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公开(公告)号：US10294261B2
公开(公告)日：2019-05-21
申请号：US14424826
申请日：2013-09-03
IPC分类号： C07H19/06 , C07H21/04 , C09B23/04 , C09B23/06 , C07H19/073 , C12Q1/6876
摘要： The present invention provides a compound represented by the following chemical formula (I); a tautomer or stereoisomer of the compound; or a salt of the compound, the tautomer, or the stereoisomer. In the chemical formula (I), R1 and R2 are each a Group 1 element or a protecting group of an amino group and may be identical to or different from each other, or alternatively, R1 and R2 together may form a protecting group of an amino group. R3 is a Group 1 element or a protecting group of a hydroxy group. R4 is a Group 1 element or —PR5R6R7R8 (R5, R6, R7, and R8 are each a Group 1 element, a lone electron pair, a Group 16 element, a Group 17 element, or a protecting group of a phosphorus atom, and may be identical to or different from each other). J is a hydrogen atom or an arbitrary atomic group, A is a hydrogen atom, a hydroxy group, an alkyl group, an aralkyl group, an alkoxy group, an electron-withdrawing group, a silylene group, or a sulfide group, or alternatively, J and A together may form a linker. L is a single bond or a linker (a linking atom or a linking atomic group), the main chain length (the number of main chain atoms) of the linker is arbitrary, L may or may not contain each of C, N, O, S, P, and Si in the main chain, and may or may not contain each of a single bond, a double bond, a triple bond, an amide bond, an ester bond, a disulfide bond, an imino group, an ether bond, a thioether bond, and a thioester bond in the main chain. Z is an atomic group that can form a peptide bond with a labeling compound, or is an atom or atomic group including a label.
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公开(公告)号：US20150252070A1
公开(公告)日：2015-09-10
申请号：US14424826
申请日：2013-09-03
CPC分类号： C07H19/06 , C07H19/073 , C07H21/04 , C09B23/04 , C09B23/06 , C12Q1/6876 , Y02P20/55
摘要： The present invention provides a compound represented by the following chemical formula (I); a tautomer or stereoisomer of the compound; or a salt of the compound, the tautomer, or the stereoisomer. In the chemical formula (I), R1 and R2 are each a Group 1 element or a protecting group of an amino group and may be identical to or different from each other, or alternatively, R1 and R2 together may form a protecting group of an amino group. R3 is a Group 1 element or a protecting group of a hydroxy group. R4 is a Group 1 element or —PR5R6R7R8 (R5, R6, R7, and R8 are each a Group 1 element, a lone electron pair, a Group 16 element, a Group 17 element, or a protecting group of a phosphorus atom, and may be identical to or different from each other). J is a hydrogen atom or an arbitrary atomic group, A is a hydrogen atom, a hydroxy group, an alkyl group, an aralkyl group, an alkoxy group, an electron-withdrawing group, a silylene group, or a sulfide group, or alternatively, J and A together may form a linker. L is a single bond or a linker (a linking atom or a linking atomic group), the main chain length (the number of main chain atoms) of the linker is arbitrary, L may or may not contain each of C, N, O, S, P, and Si in the main chain, and may or may not contain each of a single bond, a double bond, a triple bond, an amide bond, an ester bond, a disulfide bond, an imino group, an ether bond, a thioether bond, and a thioester bond in the main chain. Z is an atomic group that can form a peptide bond with a labeling compound, or is an atom or atomic group including a label.
摘要翻译： 本发明提供由下列化学式（I）表示的化合物。 化合物的互变异构体或立体异构体; 或化合物的盐，互变异构体或立体异构体。 在化学式（I）中，R 1和R 2各自为1族元素或氨基的保护基，并且可以相同或不同，或者，R 1和R 2可以一起形成保护基 氨基。 R3是第1族元素或羟基的保护基。 R4是第1族元素或-PR5R6R7R8（R5，R6，R7和R8分别是第1族元素，单电子对，第16族元素，第17族元素或磷原子的保护基， 可以彼此相同或不同）。 J为氢原子或任意的原子团，A为氢原子，羟基，烷基，芳烷基，烷氧基，吸电子基，亚甲硅烷基或硫醚基，或者 J和A一起可形成连接体。 L是单键或连接体（连接原子或连接原子团），连接体的主链长度（主链原子数）是任意的，L可以含有也可以不含有C，N，O ，S，P和Si，并且可以包含或不包含单键，双键，三键，酰胺键，酯键，二硫键，亚氨基，醚 键，硫醚键和硫酯键。 Z是可以与标记化合物形成肽键的原子团，或是包括标记的原子或原子团。
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