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    [1,2,4] triazolo [1,5-C] pyrimidine derivatives
    2.
    发明授权
    [1,2,4] triazolo [1,5-C] pyrimidine derivatives 失效
    [1,2,4]三唑并[1,5-C]嘧啶衍生物

    公开(公告)号：US06222035B1

    公开(公告)日：2001-04-24

    申请号：US09401984

    申请日：1999-09-23

    申请人： Hiroshi Tsumuki ,  Junichi Shimada ,  Hironori Imma ,  Akiko Nakamura ,  Hiromi Nonaka ,  Shizuo Shiozaki ,  Shunji Ichikawa ,  Tomoyuki Kanda ,  Yoshihisa Kuwana ,  Michio Ichimura ,  Fumio Suzuki

    发明人： Hiroshi Tsumuki ,  Junichi Shimada ,  Hironori Imma ,  Akiko Nakamura ,  Hiromi Nonaka ,  Shizuo Shiozaki ,  Shunji Ichikawa ,  Tomoyuki Kanda ,  Yoshihisa Kuwana ,  Michio Ichimura ,  Fumio Suzuki

    IPC分类号： C07D48700

    CPC分类号： C07D487/04

    摘要： [1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof are provided, which have adenosine A2A receptor antagonism and are useful for the treatment or prevention of various diseases induced by hyperactivity of adenosine A2A receptors (for example, Parkinson's disease or senile dementia): wherein R1 represents substituted or unsubstituted aryl, or the like; R2 represents hydrogen, halogen, lower alkyl, substituted or unsubstituted aryl, or the like; R3 represents hydrogen, halogen, XR10 (wherein X represents O or S; and R10 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic ring, substituted or unsubstituted aralkyl, lower alkyl, or hydroxy lower alkyl), or the like; and Q represents hydrogen or 3,4-dimethoxybenzyl.

    摘要翻译： [1,2,4]具有式（I）表示的三唑并[1,5-c]嘧啶衍生物或其药学上可接受的盐，其具有腺苷A2A受体拮抗作用，可用于治疗或预防由 腺苷A2A受体（例如帕金森病或老年性痴呆）的多动症：其中R1表示取代或未取代的芳基等; R 2表示氢，卤素，低级烷基，取代或未取代的芳基等; R3表示氢，卤素，XR10（其中X表示O或S; R10表示取代或未取代的芳基，取代或未取代的芳族杂环，取代或未取代的芳烷基，低级烷基或羟基低级烷基）等; Q表示氢或3,4-二甲氧基苄基。

    Antiepileptic agent
    3.
    发明申请
    Antiepileptic agent 审中-公开
    抗癫痫剂

    公开(公告)号：US20060122198A1

    公开(公告)日：2006-06-08

    申请号：US10560598

    申请日：2004-06-25

    申请人： Shunji Ichikawa ,  Chiemi Takashima ,  Hironori Imma ,  Junichi Shimada

    发明人： Shunji Ichikawa ,  Chiemi Takashima ,  Hironori Imma ,  Junichi Shimada

    IPC分类号： A61K31/522

    CPC分类号： A61K31/522 ,  C07D473/12

    摘要： An antiepileptic agent which contains either a xanthine derivative represented by the formula (I): (I) (wherein R1, R2, and R3 are the same or different and each represents hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; R4 represents cycloalkyl, —(CH2)n.R5, or the formula (II); (II) and X1 and X2 are the same or different and each represents oxygen or sulfur) or a pharmacologically acceptable salt thereof as an active ingredient.

    摘要翻译： 含有由式（I）表示的黄嘌呤衍生物：（I）（其中R 1，R 2，R 2和R 3）的抗癫痫剂， SUP>相同或不同，各自表示氢，低级烷基，低级烯基或低级炔基; R 4表示环烷基， - （CH 2）n 或者式（II）;（II）和X 1和X 2相同或不同 并且各自表示氧或硫）或其药理学上可接受的盐作为活性成分。