公开(公告)号：US20190300465A1

公开(公告)日：2019-10-03

申请号：US16445264

申请日：2019-06-19

Applicant: KANEKA CORPORATION

Inventor： Koji MACHIDA ,  Hiroaki Yasukouchi ,  Akira Nishiyama

IPC: C07C37/74 ,  C07H1/06 ,  C07C37/56 ,  B01J41/12 ,  B01D15/36 ,  B01D3/14

Abstract: A high-purity alcohol compound can be obtained by a method comprising passing a solution containing an ester compound and methanol and/or ethanol through a column packed with an anion exchange resin having methoxide and/or ethoxide as a counter anion to generate a methyl ester and/or ethyl ester, and distilling off the methyl ester and/or ethyl ester together with the methanol and/or ethanol.

公开(公告)号：US20180305325A1

公开(公告)日：2018-10-25

申请号：US15758807

申请日：2016-09-01

Applicant: KANEKA CORPORATION

Inventor： Koji MACHIDA ,  Akira NISHIYAMA

IPC: C07D251/24

CPC classification number: C07D251/24 ,  B32B7/02 ,  C07D251/28 ,  G02B1/14 ,  G02B5/30

Abstract: The present invention provides methods respectively for producing a 2,4,6-tris(2-hydroxy-3-methyl-4-alkoxyphenyl)-1,3,5-triazine compound and 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine, both of which are improved in yield and quality. The methods according to the present invention are characterized in that a reaction of 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine with an alkylating agent is carried out using a base in the presence of an alcohol or water, and are also characterized in that an ester compound is used as an additive in a reaction of cyanuric chloride with 2-methylresorcinol.

公开(公告)号：US20220204451A1

公开(公告)日：2022-06-30

申请号：US17605408

申请日：2020-03-05

Applicant: KANEKA CORPORATION

Inventor： Koji MACHIDA ,  Hiroaki YASUKOUCHI ,  Akira NISHIYAMA

IPC: C07D213/81

Abstract: A method for producing a first vadadustat intermediate represented by the following formula (3) comprising reacting a compound represented by the following formula (1) with glycine or a glycine derivative represented by the following formula (2) or a salt of the glycine or the glycine derivative in the presence of carbon monoxide. The method produces a vadadustat intermediate through a clean reaction with high atom conversion efficiency.

公开(公告)号：US20170174622A1

公开(公告)日：2017-06-22

申请号：US15129927

申请日：2015-03-23

Applicant: KANEKA CORPORATION

Inventor： Koji MACHIDA ,  Kohei MORI ,  Narumi KISHIMOTO ,  Toshihiro TAKEDA

IPC: C07C277/08

CPC classification number: C07C277/08 ,  C07C279/24

Abstract: A tri-carbobenzoxy-arginine represented by the following formula (2): is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof: by adding carbobenzoxy chloride and a base in a water/organic solvent bilayer system to an arginine or arginine derivative (1) represented by the formula (1), or a salt thereof.