公开(公告)号：US11365194B2

公开(公告)日：2022-06-21

申请号：US16650133

申请日：2018-09-27

Applicant: KAGOSHIMA UNIVERSITY ,  SHOWA UNIVERSITY

Inventor： Takashi Kurihara ,  Ichiro Takasaki ,  Naoki Toyooka ,  Hiroaki Gouda

IPC: C07D471/04 ,  C07D403/14

Abstract: This invention relates to an analgesic drug comprising a compound represented by the following formula (I) or (II), wherein R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

公开(公告)号：US09745275B2

公开(公告)日：2017-08-29

申请号：US15105985

申请日：2014-12-18

Applicant: KYOTO UNIVERSITY ,  KAGOSHIMA UNIVERSITY

Inventor： Masatoshi Hagiwara ,  Masayasu Toyomoto ,  Takamitsu Hosoya ,  Suguru Yoshida ,  Takashi Kurihara

IPC: A61K31/428 ,  C07D277/64

CPC classification number: C07D277/64

Abstract: Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.