公开(公告)号：US08338420B1

公开(公告)日：2012-12-25

申请号：US12647880

申请日：2009-12-28

申请人： Jun Kotera ,  Takashi Sasaki ,  Takeo Kitazawa ,  Taketoshi Ishii ,  Hiroshi Morimoto ,  Harutami Yamada

发明人： Jun Kotera ,  Takashi Sasaki ,  Takeo Kitazawa ,  Taketoshi Ishii ,  Hiroshi Morimoto ,  Harutami Yamada

IPC分类号： A61K31/50 ,  A61K31/40 ,  C07D471/22

CPC分类号： A61K31/198 ,  A61K31/137 ,  A61K31/165 ,  A61K31/352 ,  A61K31/48 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/55 ,  C07D403/14 ,  A61K2300/00

摘要： The present invention relates to a therapeutic or prophylactic method for treating Parkinson's disease by administering an effective amount of a compound having a phosphodiesterase 10 inhibitory activity; and also relates to a pharmaceutical composition for treatment or prophylaxis of Parkinson's disease comprising as an active ingredient a compound having a phosphodiesterase 10 inhibitory activity. Moreover, the present invention relates to a method for enhancing dopamine signal in the brain, which comprises administering an effective amount of a compound having a phosphodiesterase 10 inhibitory activity; and also relates to pharmaceutical composition for enhancing dopamine signal in brain comprising as an active ingredient a compound having a phosphodiesterase 10 inhibitory activity.

摘要翻译： 本发明涉及通过施用有效量的具有磷酸二酯酶10抑制活性的化合物治疗帕金森病的治疗或预防方法; 并且还涉及用于治疗或预防帕金森病的药物组合物，其包含具有磷酸二酯酶10抑制活性的化合物作为活性成分。 此外，本发明涉及一种增强脑中多巴胺信号的方法，其包括给予有效量的具有磷酸二酯酶10抑制活性的化合物; 并且还涉及用于增强脑中多巴胺信号的药物组合物，其包含具有磷酸二酯酶10抑制活性的化合物作为活性成分。

公开(公告)号：US5808065A

公开(公告)日：1998-09-15

申请号：US917113

申请日：1997-08-25

申请人： Akihiko Ishida ,  Harutami Yamada ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

发明人： Akihiko Ishida ,  Harutami Yamada ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P13/12 ,  C07D237/14 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D237/30 ,  C07D401/00 ,  C07D403/00 ,  C07D405/00

CPC分类号： C07D401/12 ,  C07D237/14 ,  C07D403/12 ,  C07D409/12

摘要： Disclosed is a pyridazinone compound represented by the formula (I): ##STR1## wherein X represents hydrogen atom or the like; Y represents a single bonding arm, oxygen atom or sulfur atom; A represents a straight or branched alkylene group which may have a double bond; B represents carbonyl group or thiocarbonyl group; and R.sup.2 represents an alkyl group having 1 to 10 carbon atoms which may be substituted or the like; or B represents sulfonyl group; and R.sup.2 represents a lower alkenyl group or the like; R.sup.1 represents hydrogen atom or the like; R.sup.3 represents hydrogen atom or the like; R.sup.4 represents hydrogen atom or the like; and R.sup.5 represents hydrogen atom or the like, or a pharmaceutically acceptable salt thereof.

摘要翻译： 公开了由式（I）表示的哒嗪酮化合物：其中X表示氢原子等;（I） Y表示单键键，氧原子或硫原子; A表示可以具有双键的直链或支链亚烷基; B表示羰基或硫代羰基; R 2表示可以具有取代基的碳原子数1〜10的烷基等。 或B表示磺酰基; 并且R 2表示低级烯基等; R1表示氢原子等; R3表示氢原子等; R4代表氢原子等; R5代表氢原子等，或其药学上可接受的盐。

公开(公告)号：US5698554A

公开(公告)日：1997-12-16

申请号：US671485

申请日：1996-06-27

申请人： Akihiko Ishida ,  Harutami Yamada ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

发明人： Akihiko Ishida ,  Harutami Yamada ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P13/12 ,  C07D237/14 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12

CPC分类号： C07D401/12 ,  C07D237/14 ,  C07D403/12 ,  C07D409/12

摘要： Disclosed is a pyridazinone compound represented by the formula (I): ##STR1## wherein X represents hydrogen atom or the like; Y represents a single bonding arm, oxygen atom or sulfur atom; A represents a straight or branched alkylene group which may have a double bond; B represents carbonyl group or thiocarbonyl group; and R.sup.2 represents an alkyl group having 1 to 10 carbon atoms which may be substituted or the like; or B represents sulfonyl group; and R.sup.2 represents a lower alkenyl group or the like; R.sup.1 represents hydrogen atom or the like; R.sup.3 represents hydrogen atom or the like; R.sup.4 represents hydrogen atom or the like; and R.sup.5 represents hydrogen atom or the like, or a pharmaceutically acceptable salt thereof.

摘要翻译： 公开了由式（I）表示的哒嗪酮化合物：其中X表示氢原子等;（I） Y表示单键键，氧原子或硫原子; A表示可以具有双键的直链或支链亚烷基; B表示羰基或硫代羰基; R 2表示可以具有取代基的碳原子数1〜10的烷基等。 或B表示磺酰基; 并且R 2表示低级烯基等; R1表示氢原子等; R3表示氢原子等; R4代表氢原子等; R5代表氢原子等，或其药学上可接受的盐。