公开(公告)号：US20180169136A1

公开(公告)日：2018-06-21

申请号：US15737312

申请日：2015-06-18

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-ling Ho ,  Je-Ken Chang ,  Shun-Cheng Wu ,  Chih-Hsiang Chang

IPC: A61K31/728 ,  A61K38/39 ,  A61K35/28 ,  A61K31/366 ,  A61K9/16 ,  A61P19/02

CPC classification number: A61K31/728 ,  A61K9/16 ,  A61K31/366 ,  A61K35/28 ,  A61K38/39 ,  A61K2300/00 ,  A61P19/02

Abstract: The present invention relates to a use of a pharmaceutical composition in the preparation of a drug for promoting chondrogenesis, wherein the pharmaceutical composition comprises a hyaluronic acid mixture and a statin compound.

公开(公告)号：US20150320876A1

公开(公告)日：2015-11-12

申请号：US14805588

申请日：2015-07-22

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Hui-Ting Chen ,  Kuang-Chan Hsieh ,  Je-Ken Chang ,  Gwo-Jaw Wang ,  Yin-Chih Fu ,  Mei-Ling Ho ,  Cherng-Chyi Tzeng

IPC: A61K47/48 ,  C08G73/02 ,  C08G69/48

CPC classification number: A61K47/48207 ,  A61K38/06 ,  A61K47/595 ,  C07K5/0815 ,  C08G69/48 ,  C08G73/028

Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.

Abstract translation: 提供了包括式（1A），（1B），（2）和（3）结构的发散确认的一系列肽。 在其中U，G，A，B，R 1，R 2和T如说明书中所定义的式中。 本发明中公开的发散肽的特征在于矿物结合亲和力。

公开(公告)号：US11344548B2

公开(公告)日：2022-05-31

申请号：US15557360

申请日：2015-10-08

Applicant: KAOHSIUNG MEDICAL UNIVERSITY ,  Alice Y Huang

Inventor： Hui-Ting Chen ,  Kuang-Chan Hsieh ,  Chai-Lin Kao ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: A61K31/505 ,  A61K47/64 ,  A61K31/40 ,  A61K31/44 ,  A61K31/47 ,  A61P19/10 ,  A61P19/08

Abstract: A method for treating low bone mineral density associated with osteopenia, osteoporosis, and other diseases is disclosed. The method comprises administrating a composition comprising a 3,5-dihydroxypentanoic acid derivative according to Formula I to a mammal. A compound of 3,5-dihydroxypentanoic acid derivative having a structure according to Formula I or Formula II is also disclosed.

公开(公告)号：US11111184B2

公开(公告)日：2021-09-07

申请号：US15780643

申请日：2016-12-02

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Mei-Ling Ho ,  Li-Cheng Pan ,  Yin-Chih Fu ,  Chung-Hwan Chen ,  Je-Ken Chang

IPC: C04B35/64 ,  B22F1/00 ,  B22F3/10 ,  C04B35/634 ,  B33Y10/00 ,  B29C64/165 ,  C04B111/00 ,  B29C67/00 ,  C04B35/56 ,  C04B35/58 ,  C04B35/626 ,  C04B35/486 ,  C03B19/06 ,  C04B35/111 ,  C04B35/18 ,  C04B35/632 ,  B22F10/10 ,  B33Y70/00 ,  B28B1/00 ,  C04B35/447 ,  C04B38/00

Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.

公开(公告)号：US10570365B2

公开(公告)日：2020-02-25

申请号：US15850320

申请日：2017-12-21

Applicant: Kaohsiung Medical University

Inventor： Che-Hsin Lin ,  Yao-Hsien Wang ,  Chung-Hwan Chen ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: C12M1/00 ,  G01N1/28 ,  B04B13/00 ,  B04B5/10 ,  G01N35/00 ,  G01N35/10 ,  C12M1/33 ,  B01L3/02 ,  B01L9/00 ,  G01N1/40 ,  B04B11/04

Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.

公开(公告)号：US20180328824A1

公开(公告)日：2018-11-15

申请号：US15850320

申请日：2017-12-21

Applicant: Kaohsiung Medical University

Inventor： Che-Hsin Lin ,  Yao-Hsien Wang ,  Chung-Hwan Chen ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: G01N1/40 ,  B01L3/02 ,  B01L9/00

Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.

公开(公告)号：US20150157762A1

公开(公告)日：2015-06-11

申请号：US14614718

申请日：2015-02-05

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu ,  Yao-Hsien Wang

IPC: A61L27/18 ,  A61L27/56 ,  A61L27/54

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  C08G63/912 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2207/10 ,  C08J2367/04 ,  C12N5/0667 ,  C12N2500/42 ,  C12N2501/999 ,  C12N2533/40 ,  C12N2537/10 ,  Y10T428/2982

Abstract: A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.

Abstract translation: 一种用于骨再生的方法，其包括将短期释放组合物施用到有需要的受试者的骨区域中，其中所述组合物包含交联的聚（乳酸 - 共 - 乙醇酸）阿仑膦酸钠（PLGA-ALN），其中 组合物将阿仑膦酸盐释放到骨区域中，其中骨区域的骨组织在9天内原位暴露于治疗有效量的阿仑膦酸盐。

公开(公告)号：US20180354860A1

公开(公告)日：2018-12-13

申请号：US15780643

申请日：2016-12-02

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Mei-Ling Ho ,  Li-Cheng Pan ,  Yin-Chih Fu ,  Chung-Hwan Chen ,  Je-Ken Chang

IPC: C04B35/64 ,  B28B1/00 ,  B29C64/165 ,  C04B38/00 ,  C04B35/634

CPC classification number: C04B35/64 ,  B28B1/001 ,  B29C64/165 ,  B29C67/00 ,  B33Y10/00 ,  B33Y70/00 ,  C04B35/447 ,  C04B35/63416 ,  C04B38/00 ,  C04B38/0022 ,  C04B38/0045 ,  C04B2111/00836

Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.

公开(公告)号：US20150329592A1

公开(公告)日：2015-11-19

申请号：US14708305

申请日：2015-05-11

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Mei-Ling Ho ,  Chung-Hwan Chen ,  Yin-Chih Fu ,  Jia-Huie Lin ,  Chih-Yun Lee ,  Je-Ken Chang

IPC: C07K7/06

CPC classification number: C07K7/06 ,  C12Q1/34 ,  G01N33/542 ,  G01N33/587 ,  Y10T428/2982

Abstract: The present invention relates to a gold fluorescence resonance energy transfer nanoprobe comprising a gold fluorescence donor, a gold fluorescence acceptor, and a linker fragment that connects the gold fluorescence donor and the gold fluorescence acceptor, wherein the fluorescence resonance energy transfer is carried out between the gold fluorescence donor and the gold fluorescence acceptor. This all gold probe employing fluorescence resonance energy transfer technique can be used for detecting diseases such as arthritis, osteoporosis, and cancer metastasis.

Abstract translation: 本发明涉及金荧光共振能量转移纳米探针，其包含金荧光供体，金荧光受体和连接金荧光供体和金荧光受体的连接体片段，其中荧光共振能量转移在 金荧光供体和金荧光受体。 这种使用荧光共振能量转移技术的所有金探针可用于检测关节炎，骨质疏松症和癌症转移等疾病。

公开(公告)号：US20210322411A1

公开(公告)日：2021-10-21

申请号：US15557360

申请日：2015-10-08

Applicant: Alice Y Huang ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Hui-Ting Chen ,  Kuang-Chan Hsieh ,  Chai-Lin Kao ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: A61K31/505 ,  A61K31/44 ,  A61K31/47 ,  A61K31/40 ,  A61K47/64

Abstract: A method for treating low bone mineral density associated with osteopenia, osteoporosis, and other diseases is disclosed. The method comprises administrating a composition comprising a 3,5-dihydroxypentanoic acid derivative according to Formula I to a mammal. A compound of 3,5-dihydroxypentanoic acid derivative having a structure according to Formula I or Formula II is also disclosed.