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1.发明授权Cyclic peptides as promoters of absorption on administration onto the mucosa 失效作为吸收在MUCOSA上的吸收促进剂的循环肽
公开(公告)号：US5091365A
公开(公告)日：1992-02-25
申请号：US228651
申请日：1988-08-05
CPC分类号： A61K47/42
摘要： The invention relates to the use of aids of the general formula ##STR1## in which B denotes a basic amino acid, A/B denotes an acidic or basic amino acid, X denotes a neutral and hydrophilic amino acid, L denotes a lipophilic neutral amino acid, and R denotes hydrogen or an acyl radical, or the physiologically tolerated salts thereof, for promoting the absorption of peptides and proteins on administration onto the mocosa, as well as to pharmaceutical compositions which contain a pharmacologically effective amount of one or more peptides or proteins as well as an aid of the abovementioned formula.
摘要翻译： 本发明涉及使用通式“IMAGE”的助剂，其中B表示碱性氨基酸，A / B表示酸性或碱性氨基酸，X表示中性和亲水性氨基酸，L表示亲脂性中性氨基 酸，R表示氢或酰基，或其生理上耐受的盐，用于促进肽和蛋白质在施用于马卡土上时的吸收，以及含有药理学有效量的一种或多种肽的药物组合物或 蛋白质以及上述配方的辅助。
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2.发明授权Active ingredient patch for low-melting and/or volatile active ingredients 失效用于低熔点和/或挥发性活性成分的活性成分贴剂
公开(公告)号：US5527536A
公开(公告)日：1996-06-18
申请号：US367262
申请日：1995-02-27
CPC分类号： A61K9/7053 , A61K9/7076 , A61L15/58
摘要： The invention concerns a patch for the controlled release of readily available volatile active substances to the skin, the patch comprising a back layer and, bonded to it, a water-insoluble adhesive film consisting of a pressure-sensitive fusion adhesive, plus a detachable film covering the adhesive film. The patch is characterized in that the pressure-sensitive fusion adhesive contains a triple-block copolymer of polystyrene block copoly(ethylene/butylene) block polystyrene (SEBS) at a concentration of 10 to 80% by wt., and an active substance which, at the temperature at which the adhesive bonds, is a readily volatile liquid, and which is present at a concentration of 2.5 to 25% by wt.
摘要翻译： PCT No.PCT / DE93 / 00638 Sec。 371日期：1995年2月27日 102（e）日期1995年2月27日PCT提交1993年7月17日PCT公布。 公开号WO94 / 02123 日期1994年2月3日。本发明涉及一种用于将容易获得的挥发性活性物质控制释放到皮肤上的贴剂，该贴剂包含背层并与其结合，由不溶于水的粘合剂组成的水不溶性粘合剂膜 熔融粘合剂，以及覆盖粘合剂膜的可拆卸膜。 该贴剂的特征在于，压敏熔融粘合剂含有浓度为10〜80重量％的聚苯乙烯嵌段共聚（乙烯/丁烯）嵌段聚苯乙烯（SEBS）的三嵌段共聚物和活性物质， 在粘合剂粘合的温度下，是易挥发的液体，其浓度为2.5至25重量％。
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3.发明授权Active ingredient patch for low-melting and/or volatile active ingredients 失效用于低熔点和/或挥发性活性成分的活性成分贴剂
公开(公告)号：US5603948A
公开(公告)日：1997-02-18
申请号：US483312
申请日：1995-06-07
CPC分类号： A61K9/7053 , A61K9/7076 , A61L15/58
摘要： A method of preparing a patch for the controlled release of readily available volatile active substances to the skin is disclosed. The patch comprises a back layer, and, bonded to the back layer, a water-insoluble adhesive film consisting of a pressure-sensitive fusion adhesive, plus a detachable film covering the adhesive film. The pressure-sensitive fusion adhesive contains a triple-block copolymer of polystyrene block copoly(ethylene/butylene) block polystyrene at a concentration of 10 to 80% by wt., and an active substance at a concentration of 2.5 to 25% by weight, which is a readily volatile liquid at the temperature at which the adhesive bonds.
摘要翻译： 公开了一种制备用于将容易获得的挥发性活性物质控制释放到皮肤上的贴剂的方法。 贴片包括背层，并且与背层结合由压敏熔融粘合剂组成的水不溶性粘合剂膜，以及覆盖粘合剂膜的可拆卸膜。 压敏熔融粘合剂含有浓度为10〜80重量％的聚苯乙烯嵌段共聚（乙烯/丁烯）嵌段聚苯乙烯和浓度为2.5〜25重量％的活性物质的三嵌段共聚物， 其在粘合剂粘合的温度下是易挥发的液体。
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