公开(公告)号：US20170322212A1

公开(公告)日：2017-11-09

申请号：US15526939

申请日：2014-11-27

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Bao Trong Do ,  Jonathan Hofmekler ,  Cesar A. Morales ,  David W. Koenig ,  Yang Huang ,  Aimin He

IPC: G01N33/569 ,  G01N33/558

CPC classification number: G01N33/56983 ,  G01N33/558 ,  G01N2333/08 ,  G01N2469/10

Abstract: Lateral-flow assay and time-resolved fluorescence technologies provide a sensitive tool for detecting norovirus particles in a sample. A flow-through assay device employs norovirus and norovirus G2 antibodies. The lateral-flow assay includes a conjugate pad having conjugated probes. The conjugated probes are particles modified with a binding member that is configured to bind with a norovirus. The particles also have a fluorescent label. A general method of detecting the virus includes (i) preparing a sample with contaminants, (ii) processing the sample and depositing it onto the assay device, and (iii) measuring the fluorescence signal.

公开(公告)号：US10209256B2

公开(公告)日：2019-02-19

申请号：US15526939

申请日：2014-11-27

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Bao Trong Do ,  Jonathan Hofmekler ,  Cesar A. Morales ,  David W. Koenig ,  Yang Huang ,  Aimin He

IPC: G01N33/547 ,  G01N33/569 ,  G01N33/558

Abstract: Lateral-flow assay and time-resolved fluorescence technologies provide a sensitive tool for detecting norovirus particles in a sample. A flow-through assay device employs norovirus and norovirus G2 antibodies. The lateral-flow assay includes a conjugate pad having conjugated probes. The conjugated probes are particles modified with a binding member that is configured to bind with a norovirus. The particles also have a fluorescent label. A general method of detecting the virus includes (i) preparing a sample with contaminants, (ii) processing the sample and depositing it onto the assay device, and (iii) measuring the fluorescence signal.