利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

53 条记录 (耗时 0.024 秒)

    4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof
    6.
    发明授权
    4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof 有权
    4-取代的奎宁环衍生物，生产方法，药物用途

    公开(公告)号：US08114891B2

    公开(公告)日：2012-02-14

    申请号：US12242389

    申请日：2008-09-30

    申请人： Jürg R. Pfister ,  Meenakshi S. Venkatraman ,  Xiaoming Zhang

    发明人： Jürg R. Pfister ,  Meenakshi S. Venkatraman ,  Xiaoming Zhang

    IPC分类号： A61K31/439 ,  C07D401/12

    CPC分类号： C07D453/02 ,  C07D471/08

    摘要： The present invention relates to compounds and formulations capable of affecting nicotinic acetylcholine receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the alpha7 nAChR subtype). The present invention also relates to methods for treating a wide variety of conditions and disorders, particularly those associated with dysfunction of the central and autonomic nervous systems.

    摘要翻译： 本发明涉及能够影响烟碱乙酰胆碱受体（nAChR）的化合物和制剂，例如作为特异性烟碱受体亚型（特别是α7nAChR亚型）的调节剂。 本发明还涉及用于治疗各种各样的病症和疾病的方法，特别是与中枢神经系统和自主神经系统的功能障碍有关的方法。

    Materials and Methods for Treating Coagulation Disorders
    10.
    发明申请
    Materials and Methods for Treating Coagulation Disorders 审中-公开
    治疗凝血障碍的材料和方法

    公开(公告)号：US20080221204A1

    公开(公告)日：2008-09-11

    申请号：US12125623

    申请日：2008-05-22

    申请人： Pascal Druzgala ,  Xiaoming Zhang ,  Jurg R. Pfister

    发明人： Pascal Druzgala ,  Xiaoming Zhang ,  Jurg R. Pfister

    IPC分类号： A61K31/352 ,  A61P7/02

    CPC分类号： A61K31/37 ,  A61K31/366 ,  C07D311/56

    摘要： This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

    摘要翻译： 本发明涉及更容易被代谢药物解毒系统代谢的化合物。 特别地，教导了被设计成在化合物的结构内包含酯的华法林类似物。 本发明教导了在药物合成期间降低包括将酯基引入药物的药物的毒性的方法。 本发明还涉及治疗凝血障碍的方法，其包括施用被设计为由血清或细胞内水解酶和酯酶代谢的化合物。 还教导了含有华法林酯类药物组合物。