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    Implantable system for delivery of fluid-sensitive agents to animals
    1.
    发明授权
    Implantable system for delivery of fluid-sensitive agents to animals 失效
    用于向动物输送流体敏感剂的植入系统

    公开(公告)号：US5871770A

    公开(公告)日：1999-02-16

    申请号：US947031

    申请日：1997-10-08

    申请人： Judy A. Magruder ,  James B. Eckenhoff, deceased ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    发明人： Judy A. Magruder ,  James B. Eckenhoff, deceased ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    IPC分类号： A61K9/00 ,  A61K9/52 ,  A61F2/02 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure. The passageway (13) is preferably sized to compensate for slight variations in the efflux of the beneficial agent and to maintaining a sufficient volumetric outflow rate of beneficial agent in order to minimize influx of biological fluids from the external environment back into the device once the seal (30) is expelled.

    摘要翻译： 公开了用于将诸如生长激素或其类似物或衍生物的流体敏感有益试剂（7）递送给动物如牛的递送系统（10）。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 提供出口通道用于将有益剂输送到动物的内部隔室（18）。 出口通道用蜡密封件（30）密封，当密封件（10）中的内部压力达到预定的“爆裂”压力时，该密封件通过通道（13）排出。 通道（13）优选的尺寸适于补偿有益剂的流出中的轻微变化并维持有益剂的足够的体积流出速率，以便最小化生物流体从外部环境流入装置中，一旦密封 （30）被排出。

    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
    2.
    发明授权
    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals 失效
    用于将流体敏感生长激素递送至牛类动物的渗透系统

    公开(公告)号：US5728088A

    公开(公告)日：1998-03-17

    申请号：US269596

    申请日：1994-07-01

    申请人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    发明人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    IPC分类号： A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M31/00

    CPC分类号： A61K9/0004 ,  A61D7/00 ,  A61M31/002

    摘要： A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may include means for adapting the end cap for ultrasonic welding to the first wall section and means for maintaining the beneficial agent in contact with exit means. The compartment comprises a beneficial agent and an expandable means. The delivery system comprises exit means for delivering the beneficial agent to the animal. The exit means may include means for compensating for slight variations in the efflux rate of the beneficial agent and means for maintaining for a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.

    摘要翻译： 公开了一种递送系统，用于将诸如生长激素或其类似物或衍生物的流体敏感的有益药物递送到动物例如牛。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 所述壁还可以包括端盖，所述端盖可以包括用于使用于超声波焊接的端盖适配到第一壁部分的装置和用于保持有益剂与出口装置接触的装置。 隔室包括有益剂和可膨胀装置。 递送系统包括用于将有益剂递送到动物的出口装置。 出口装置可以包括用于补偿有益剂的流出速率的轻微变化的装置和用于维持有益剂从装置向外的足够的速度或流出速率的装置，同时最小化流体从外部环境扩散回装置 。

    Implantable system for delivery of fluid-sensitive agents to animals
    3.
    发明授权
    Implantable system for delivery of fluid-sensitive agents to animals 失效
    用于向动物输送流体敏感剂的植入系统

    公开(公告)号：US5690952A

    公开(公告)日：1997-11-25

    申请号：US485870

    申请日：1995-06-07

    申请人： Judy A. Magruder ,  James B. Eckenhoff, deceased ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    发明人： Judy A. Magruder ,  James B. Eckenhoff, deceased ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    IPC分类号： A61K9/00 ,  A61K9/52 ,  A61F2/02 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure. The passageway (13) is preferably sized to compensate for slight variations in the efflux of the beneficial agent and to maintaining a sufficient volumetric outflow rate of beneficial agent in order to minimize influx of biological fluids from the external environment back into the device once the seal (30) is expelled.

    摘要翻译： 公开了用于将诸如生长激素或其类似物或衍生物的流体敏感有益试剂（7）递送给动物如牛的递送系统（10）。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 提供出口通道用于将有益剂输送到动物的内部隔室（18）。 出口通道用蜡密封件（30）密封，当密封件（10）中的内部压力达到预定的“爆裂”压力时，该密封件通过通道（13）排出。 通道（13）优选的尺寸适于补偿有益剂的流出中的轻微变化并维持有益剂的足够的体积流出速率，以便最小化生物流体从外部环境流入装置中，一旦密封 （30）被排出。

    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
    4.
    发明授权
    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals 失效
    用于将流体敏感生长激素递送至牛类动物的渗透系统

    公开(公告)号：US5980509A

    公开(公告)日：1999-11-09

    申请号：US976513

    申请日：1997-11-24

    申请人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    发明人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    IPC分类号： A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M31/00

    CPC分类号： A61K9/0004 ,  A61D7/00 ,  A61M31/002

    摘要： A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may be adapted for ultrasonic welding to the first wall section and may maintain the beneficial agent in contact with an exit. The compartment comprises a beneficial agent and an expandable driving member. The delivery system comprises an exit for delivering the beneficial agent to the animal. The exit may compensate for slight variations in the efflux rate of the beneficial agent and maintain a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.

    摘要翻译： 公开了一种递送系统，用于将诸如生长激素或其类似物或衍生物的流体敏感的有益药物递送到动物例如牛。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 壁可以进一步包括可适于超声波焊接到第一壁部分的端盖，并且可以使有益剂保持与出口接触。 隔室包括有益剂和可膨胀的驱动构件。 递送系统包括用于将有益药物递送给动物的出口。 出口可以补偿有益剂的流出速率的轻微变化，并将有益药剂从装置向外保持足够的速度或流出速率，同时使流体从外部环境扩散回到装置中。