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公开(公告)号：US08252560B2
公开(公告)日：2012-08-28
申请号：US12518285
申请日：2007-12-14
申请人： Jun Saito , Yoshitaka Senda , Keigo Hanaki , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Keigo Hanaki , Toshiteru Komatsu
CPC分类号： C12P7/6418 , C12N11/00
摘要： The present invention relates to a process for producing a fatty acid, which includes feeding a liquid mixture formed of two liquid phases that flow in a co-current manner into a fixed bed-type reaction column packed with immobilized lipase, and performing a hydrolysis reaction when the two liquid phases are in contact with the immobilized lipase in the fixed-bed reaction column; wherein the fixed-bed reaction column comprises partition plates so as to comprise a plurality of tube- shaped structures, wherein each tube-shaped structure has a cross -section which is rectangular, circular, oval, or polygonal in shape with at least a part being unclosed and the cross-section has a representative length of 100 mm or less.
摘要翻译： 本发明涉及一种脂肪酸的制造方法，其特征在于，将由以流动方式流动的两个液相形成的液体混合物输送到填充有固定化脂肪酶的固定床型反应塔中，进行水解反应 当两个液相与固定床反应塔中的固定化脂肪酶接触时; 其中所述固定床反应塔包括分隔板，以便包括多个管状结构，其中每个管状结构具有矩形，圆形，椭圆形或多边形形状的横截面，至少部分 未封闭，横截面长度为100mm以下。
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公开(公告)号：US08173403B2
公开(公告)日：2012-05-08
申请号：US12517574
申请日：2007-12-14
申请人： Yoshitaka Senda , Jun Saito , Keigo Hanaki , Toshiteru Komatsu
发明人： Yoshitaka Senda , Jun Saito , Keigo Hanaki , Toshiteru Komatsu
摘要： The present invention relates to a process for producing a useful substance, the process includes feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, and allowing the liquid mixture to flow in the same direction in a co-current manner to perform a reaction. The packing thickness of the immobilized enzyme per stage of the fixed bed-type reaction column having an equivalent circular diameter of 35 mmφ or larger is 10 to 200 mm. The flow of the reaction liquid inside the column can be made uniform, and as a result, reactivity and productivity is enhanced.
摘要翻译： 本发明涉及一种生产有用物质的方法，该方法包括将由两个液相形成的液体混合物进料到装有固定化酶的固定床型反应塔中，并使液体混合物沿相同方向流动 以同时的方式进行反应。 固定床型反应塔每个阶段的固定化酶的包装厚度为等效圆直径为35mm＆phgr; 以上为10〜200mm。 可以使柱内的反应液的流动均匀，结果提高了反应性和生产率。
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公开(公告)号：US20100047883A1
公开(公告)日：2010-02-25
申请号：US12517574
申请日：2007-12-14
申请人： Yoshitaka Senda , Jun Saito , Keigo Hanaki , Toshiteru Komatsu
发明人： Yoshitaka Senda , Jun Saito , Keigo Hanaki , Toshiteru Komatsu
摘要： The present invention relates to a process for producing a useful substance, the process including feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, and allowing the liquid mixture to flow in the same direction in a co-current manner to perform a reaction, wherein the packing thickness of the immobilized enzyme per stage of the fixed bed-type reaction column having an equivalent circular diameter of 35 mmφ or larger is 10 to 200 mm.In the process for producing a useful substance, which is performed by feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, the flow of the reaction liquid inside the column can be made uniform, and as a result, reactivity and productivity can be enhanced.
摘要翻译： 本发明涉及一种生产有用物质的方法，该方法包括将由两个液相形成的液体混合物进料到装有固定化酶的固定床型反应塔中，并使液体混合物沿相同方向流动 以同时的方式进行反应，其中每个固定床型反应塔的固定化酶的包装厚度具有等效的圆直径为35mm＆phgr; 以上为10〜200mm。 在通过将由两个液相形成的液体混合物进料到填充有固定化酶的固定床型反应塔中进行的有用物质的制造方法中，能够使柱内的反应液的流动均匀， 结果可以提高反应性和生产率。
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公开(公告)号：US20100041114A1
公开(公告)日：2010-02-18
申请号：US12518285
申请日：2007-12-14
申请人： Jun Saito , Yoshitaka Senda , Keigo Hanaki , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Keigo Hanaki , Toshiteru Komatsu
IPC分类号： C12P7/64
CPC分类号： C12P7/6418 , C12N11/00
摘要： The present invention relates to a process for producing a useful substance, which includes feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, and performing a reaction while allowing the liquid mixture to flow in the same direction in a co-current manner, wherein the fixed bed-type reaction column has partition plates inserted in the longitudinal direction of the fixed bed-type reaction column so as to form a plurality of tube-shaped structures, wherein each tube-shaped structure has a lateral cross-section which is circular or polygonal in shape with at least a part being unclosed and has a representative length of 100 mm or less, wherein the immobilized enzyme is packed into the tube-shaped structures, and wherein the liquid mixture is fed into the tube-shaped structures.Even when a reaction column having a large column diameter is used in the reaction performed by feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, the flow of the whole reaction liquid inside the column can be made uniform, and the enzymatic activity can be effectively appeared. As a result, reactivity and productivity can be enhanced. Particularly, in the hydrolysis of oils and fats, the enzymatic activity can be effectively appeared, so that fatty acids can be effectively produced. Furthermore, the operability at the time of removing the immobilized enzyme packed in the reaction column is good.
摘要翻译： 本发明涉及一种生产有用物质的方法，包括将由两个液相形成的液体混合物进料到装有固定化酶的固定床型反应塔中，并进行反应同时使液体混合物流入 相同的方向，其中固定床型反应塔具有沿固定床型反应塔的纵向方向插入的隔板，以形成多个管状结构， 所述圆形结构具有圆形或多边形的横截面，其至少一部分未封闭并且具有100mm或更小的代表性长度，其中所述固定化酶被包装在所述管状结构体中，并且其中所述液体 混合物被送入管状结构。 即使在通过将由两个液相形成的液体混合物进料到装有固定化酶的固定床型反应塔中进行的反应中使用具有大柱直径的反应塔时，柱内的整个反应液体的流动 可以均匀，可以有效地出现酶活性。 因此，可以提高反应性和生产率。 特别是在油脂的水解中，能够有效地发挥酶活性，能够有效地制造脂肪酸。 此外，除去反应塔中填充的固定化酶时的操作性良好。
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5.发明授权公开(公告)号：US08241875B2
公开(公告)日：2012-08-14
申请号：US11450356
申请日：2006-06-12
申请人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
CPC分类号： C11C1/045 , C12P7/6418
摘要： A process for producing fatty acids, which comprises supplying an oil phase substrate and a water phase substrate to an enzyme column packed with an immobilized enzyme, concurrently flowing them in the same direction, and hydrolyzing a fat and/or oil, wherein the oil phase substrate and the water phase substrate are alternately supplied to the enzyme column.
摘要翻译： 一种生产脂肪酸的方法，其包括将油相底物和水相底物供给到装有固定化酶的酶柱，同时沿相同方向流动，并水解脂肪和/或油，其中所述油相 底物和水相底物交替供应到酶柱。
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6.发明申请公开(公告)号：US20090298142A1
公开(公告)日：2009-12-03
申请号：US12067664
申请日：2006-10-04
申请人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
CPC分类号： C12N9/20 , C12N11/00 , C12P7/6418
摘要： The present invention provides a method for producing a useful substance by supplying, to a fixed-bed reactor packed with an immobilized enzyme, a liquid mixture containing two liquid phases, in which the two liquid phases are allowed to flow in an identical, parallel direction, which method employs a fixed-bed reactor equipped with an insertion unit or tubes, so as to form a plurality of lumens in the fixed-bed reactor, each lumen having a cross section of a circular shape with a diameter of 100 mm or less or having a polygonal shape with a diagonal line of 100 mm or less, wherein the lumens are packed with an immobilized enzyme and the liquid mixture is supplied therethrough. In a reaction performed by passing a reaction mixture exhibiting two liquid phases through a fixed-bed reactor equipped with an immobilized enzyme, overall flow of the reaction liquid is made uniform, to thereby facilitate production of a useful substance in an efficient manner.
摘要翻译： 本发明提供一种制造有用物质的方法，该方法通过向固定化酶反应器中填充固定化酶，提供含有两个液相的液体混合物，其中允许两个液相沿相同的平行方向流动 该方法采用装备有插入单元或固定床的固定床反应器，以在固定床反应器中形成多个内腔，每个管腔具有直径为100mm以下的圆形截面 或具有对角线为100mm或更小的多边形形状，其中，腔内填充有固定化酶，并且通过其提供液体混合物。 在通过使具有两个液相的反应混合物通过装有固定化酶的固定床反应器进行的反应中，使反应液体的整体流动均匀，从而有效地制备有用物质。
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公开(公告)号：US20060292675A1
公开(公告)日：2006-12-28
申请号：US11450356
申请日：2006-06-12
申请人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
IPC分类号： C12P7/64
CPC分类号： C11C1/045 , C12P7/6418
摘要： A process for producing fatty acids, which comprises supplying an oil phase substrate and a water phase substrate to an enzyme column packed with an immobilized enzyme, concurrently flowing them in the same direction, and hydrolyzing a fat and/or oil, wherein the oil phase substrate and the water phase substrate are alternately supplied to the enzyme column.
摘要翻译： 一种生产脂肪酸的方法，其包括将油相底物和水相底物供给到装有固定化酶的酶柱，同时沿相同方向流动，并水解脂肪和/或油，其中所述油相 底物和水相底物交替供应到酶柱。
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8.发明授权公开(公告)号：US08377664B2
公开(公告)日：2013-02-19
申请号：US12067664
申请日：2006-10-04
申请人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
CPC分类号： C12N9/20 , C12N11/00 , C12P7/6418
摘要： The present invention provides a method for producing a useful substance by supplying, to a fixed-bed reactor packed with an immobilized enzyme, a liquid mixture containing two liquid phases, in which the two liquid phases are allowed to flow in an identical, parallel direction, which method employs a fixed-bed reactor equipped with an insertion unit or tubes, so as to form a plurality of lumens in the fixed-bed reactor, each lumen having a cross section of a circular shape with a diameter of 100 mm or less or having a polygonal shape with a diagonal line of 100 mm or less, wherein the lumens are packed with an immobilized enzyme and the liquid mixture is supplied. In a reaction performed by passing a reaction mixture exhibiting two liquid phases through a fixed-bed reactor equipped with an immobilized enzyme, overall flow of the reaction liquid is made uniform.
摘要翻译： 本发明提供一种制造有用物质的方法，该方法通过向固定化酶反应器中填充固定化酶，提供含有两个液相的液体混合物，其中允许两个液相沿相同的平行方向流动 该方法采用装备有插入单元或固定床的固定床反应器，以在固定床反应器中形成多个内腔，每个内腔具有直径为100mm或更小的圆形截面 或具有对角线为100mm或更小的多边形形状，其中，腔内填充固定化酶并提供液体混合物。 在通过使具有两个液相的反应混合物通过装有固定化酶的固定床反应器进行的反应中，使反应液体的整体流动均匀。
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公开(公告)号：US20140231866A1
公开(公告)日：2014-08-21
申请号：US14347897
申请日：2011-09-28
申请人： Masaru Senoo , Kyosuke Miyagi , Tsuyoshi Nishiwaki , Jun Saito
发明人： Masaru Senoo , Kyosuke Miyagi , Tsuyoshi Nishiwaki , Jun Saito
IPC分类号： H01L29/739 , H01L29/66
CPC分类号： H01L29/66348 , H01L29/0696 , H01L29/0834 , H01L29/1095 , H01L29/36 , H01L29/6634 , H01L29/7396 , H01L29/7397
摘要： An IGBT has an emitter region, a top body region that is formed below the emitter region, a floating region that is formed below the top body region, a bottom body region that is formed below the floating region, a trench, a gate insulating film that covers an inner face of the trench, and a gate electrode that is arranged inside the trench. When a distribution of a concentration of p-type impurities in the top body region and the floating region, which are located below the emitter region, is viewed along a thickness direction of a semiconductor substrate, the concentration of the p-type impurities decreases as a downward distance increases from an upper end of the top body region that is located below the emitter region, and assumes a local minimum value at a predetermined depth in the floating region.
摘要翻译： IGBT具有发射极区域，形成在发射极区域下方的顶部主体区域，形成在顶部主体区域下方的浮动区域，形成在浮动区域下方的底部区域，沟槽，栅极绝缘膜 覆盖沟槽的内表面和布置在沟槽内的栅电极。 当沿着半导体衬底的厚度方向观察位于发射极区域下方的顶体区域和浮动区域中的p型杂质浓度的分布时，p型杂质的浓度随着 向下的距离从位于发射极区域下方的顶部主体区域的上端增加，并且在浮动区域中在预定深度处呈现局部最小值。
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公开(公告)号：US08794606B2
公开(公告)日：2014-08-05
申请号：US12673689
申请日：2008-08-26
申请人： Nobuo Kubo , Hiroshi Yanagase , Jun Saito , Masatomo Nishizaka
发明人： Nobuo Kubo , Hiroshi Yanagase , Jun Saito , Masatomo Nishizaka
IPC分类号： F16F5/00
CPC分类号： F16F13/106
摘要： A liquid sealed vibration isolating device has an elastically movable diaphragm capable of preventing elastic deformation of a relief valve to realize high damping while preventing a cavitation phenomenon. The relief valve is provided in the elastic movable diaphragm arranged in a partition member in order to open and close a leak passage so as to prevent occurrence of the cavitation phenomenon. The relief valve is integrally formed with a fixing portion of the elastic movable diaphragm. There is provided an upwardly open concavity that the relief valve faces. The relief valve is made thicker and provided with an opening and closing adjustment groove at a basal portion of its inclined wall. The opening and closing adjustment groove is formed with a locally thin bending portion functioning as a starting point of bending in an opening and closing operation of the relief valve.
摘要翻译： 液体密封隔振装置具有能够防止安全阀的弹性变形以防止气蚀现象而实现高阻尼的弹性移动隔膜。 安全阀设置在布置在分隔构件中的弹性可动隔膜中，以便打开和关闭泄漏通道，以防止发生气蚀现象。 安全阀与弹性活动隔膜的固定部分整体形成。 提供了安全阀面对的向上开口的凹陷。 安全阀制成较厚，并在其倾斜壁的基部设置有开闭调节槽。 开关调节槽形成有局部薄的弯曲部，其作为安全阀的打开和关闭操作中的弯曲起点。
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