公开(公告)号：US11952408B2

公开(公告)日：2024-04-09

申请号：US16652379

申请日：2018-09-28

申请人： Juno Therapeutics, Inc. ,  Editas Medicine, Inc.

发明人： Cameron Brandt ,  Brian Belmont ,  Christopher Borges ,  Stephen Michael Burleigh ,  Alexandra Croft ,  Stephen Jacob Goldfless ,  David Jeffrey Huss ,  Yue Jiang ,  Timothy G. Johnstone ,  David Koppstein ,  Hieu Nguyen ,  Christopher Heath Nye ,  Haley Peper ,  Blythe D. Sather ,  Sonia Timberlake ,  Dean Y. Toy ,  Queenie Vong ,  Gordon Grant Welstead ,  James Sissons

IPC分类号： C07K14/705 ,  A61K35/17 ,  A61P31/20 ,  A61P35/00 ,  C07K14/725 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC分类号： C07K14/7051 ,  A61K35/17 ,  A61P31/20 ,  A61P35/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/80

摘要： Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

公开(公告)号：US20230002760A1

公开(公告)日：2023-01-05

申请号：US17572403

申请日：2022-01-10

申请人： Editas Medicine, Inc.

发明人： Gordon Grant Welstead ,  Jennifer Leah Gori ,  Jack Michael Heath ,  David A. Bumcrot

IPC分类号： C12N15/11 ,  C12N15/113 ,  A61P7/00 ,  A61K35/17 ,  C12N5/0783 ,  C12N9/22 ,  C12N9/96

摘要： CRISPR/Cas-related compositions and methods which provide for efficient gene editing of eukaryotic cells using modified gRNAs.

公开(公告)号：US20220143084A1

公开(公告)日：2022-05-12

申请号：US17430382

申请日：2020-02-14

申请人： Editas Medicine, Inc.

发明人： Gordon Grant Welstead ,  Christopher Borges ,  Karrie Ka Wai Wong

IPC分类号： A61K35/17 ,  C12N5/0783 ,  C12N15/113 ,  C12N9/22 ,  A61P35/00

摘要： The present disclosure is directed to the generation of NK cells (or other lymphocytes) from induced pluripotent cells that have been derived from cells, e.g., developmentally mature T cells, and uses thereof for immunotherapy.

公开(公告)号：US20190062735A1

公开(公告)日：2019-02-28

申请号：US16121152

申请日：2018-09-04

申请人： EDITAS MEDICINE, INC.

发明人： Gordon Grant Welstead ,  Hariharan Jayaram ,  Tongyao Wang ,  John Anthony Zuris ,  Christopher Borges

IPC分类号： C12N15/11 ,  C12N9/22 ,  C12N15/90 ,  A61K35/17

摘要： CRISPR/Cpf1-related compositions and methods for treatment of cancer.

公开(公告)号：US20180112213A1

公开(公告)日：2018-04-26

申请号：US15560968

申请日：2016-03-25

申请人： Editas Medicine, Inc.

发明人： Gordon Grant Welstead ,  Jennifer Leah Gori ,  Jack Michael Heath ,  David A. Bumcrot

IPC分类号： C12N15/11 ,  C12N9/22 ,  C12N9/96 ,  C12N5/0783 ,  A61K35/17 ,  A61P7/00

CPC分类号： C12N15/11 ,  A61K35/17 ,  A61K48/00 ,  A61P7/00 ,  C12N5/0636 ,  C12N9/22 ,  C12N9/96 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/20 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/318 ,  C12N2310/3231 ,  C12N2310/3235 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/336 ,  C12N2310/344 ,  C12N2320/51

摘要： CRISPR/Cas-related compositions and methods which provide for efficient gene editing of eukaryotic cells using modified gRNAs.