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    Process for the preparation of pyrrolo[3,4-c]pyrroles
    4.
    发明授权
    Process for the preparation of pyrrolo[3,4-c]pyrroles 失效
    制备吡咯并[3,4-c]吡咯的方法

    公开(公告)号：US4931566A

    公开(公告)日：1990-06-05

    申请号：US218770

    申请日：1988-07-14

    申请人： Werner Surber ,  Abul Iqbal ,  Christian Stern

    发明人： Werner Surber ,  Abul Iqbal ,  Christian Stern

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： Process for the preparation of 1,4-diketopyrrolo[3,4-c]pyrroles of the formula I ##STR1## in which R.sub.1 and R.sub.2 independently of one another are phenyl, biphenyl or naphthyl radicals or aromatic O-heterocyclic, S-heterocyclic or N-heterocyclic radicals, by reacting 1 mole of a dicyclohexyl succinate, dialkyl succinate, monoalkylmonophenyl or diphenyl succinate, alkyl in the succinic acid ester radical being C.sub.1 -C.sub.18 alkyl and phenyl being phenyl which is unsubstituted or substituted by one or two halogen atoms or one or two C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy groups, with 2 moles of a nitrile of the formula II or III or with 1 mole of a nitrile of the formula II and 1 mole of a nitrile of the formula III ##STR2## in which R.sub.1 and R.sub.2 are as defined above, in an inert organic solvent, in the presence of an alkali metal or an alkali metal alcoholate, as a strong base, and at an elevated temperature to give an alkali metal salt of the formula IV ##STR3## in which M is an alkali metal, and subsequently liberating a compound of the formula I by protolysis of a compound of the above formula IV, which comprises treating, in stages, a compound of the above formula IV in at least two portions, as a protolysing agent, with water, with an inorganic and/or organic acid, with a mixture of water and an organic solvent, or with a mixture of an inorganic or organic acid and water and/or at least one organic solvent, and reacting the mixture at a temperature from 20.degree. to 150.degree. C. after the addition of each of the portions.

    摘要翻译： 制备式I的1,4-二酮吡咯并[3,4-c]吡咯的方法其中R 1和R 2彼此独立地为苯基，联苯基或萘基或芳族O-杂环， 通过使1摩尔琥珀酸二环己酯，琥珀酸二烷基酯，单烷基单苯基或二苯基琥珀酸酯反应，琥珀酸酯基中的烷基为C 1 -C 18烷基，苯基为未取代或被一个或两个取代的苯基， 卤素原子或一个或两个C 1 -C 6烷基或C 1 -C 6烷氧基，与2摩尔式II或III的腈或1摩尔式II的腈和1摩尔式III的腈R1- CN，（II）其中R 1和R 2如上定义的R 2 -CN（III）在惰性有机溶剂中，在碱金属或碱金属醇盐存在下，作为强碱，并在高温下 得到式IV其中M是碱金属的式IV的碱金属盐， 然后通过将上述式Ⅳ化合物原体解分解出式Ⅰ化合物，该化合物包括分阶段将上述式Ⅳ化合物在至少两份中作为原溶剂与水一起分别处理 无机和/或有机酸，与水和有机溶剂的混合物，或与无机或有机酸和水和/或至少一种有机溶剂的混合物，并在20℃至150℃的温度下使混合物反应 加入各部分之后。