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1.N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors 失效
标题翻译: N-取代的吡唑基 - 氨基 - 苯并咪唑基c-Kit抑制剂公开(公告)号:US07485658B2
公开(公告)日:2009-02-03
申请号:US10919973
申请日:2004-08-16
申请人: Joshua Bolger , Arlindo L. Castelhano , Andrew Phillip Crew , Radoslaw Laufer , An-Hu Li , Colin Peter Sambrook Smith , Yingchuan Sun
发明人: Joshua Bolger , Arlindo L. Castelhano , Andrew Phillip Crew , Radoslaw Laufer , An-Hu Li , Colin Peter Sambrook Smith , Yingchuan Sun
IPC分类号: A61K31/4184 , C07D403/02
CPC分类号: C07D403/12
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐或N-氧化物可用于治疗癌症。
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公开(公告)号:US07521448B2
公开(公告)日:2009-04-21
申请号:US10921414
申请日:2004-08-16
申请人: Joshua Bolger , Arlindo L. Castelhano , Andrew Phillip Crew , Han-Qing Dong , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Li Qiu , Colin Peter Sambrook Smith , Yingchaun Sun , Graham Michael Wynne , Tao Zhang
发明人: Joshua Bolger , Arlindo L. Castelhano , Andrew Phillip Crew , Han-Qing Dong , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Li Qiu , Colin Peter Sambrook Smith , Yingchaun Sun , Graham Michael Wynne , Tao Zhang
IPC分类号: A61K31/5377 , C07D413/12
CPC分类号: C07D235/06 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐或N-氧化物可用于治疗癌症。
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公开(公告)号:US20090062275A1
公开(公告)日:2009-03-05
申请号:US12209862
申请日:2008-09-12
申请人: Arlindo L. Castelhano , Andrew Phillip Crew , Han-Qing Dong , Radoslaw Laufer , An-Hu Li , Li Qiu , Colin Peter Sambrook Smith , Tao Zhang
发明人: Arlindo L. Castelhano , Andrew Phillip Crew , Han-Qing Dong , Radoslaw Laufer , An-Hu Li , Li Qiu , Colin Peter Sambrook Smith , Tao Zhang
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/437
CPC分类号: C07D471/04
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐或N-氧化物可用于治疗癌症。
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公开(公告)号:US07442709B2
公开(公告)日:2008-10-28
申请号:US10921418
申请日:2004-08-16
申请人: Arlindo L. Castelhano , Andrew Phillip Crew , Han-Qing Dong , Radoslaw Laufer , An-Hu Li , Li Qiu , Colin Peter Sambrook Smith , Tao Zhang
发明人: Arlindo L. Castelhano , Andrew Phillip Crew , Han-Qing Dong , Radoslaw Laufer , An-Hu Li , Li Qiu , Colin Peter Sambrook Smith , Tao Zhang
IPC分类号: A61K31/44 , C07D471/02 , C07D491/02
CPC分类号: C07D471/04
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐或N-氧化物可用于治疗癌症。
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公开(公告)号:US07767673B2
公开(公告)日:2010-08-03
申请号:US12209862
申请日:2008-09-12
申请人: Arlindo L. Castelhano , Andrew P. Crew , Han-Qing Dong , Radoslaw Laufer , An-Hu Li , Li Qiu , Colin Peter Sambrook Smith , Tao Zhang
发明人: Arlindo L. Castelhano , Andrew P. Crew , Han-Qing Dong , Radoslaw Laufer , An-Hu Li , Li Qiu , Colin Peter Sambrook Smith , Tao Zhang
IPC分类号: A61K31/5377 , C07D413/12
CPC分类号: C07D471/04
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-Oxide thereof, are useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐或N-氧化物可用于治疗癌症。
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公开(公告)号:US20060035951A1
公开(公告)日:2006-02-16
申请号:US10919973
申请日:2004-08-16
申请人: Joshua Bolger , Arlindo Castelhano , Andrew Crew , Radoslaw Laufer , An-Hu Li , Colin Sambrook Smith , Yingchuan Sun
发明人: Joshua Bolger , Arlindo Castelhano , Andrew Crew , Radoslaw Laufer , An-Hu Li , Colin Sambrook Smith , Yingchuan Sun
IPC分类号: A61K31/4184 , C07D403/02
CPC分类号: C07D403/12
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
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7.N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors 失效
标题翻译: N-取代的吡唑基 - 氨基 - 苯并咪唑基c-Kit抑制剂公开(公告)号:US20080221187A9
公开(公告)日:2008-09-11
申请号:US10919973
申请日:2004-08-16
申请人: Joshua Bolger , Arlindo Castelhano , Andrew Crew , Radoslaw Laufer , An-Hu Li , Colin Sambrook Smith , Yingchuan Sun
发明人: Joshua Bolger , Arlindo Castelhano , Andrew Crew , Radoslaw Laufer , An-Hu Li , Colin Sambrook Smith , Yingchuan Sun
IPC分类号: A61K31/4184 , C07D403/02
CPC分类号: C07D403/12
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐或N-氧化物可用于治疗癌症。
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8.
公开(公告)号:US20060235031A1
公开(公告)日:2006-10-19
申请号:US11095162
申请日:2005-03-31
申请人: Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: A61K31/52
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 下式的化合物及其药学上可接受的盐,其中X 1,X 2,X 3,X 4, X 5,X 6,X 7,R 1和Q 1 在本文中定义,抑制IGF-1R酶,并且可用于治疗和/或预防过度增殖性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢的疾病和状况 神经系统。
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公开(公告)号:US20120196847A1
公开(公告)日:2012-08-02
申请号:US13446629
申请日:2012-04-13
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: A61K31/4985 , A61K31/53 , A61P35/00 , A61K31/5377 , A61K31/551 , C07D487/04 , A61K31/519
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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10.
公开(公告)号:US08101613B2
公开(公告)日:2012-01-24
申请号:US12540047
申请日:2009-08-12
申请人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
发明人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
IPC分类号: A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D471/00 , C07D487/00
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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