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公开(公告)号：US5871770A
公开(公告)日：1999-02-16
申请号：US947031
申请日：1997-10-08
申请人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
发明人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
CPC分类号： A61K9/0004
摘要： A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure. The passageway (13) is preferably sized to compensate for slight variations in the efflux of the beneficial agent and to maintaining a sufficient volumetric outflow rate of beneficial agent in order to minimize influx of biological fluids from the external environment back into the device once the seal (30) is expelled.
摘要翻译： 公开了用于将诸如生长激素或其类似物或衍生物的流体敏感有益试剂（7）递送给动物如牛的递送系统（10）。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 提供出口通道用于将有益剂输送到动物的内部隔室（18）。 出口通道用蜡密封件（30）密封，当密封件（10）中的内部压力达到预定的“爆裂”压力时，该密封件通过通道（13）排出。 通道（13）优选的尺寸适于补偿有益剂的流出中的轻微变化并维持有益剂的足够的体积流出速率，以便最小化生物流体从外部环境流入装置中，一旦密封 （30）被排出。
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2.发明授权Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals 失效用于将流体敏感生长激素递送至牛类动物的渗透系统
公开(公告)号：US5980509A
公开(公告)日：1999-11-09
申请号：US976513
申请日：1997-11-24
申请人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
发明人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
CPC分类号： A61K9/0004 , A61D7/00 , A61M31/002
摘要： A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may be adapted for ultrasonic welding to the first wall section and may maintain the beneficial agent in contact with an exit. The compartment comprises a beneficial agent and an expandable driving member. The delivery system comprises an exit for delivering the beneficial agent to the animal. The exit may compensate for slight variations in the efflux rate of the beneficial agent and maintain a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.
摘要翻译： 公开了一种递送系统，用于将诸如生长激素或其类似物或衍生物的流体敏感的有益药物递送到动物例如牛。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 壁可以进一步包括可适于超声波焊接到第一壁部分的端盖，并且可以使有益剂保持与出口接触。 隔室包括有益剂和可膨胀的驱动构件。 递送系统包括用于将有益药物递送给动物的出口。 出口可以补偿有益剂的流出速率的轻微变化，并将有益药剂从装置向外保持足够的速度或流出速率，同时使流体从外部环境扩散回到装置中。
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公开(公告)号：US5690952A
公开(公告)日：1997-11-25
申请号：US485870
申请日：1995-06-07
申请人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
发明人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
CPC分类号： A61K9/0004
摘要： A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure. The passageway (13) is preferably sized to compensate for slight variations in the efflux of the beneficial agent and to maintaining a sufficient volumetric outflow rate of beneficial agent in order to minimize influx of biological fluids from the external environment back into the device once the seal (30) is expelled.
摘要翻译： 公开了用于将诸如生长激素或其类似物或衍生物的流体敏感有益试剂（7）递送给动物如牛的递送系统（10）。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 提供出口通道用于将有益剂输送到动物的内部隔室（18）。 出口通道用蜡密封件（30）密封，当密封件（10）中的内部压力达到预定的“爆裂”压力时，该密封件通过通道（13）排出。 通道（13）优选的尺寸适于补偿有益剂的流出中的轻微变化并维持有益剂的足够的体积流出速率，以便最小化生物流体从外部环境流入装置中，一旦密封 （30）被排出。
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4.发明授权Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals 失效用于将流体敏感生长激素递送至牛类动物的渗透系统
公开(公告)号：US5728088A
公开(公告)日：1998-03-17
申请号：US269596
申请日：1994-07-01
申请人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
发明人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
CPC分类号： A61K9/0004 , A61D7/00 , A61M31/002
摘要： A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may include means for adapting the end cap for ultrasonic welding to the first wall section and means for maintaining the beneficial agent in contact with exit means. The compartment comprises a beneficial agent and an expandable means. The delivery system comprises exit means for delivering the beneficial agent to the animal. The exit means may include means for compensating for slight variations in the efflux rate of the beneficial agent and means for maintaining for a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.
摘要翻译： 公开了一种递送系统，用于将诸如生长激素或其类似物或衍生物的流体敏感的有益药物递送到动物例如牛。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 所述壁还可以包括端盖，所述端盖可以包括用于使用于超声波焊接的端盖适配到第一壁部分的装置和用于保持有益剂与出口装置接触的装置。 隔室包括有益剂和可膨胀装置。 递送系统包括用于将有益剂递送到动物的出口装置。 出口装置可以包括用于补偿有益剂的流出速率的轻微变化的装置和用于维持有益剂从装置向外的足够的速度或流出速率的装置，同时最小化流体从外部环境扩散回装置 。
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公开(公告)号：US5731001A
公开(公告)日：1998-03-24
申请号：US485877
申请日：1995-06-07
申请人： Judy A. Magruder , James B. Eckenhoff, deceased , Bonnie J. Eckenhoff , Edward V. Bourneuf , Richard Cortese , Jeremy C. Wright , John R. Peery , Ed Bourneuf , James B. Pike , Urano A. Robinson , John M. Sharockman , Jonathan P. Smith
发明人： Judy A. Magruder , James B. Eckenhoff, deceased , Bonnie J. Eckenhoff , Edward V. Bourneuf , Richard Cortese , Jeremy C. Wright , John R. Peery , Ed Bourneuf , James B. Pike , Urano A. Robinson , John M. Sharockman , Jonathan P. Smith
CPC分类号： A61K9/0004
摘要： A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a first wall section, a second wall section and a locking coupling therebetween. The coupled wall sections define a compartment, enclosing an active agent and an expandable driving member. Various embodiments of the locking coupling are disclosed.
摘要翻译： 公开了用于将诸如生长激素或其类似物或衍生物的流体敏感活性剂递送到动物如牛的递送系统。 输送系统包括第一壁部分，第二壁部分和它们之间的锁定联接。 耦合的壁部分限定了隔室，包围活性剂和可扩展的驱动构件。 公开了锁定联接器的各种实施例。
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公开(公告)号：US5922353A
公开(公告)日：1999-07-13
申请号：US947110
申请日：1997-10-08
申请人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , Edward V. Bourneuf , James B. Pike , Urano A. Robinson , John M. Sharockman , Jonathan P. Smith
发明人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , Edward V. Bourneuf , James B. Pike , Urano A. Robinson , John M. Sharockman , Jonathan P. Smith
CPC分类号： A61K9/0004
摘要： A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a first wall section, a second wall section and a locking coupling therebetween. The coupled wall sections define a compartment, enclosing an active agent and an expandable driving member. Various embodiments of the locking coupling are disclosed.
摘要翻译： 公开了用于将诸如生长激素或其类似物或衍生物的流体敏感活性剂递送到动物如牛的递送系统。 输送系统包括第一壁部分，第二壁部分和它们之间的锁定联接。 耦合的壁部分限定了隔室，包围活性剂和可扩展的驱动构件。 公开了锁定联接器的各种实施例。
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公开(公告)号：US5209746A
公开(公告)日：1993-05-11
申请号：US837183
申请日：1992-02-18
CPC分类号： A61K9/0004 , A61M5/14526 , A61M2005/14513 , A61M2206/10
摘要： Osmotically driven delivery capsules which include a beneficial agent and a water absorptive osmotic engine in separate compartments separated by a movable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a series of stops along the inner wall of the capsule which obstruct the movement of the partition but which are overcome in succession as the osmotic pressure rises above a threshold level. The number of stops and their placement longitudinally along the length of the capsule establish the number and frequency of the pulses, and the configuration of the partition controls the pulse intensity.
摘要翻译： 包括有益剂和吸水渗透引擎的渗透驱动输送胶囊被设计成以可动的方式通过孔传送有益剂。 通过沿着胶囊内壁的一系列止动件来实现脉动输送，其阻挡分隔件的移动，但随着渗透压上升到阈值水平以上，它们被连续克服。 沿着胶囊长度方向的停止次数及其位置纵向设置了脉冲的数量和频率，分区的配置控制了脉冲强度。
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公开(公告)号：US5308348A
公开(公告)日：1994-05-03
申请号：US58151
申请日：1993-05-05
CPC分类号： A61M5/14526 , A61K9/0004 , A61M2005/14513 , A61M2206/10
摘要： Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.
摘要翻译： 包括有益剂和活化机构的输送装置被设计成以可动的方式通过孔传送有益剂。 脉动输送通过放置在孔口上方的弹性材料带来实现。 当装置内的压力低于阈值水平时，同时能够在内部压力超过阈值时拉伸，弹性材料足够紧密以基本上密封孔口。
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公开(公告)号：US5456679A
公开(公告)日：1995-10-10
申请号：US352268
申请日：1994-12-07
CPC分类号： A61K9/0004 , A61M5/14526 , A61M2005/14513 , A61M2206/10
摘要： Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.
摘要翻译： 包括有益剂和活化机构的输送装置被设计成以可动的方式通过孔传送有益剂。 脉动输送通过放置在孔口上方的弹性材料带来实现。 当装置内的压力低于阈值水平时，同时能够在内部压力超过阈值时拉伸，弹性材料足够紧密以基本上密封孔口。
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