公开(公告)号：US11376266B2

公开(公告)日：2022-07-05

申请号：US16067906

申请日：2017-01-05

Applicant: KEIO UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hideyuki Saya ,  Osamu Nagano ,  Kenji Tsuchihashi ,  Kentaro Suina ,  Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Makoto Matsui ,  Keishiro Tomoda ,  Naoki Yamada ,  Tsukasa Nishimori

IPC: A61K31/635 ,  A61K47/60 ,  A61K9/00

Abstract: The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.

公开(公告)号：US09814707B2

公开(公告)日：2017-11-14

申请号：US15113932

申请日：2015-01-23

Applicant: Keio University

Inventor： Hideyuki Saya ,  Osamu Nagano ,  Shogo Okazaki

IPC: A61K31/454 ,  A61K31/655 ,  A61K45/06

CPC classification number: A61K31/454 ,  A61K31/655 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention is directed to provide cancer stem cell proliferation inhibitors and inducers of intracellular accumulation of reactive oxygen species. To this end, provided are cancer stem cell proliferation inhibitors and inducers of intracellular accumulation of reactive oxygen species in a cancer stem cell each containing pimozide or sertindole as an active ingredient.