公开(公告)号：US20060009477A1

公开(公告)日：2006-01-12

申请号：US11152535

申请日：2005-06-14

申请人： Julius Matasi ,  Deen Tulshian ,  Duane Burnett ,  Wen-Lian Wu ,  Peter Korakas ,  Lisa Silverman ,  Thavalakulamgara Sasikumar ,  Li Qiang ,  Martin Domalski

发明人： Julius Matasi ,  Deen Tulshian ,  Duane Burnett ,  Wen-Lian Wu ,  Peter Korakas ,  Lisa Silverman ,  Thavalakulamgara Sasikumar ,  Li Qiang ,  Martin Domalski

IPC分类号： A61K31/519 ,  C07D487/14

CPC分类号： C07D471/14 ,  C07D491/14 ,  C07D495/04 ,  C07D495/14 ,  C09B57/00

摘要： In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J4, X, and R1—R5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

摘要翻译： 在其许多实施方案中，本发明提供了式I的三环化合物（其中J 1，X 4和X 1，R 2， 可用作代谢型谷氨酸受体（mGluR）拮抗剂，特别是作为选择性代谢型谷氨酸受体1拮抗剂的药物组合物，以及使用该化合物和组合物治疗疾病的治疗方法 与代谢型谷氨酸受体（例如，mGluR1）相关，例如疼痛，偏头痛，焦虑症，尿失禁和神经变性疾病如阿尔茨海默氏病。

公开(公告)号：US20060167029A1

公开(公告)日：2006-07-27

申请号：US11301672

申请日：2005-12-13

申请人： Julius Matasi ,  Deen Tulshian ,  Duane Burnett ,  Wen-Lian Wu ,  Peter Korakas ,  Lisa Silverman ,  Thavalakulamgara Sasikumar ,  Li Qiang ,  Martin Domalski

发明人： Julius Matasi ,  Deen Tulshian ,  Duane Burnett ,  Wen-Lian Wu ,  Peter Korakas ,  Lisa Silverman ,  Thavalakulamgara Sasikumar ,  Li Qiang ,  Martin Domalski

IPC分类号： A61K31/519 ,  C07D498/22

CPC分类号： C07D495/14

摘要： In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J4, X, and R1-R5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

摘要翻译： 在其许多实施方案中，本发明提供式I的三环化合物（其中J 1，X 4和X 1，R 2，R 2， 可用作代谢型谷氨酸受体（mGluR）拮抗剂，特别是作为选择性代谢型谷氨酸受体1拮抗剂的药物组合物，以及使用该化合物和组合物治疗疾病的治疗方法 与代谢型谷氨酸受体（例如，mGluR1）相关，例如疼痛，偏头痛，焦虑症，尿失禁和神经变性疾病如阿尔茨海默氏病。