公开(公告)号：US20240122862A1

公开(公告)日：2024-04-18

申请号：US17766722

申请日：2020-10-13

申请人： Julius-Maximilians-Universitaet Wuerzburg

发明人： Cornelius HERMANN ,  Lorenz MEINEL ,  Wolfgang SCHMEHL ,  Kevin POPP ,  Simon REILAENDER

IPC分类号： A61K9/48 ,  A61K33/04

CPC分类号： A61K9/485 ,  A61K9/4808 ,  A61K9/4816 ,  A61K33/04

摘要： The present invention discloses a therapeutic gas release system for oral administration comprising a therapeutic gas releasing compound A, and a therapeutic gas release triggering compound B, wherein compound A and B are separated from each other by an inner septum during storage of the system, wherein compound A and B are surrounded by an outer membrane, which is a gas-permeable and water- and solid-impermeable membrane, preferably a silicone membrane, and wherein therapeutic gas release from the system is activated before oral administration by breaking the inner septum. The therapeutic gas released from the system of the present invention is suitable for the treatment of (inflammatory) diseases of the gastrointestinal tract.