公开(公告)号：US09670240B2

公开(公告)日：2017-06-06

申请号：US15286408

申请日：2016-10-05

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Phil Ho Lee ,  Seo Hyun Shin ,  Dong Jin Kang ,  Da Han Eom ,  Yea Rin Kim ,  Yeon Seok Jeong ,  Won Seok Choi

IPC: C07F9/6571 ,  C07F9/6574

CPC classification number: C07F9/657181 ,  C07F9/657172 ,  C07F9/65744

Abstract: Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.

公开(公告)号：US09487547B2

公开(公告)日：2016-11-08

申请号：US14598143

申请日：2015-01-15

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Phil Ho Lee ,  Seo Hyun Shin ,  Dong Jin Kang ,  Da Han Eom ,  Yea Rin Kim ,  Yeon Seok Jeong ,  Won Seok Choi

IPC: C07F9/6571 ,  C07F9/6584 ,  C07F9/6574

CPC classification number: C07F9/657181 ,  C07F9/657172 ,  C07F9/65744

Abstract: Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.

Abstract translation: 提供新的环状次膦酸盐衍生物及其制备方法，更具体地说，包括苯并氧磷杂环磷氧化物衍生物和苯并氧磷化磷氧化物衍生物的环状次膦酸盐衍生物及其制备方法。 根据本发明的环状次膦酸盐衍生物可具有药理和生理活性，可用作天然物质的基本骨架，并用于开发新药物和各种药物的合成。 此外，通过制备本发明的环状次膦酸酯衍生物的方法，可以通过简单的合成方法通过在次膦酸衍生物上进行分子内碳 - 氧偶联反应，在存在的情况下以高收率制备各种环状次膦酸酯衍生物 的钯（Pd）催化剂，氧化剂和碱。

公开(公告)号：US20150315219A1

公开(公告)日：2015-11-05

申请号：US14598143

申请日：2015-01-15

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Phil Ho Lee ,  Seo Hyun Shin ,  Dong Jin Kang ,  Da Han Eom ,  Yea Rin Kim ,  Yeon Seok Jeong ,  Won Seok Choi

IPC: C07F9/6574

CPC classification number: C07F9/657181 ,  C07F9/657172 ,  C07F9/65744

Abstract: Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.

Abstract translation: 提供新的环状次膦酸盐衍生物及其制备方法，更具体地说，包括苯并氧磷杂环磷氧化物衍生物和苯并氧磷化磷氧化物衍生物的环状次膦酸盐衍生物及其制备方法。 根据本发明的环状次膦酸盐衍生物可具有药理和生理活性，可用作天然物质的基本骨架，并用于开发新药物和各种药物的合成。 此外，通过制备本发明的环状次膦酸酯衍生物的方法，可以通过简单的合成方法通过在次膦酸衍生物上进行分子内碳 - 氧偶联反应，在存在的情况下以高收率制备各种环状次膦酸酯衍生物 的钯（Pd）催化剂，氧化剂和碱。