被一个或两个低级烷基取代的含有1至4个杂原子的芳族杂环的残基或可以被卤素，羟基，低级烷基，三氟甲基或低级烷氧基取代的苯基， R3和R4各自表示氢原子或低级烷基。 还提供了它们的制备方法。 本发明提供的噻吩并噻嗪衍生物具有抗炎，镇痛和抗风湿活性。

    N-Carbalkoxymethylsulfamoyl thiophene carboxylic acid alkyl esters
    9.
    发明授权
    N-Carbalkoxymethylsulfamoyl thiophene carboxylic acid alkyl esters 失效
    N-烷氧基甲基氨磺酰基噻吩羧酸烷基酯

    公开(公告)号：US4134898A

    公开(公告)日：1979-01-16

    申请号：US852385

    申请日：1977-11-17

    申请人： Otto Hromatka ,  Dieter Binder ,  Rudolf Pfister ,  Paul Zeller

    发明人： Otto Hromatka ,  Dieter Binder ,  Rudolf Pfister ,  Paul Zeller

    IPC分类号： C07D333/38

    CPC分类号： C07D333/38

    摘要： The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## AND THE BROKEN LINE REPRESENTS THE DOUBLE BOND IN GROUP (A); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.

    摘要翻译： 本发明涉及下式的化合物：其中A与其所连接的两个碳原子一起形成组（A），并且断线表示组（A）中的双键; R1表示低级烷基; R2表示可以被一个或两个低级烷基取代的含有1至4个杂原子的芳族杂环的残基或可以被卤素，羟基，低级烷基，三氟甲基或低级烷氧基取代的苯基， R3和R4各自表示氢原子或低级烷基。

    Thienothiazine derivatives
    10.
    发明授权
    Thienothiazine derivatives 失效
    噻吩嗪衍生物

    公开(公告)号：US4090020A

    公开(公告)日：1978-05-16

    申请号：US767016

    申请日：1977-02-09

    申请人： Dieter Binder ,  Otto Hromatka ,  Rudolf Pfister ,  Paul Zeller

    发明人： Dieter Binder ,  Otto Hromatka ,  Rudolf Pfister ,  Paul Zeller

    IPC分类号： A61K31/54 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  C07D333/34 ,  C07D333/38 ,  C07D513/04 ,  A61K31/38

    CPC分类号： C07D513/04 ,  C07D333/34 ,  C07D333/38

    摘要： Thienothiazine derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl; R.sub.2 is an unsubstituted aromatic heterocyclic radical which contains from 1 to 4 hetero atoms or one which is substituted by one or two lower alkyl groups, or is an unsubstituted phenyl radical or one substituted by halogen, hydroxy, lower alkyl, nitro, trifluoromethyl or lower alkoxy; and R.sub.3 and R.sub.4, independently, are hydrogen or lower alkyl,Prepared inter alia, from novel intermediates, are described. The end products are useful as anti-inflammatory, analgesic and anti-rheumatic agents.

    摘要翻译： 式I的噻吩并噻嗪衍生物，其中R 1是低级烷基; R2是未取代的芳族杂环基，其含有1至4个杂原子或被一个或两个低级烷基取代的芳族杂环基，或是未被取代的苯基或被卤素，羟基，低级烷基，硝基，三氟甲基或低级 烷氧基 并且R3和R4独立地是氢或低级烷基，来自新式中间体的制备的相互作用。 最终产品可用作抗炎，镇痛和抗风湿药。