公开(公告)号：US20220233577A1

公开(公告)日：2022-07-28

申请号：US16761107

申请日：2018-11-03

申请人： KALEIDO BIOSCIENCES, INC.

发明人： Molly Krisann Gibson ,  Nathan Wilson Stebbins ,  Ruth Thieroff-Ekerdt ,  Geoffrey A. von Maltzahn

IPC分类号： A61K31/716 ,  A61K47/10 ,  A61K35/741 ,  A61P3/12

摘要： Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.