Osmotic system for delivery of fluid-sensitive somatotropins to bovine
animals
    3.
    发明授权
    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals 失效
    用于将流体敏感生长激素递送至牛类动物的渗透系统

    公开(公告)号:US5728088A

    公开(公告)日:1998-03-17

    申请号:US269596

    申请日:1994-07-01

    摘要: A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may include means for adapting the end cap for ultrasonic welding to the first wall section and means for maintaining the beneficial agent in contact with exit means. The compartment comprises a beneficial agent and an expandable means. The delivery system comprises exit means for delivering the beneficial agent to the animal. The exit means may include means for compensating for slight variations in the efflux rate of the beneficial agent and means for maintaining for a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.

    摘要翻译: 公开了一种递送系统,用于将诸如生长激素或其类似物或衍生物的流体敏感的有益药物递送到动物例如牛。 输送系统包括围绕内部隔室的壁,所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 所述壁还可以包括端盖,所述端盖可以包括用于使用于超声波焊接的端盖适配到第一壁部分的装置和用于保持有益剂与出口装置接触的装置。 隔室包括有益剂和可膨胀装置。 递送系统包括用于将有益剂递送到动物的出口装置。 出口装置可以包括用于补偿有益剂的流出速率的轻微变化的装置和用于维持有益剂从装置向外的足够的速度或流出速率的装置,同时最小化流体从外部环境扩散回装置 。

    Implantable delivery dispenser
    4.
    发明授权
    Implantable delivery dispenser 失效
    可搬运分配器

    公开(公告)号:US5112614A

    公开(公告)日:1992-05-12

    申请号:US407489

    申请日:1989-09-14

    IPC分类号: A61K9/00 A61K9/22

    CPC分类号: A61K9/0004

    摘要: An implantable dispenser is enclosed comprising a wall surrounding a compartment containing a first composition comprising a beneficial agent, an oil, a cosolvent and a polymer gellant, a second expandable composition, a third boundary maintaining composition between the first and second composition, and an exit port.

    摘要翻译: 封闭的可植入分配器包括围绕包含第一组合物的隔室的壁,第一组合物包含有益剂,油,助溶剂和聚合物胶凝剂,第二可膨胀组合物,第一和第二组合物之间的第三边界保持组合物,以及出口 港口。

    Polyurethane-containing delivery systems
    8.
    发明授权
    Polyurethane-containing delivery systems 失效
    含聚氨酯的输送系统

    公开(公告)号:US06180129B2

    公开(公告)日:2001-01-30

    申请号:US08956424

    申请日:1997-10-23

    IPC分类号: A61K914

    CPC分类号: A61K9/0004 A61M31/002

    摘要: A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.

    摘要翻译: 公开了用于将有益剂递送到动物的递送系统。 递送系统包括围绕内腔的壁,所述壁包括限制流体进入系统的组合物和允许流体进入系统的组合物。 管腔包括有益剂和可膨胀构件。 递送系统包括用于递送有益剂的出口装置。