公开(公告)号：US20080165984A1

公开(公告)日：2008-07-10

申请号：US11948232

申请日：2007-11-30

申请人： Jung A. Yun ,  Hyoung Tae Kim ,  Baekdoosan Lee

发明人： Jung A. Yun ,  Hyoung Tae Kim ,  Baekdoosan Lee

IPC分类号： H04B1/00 ,  H04B1/034 ,  H04B7/00

CPC分类号： H04M1/6091 ,  H04M2250/02

摘要： An audio output system and method for an information processing terminal having an internal speaker system are provided for selectively outputting audio signal through an external speaker system. An audio output method for an information processing device includes generating an audio signal in an operation mode; checking an output module of the audio signal; outputting, if the output module is an internal speaker, the audio signal through the internal speaker; tuning, if the output module is a transmitter, the transmitter to a reception frequency of the external speaker system; and transmitting the audio signal to the external speaker system through the transmission frequency via the transmitter.

摘要翻译： 提供一种具有内部扬声器系统的信息处理终端的音频输出系统和方法，用于通过外部扬声器系统选择性地输出音频信号。 一种用于信息处理设备的音频输出方法包括在操作模式中产生音频信号; 检查音频信号的输出模块; 如果输出模块是内部扬声器，则通过内部扬声器输出音频信号; 调谐，如果输出模块是发射机，发射机到外部扬声器系统的接收频率; 并通过发射机通过传输频率将音频信号发送到外部扬声器系统。

公开(公告)号：US20100056456A1

公开(公告)日：2010-03-04

申请号：US12513182

申请日：2007-11-02

申请人： Jae Il Kim ,  Hye Whon Rhim ,  Hyun Jeong Kim ,  Hong Won Suh ,  Soung Hun Roh ,  Jung A. Yun ,  Seung Kyu Lee ,  Young Jae Eu ,  Heung Sik Na

发明人： Jae Il Kim ,  Hye Whon Rhim ,  Hyun Jeong Kim ,  Hong Won Suh ,  Soung Hun Roh ,  Jung A. Yun ,  Seung Kyu Lee ,  Young Jae Eu ,  Heung Sik Na

IPC分类号： A61K38/10 ,  C07K7/08 ,  C07H21/00 ,  A61P25/00

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： The present invention relates to a method for increasing the binding reversibility of a ω-conotoxin to a N-type calcium channel, which comprises preparing a ω-conotoxin having a Ile and/or Ala residue at a position of amino acid (11 and/or 12), respectively in the second loop between cysteine residues (2 and 3) of the ω-conotoxin represented by the formula I, such that the prepared ω-conotoxin has the increased binding reversibility to N-type calcium channel. In addition, the present invention relates to a novel ω-conotoxin and a pharmaceutical composition having plausible properties in view of blocking activity to and specificity to N-type calcium channel, and dramatically improved binding reversibility to N-type calcium channel.

摘要翻译： 本发明涉及一种增加ω-芋螺毒素与N-型钙通道的结合可逆性的方法，其包括在氨基酸（11和/或其氨基酸）的位置制备具有Ile和/或Ala残基的ω-芋螺毒素， 或12）分别在由式I表示的ω-芋螺毒素的半胱氨酸残基（2和3）之间的第二环中，使得制备的ω-芋螺毒素对N-型钙通道具有增加的结合可逆性。 此外，本发明涉及一种新型的ω-芋螺毒素和具有似乎合理的性质的药物组合物，其特征在于阻断N-型钙通道的活性和特异性，并显着提高了与N-型钙通道的结合可逆性。