公开(公告)号：US11952408B2

公开(公告)日：2024-04-09

申请号：US16652379

申请日：2018-09-28

申请人： Juno Therapeutics, Inc. ,  Editas Medicine, Inc.

发明人： Cameron Brandt ,  Brian Belmont ,  Christopher Borges ,  Stephen Michael Burleigh ,  Alexandra Croft ,  Stephen Jacob Goldfless ,  David Jeffrey Huss ,  Yue Jiang ,  Timothy G. Johnstone ,  David Koppstein ,  Hieu Nguyen ,  Christopher Heath Nye ,  Haley Peper ,  Blythe D. Sather ,  Sonia Timberlake ,  Dean Y. Toy ,  Queenie Vong ,  Gordon Grant Welstead ,  James Sissons

IPC分类号： C07K14/705 ,  A61K35/17 ,  A61P31/20 ,  A61P35/00 ,  C07K14/725 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC分类号： C07K14/7051 ,  A61K35/17 ,  A61P31/20 ,  A61P35/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/80

摘要： Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.