公开(公告)号：US11111184B2

公开(公告)日：2021-09-07

申请号：US15780643

申请日：2016-12-02

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Mei-Ling Ho ,  Li-Cheng Pan ,  Yin-Chih Fu ,  Chung-Hwan Chen ,  Je-Ken Chang

IPC: C04B35/64 ,  B22F1/00 ,  B22F3/10 ,  C04B35/634 ,  B33Y10/00 ,  B29C64/165 ,  C04B111/00 ,  B29C67/00 ,  C04B35/56 ,  C04B35/58 ,  C04B35/626 ,  C04B35/486 ,  C03B19/06 ,  C04B35/111 ,  C04B35/18 ,  C04B35/632 ,  B22F10/10 ,  B33Y70/00 ,  B28B1/00 ,  C04B35/447 ,  C04B38/00

Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.

公开(公告)号：US20220097257A1

公开(公告)日：2022-03-31

申请号：US17425953

申请日：2020-01-21

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Chih-Yun Lee ,  I-Chen Lee ,  Che-Wei Liu ,  Che-Wei Lin

IPC: B28B1/00 ,  B33Y70/10 ,  C08F220/56 ,  B33Y10/00 ,  B33Y80/00 ,  B33Y40/20 ,  C08K5/5397 ,  C08F2/50 ,  C04B35/447 ,  C04B35/48

Abstract: A method for preparing a slurry for photocuring 3D printing is provided, comprising the steps of: mixing monomer molecules of a thermosensitive hydrogel, a photocuring initiator, a crosslinking agent, a solvent, and a ceramic material to obtain the slurry. a method for manufacturing photocuring 3D printed articles is further provided, comprising using the slurry as a raw material, performing a 3D printing procedure by a photocuring 3D printer to obtain a green compact of a 3D printed article; and coating oil to the green compact of the 3D printed article, followed by heating and sintering the oil-coated article, to obtain the 3D printed article.

公开(公告)号：US20180354860A1

公开(公告)日：2018-12-13

申请号：US15780643

申请日：2016-12-02

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Mei-Ling Ho ,  Li-Cheng Pan ,  Yin-Chih Fu ,  Chung-Hwan Chen ,  Je-Ken Chang

IPC: C04B35/64 ,  B28B1/00 ,  B29C64/165 ,  C04B38/00 ,  C04B35/634

CPC classification number: C04B35/64 ,  B28B1/001 ,  B29C64/165 ,  B29C67/00 ,  B33Y10/00 ,  B33Y70/00 ,  C04B35/447 ,  C04B35/63416 ,  C04B38/00 ,  C04B38/0022 ,  C04B38/0045 ,  C04B2111/00836

Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.

公开(公告)号：US20150329592A1

公开(公告)日：2015-11-19

申请号：US14708305

申请日：2015-05-11

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Mei-Ling Ho ,  Chung-Hwan Chen ,  Yin-Chih Fu ,  Jia-Huie Lin ,  Chih-Yun Lee ,  Je-Ken Chang

IPC: C07K7/06

CPC classification number: C07K7/06 ,  C12Q1/34 ,  G01N33/542 ,  G01N33/587 ,  Y10T428/2982

Abstract: The present invention relates to a gold fluorescence resonance energy transfer nanoprobe comprising a gold fluorescence donor, a gold fluorescence acceptor, and a linker fragment that connects the gold fluorescence donor and the gold fluorescence acceptor, wherein the fluorescence resonance energy transfer is carried out between the gold fluorescence donor and the gold fluorescence acceptor. This all gold probe employing fluorescence resonance energy transfer technique can be used for detecting diseases such as arthritis, osteoporosis, and cancer metastasis.

Abstract translation: 本发明涉及金荧光共振能量转移纳米探针，其包含金荧光供体，金荧光受体和连接金荧光供体和金荧光受体的连接体片段，其中荧光共振能量转移在 金荧光供体和金荧光受体。 这种使用荧光共振能量转移技术的所有金探针可用于检测关节炎，骨质疏松症和癌症转移等疾病。

公开(公告)号：US20150265546A1

公开(公告)日：2015-09-24

申请号：US14662242

申请日：2015-03-19

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Li-Cheng Pan ,  Chih-Yun Lee ,  Hong-Jhe Lin ,  Che-Wei Lin ,  Po-Len Liu ,  Ping-Hsiu Shih

IPC: A61K9/51 ,  A61K31/7088 ,  A61K38/18 ,  A61K51/12 ,  A61K38/02

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/5115 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/18 ,  A61K49/0065

Abstract: The present invention relates to a nanoparticle carrier and the method for manufacturing the same. The nanoparticle carrier comprises hydrophobic molecules grafted with nanogold clusters and hydrophobic molecules grafted with hydrophilic molecules. The hydrophilic molecules are located on the outer layer of the nanoparticle and the nanogold clusters are wrapped inside the nanoparticle.

Abstract translation: 纳米粒子载体及其制造方法技术领域本发明涉及纳米粒子载体及其制造方法。 纳米颗粒载体包括用纳米金团簇接枝的疏水分子和用亲水分子接枝的疏水性分子。 亲水性分子位于纳米颗粒的外层上，并且纳米金簇聚集在纳米颗粒内。