公开(公告)号：US20240066059A1

公开(公告)日：2024-02-29

申请号：US18279965

申请日：2022-03-03

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Byung Soo KIM ,  Mi Kyung KANG ,  Hee Ho PARK

IPC: A61K35/15 ,  A61K39/00 ,  A61P35/00 ,  C07K14/555 ,  C07K14/705 ,  C12N5/0786 ,  C12N9/12 ,  C12N11/08

CPC classification number: A61K35/15 ,  A61K39/4614 ,  A61K39/4631 ,  A61K39/464402 ,  A61P35/00 ,  C07K14/555 ,  C07K14/705 ,  C12N5/0645 ,  C12N9/1241 ,  C12N11/08 ,  A61K2239/15 ,  A61K2239/17 ,  A61K2239/21 ,  A61K2239/22

Abstract: A method for producing CAR-M1 macrophages expressing a chimeric antigen receptor in vitro and in vivo includes using a conjugate of a non-viral gene delivery system and a chimeric antigen receptor gene. The CAR-M1 macrophages are produced in vivo by delivering genes encoding a chimeric antigen receptor and IFN-γ, specifically to macrophages in the body, and thus does not require culturing and preparing an in-vitro cellular therapeutic agent, thus reducing the manufacturing costs of therapeutic agents. The CAR-M1 macrophages are a safer therapy since a non-viral vector is used, as compared to the production of CAR-M1 macrophages by gene delivery using a viral vector, and are a novel therapeutic candidate having the advantage of high anticancer efficiency for solid cancers, due to CAR-M1 macrophages in which intrinsic properties of macrophages infiltrating solid cancers and cancer cell phagocytosis are improved.

公开(公告)号：US20230392110A1

公开(公告)日：2023-12-07

申请号：US18328308

申请日：2023-06-02

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Duck Hwan PARK ,  Dong Hyuk CHOI ,  Hyun Ju CHOI ,  Yeon Ju KIM ,  Yeon Jeong LIM ,  In Gyeong LEE

IPC: C12N1/20 ,  A01N63/22 ,  A01P1/00

CPC classification number: C12N1/20 ,  A01N63/22 ,  A01P1/00

Abstract: The present invention relates to antagonist microorganisms for inhibiting fire blight and a composition for preventing or inhibiting fire blight comprising the same as an active ingredient, and provides antagonist microorganisms exhibiting excellent antagonistic ability against a causative bacterium, Erwinia amylovora. According to the present invention, the antagonist microorganisms for inhibiting fire blight isolated in Korea are provided to replace a biological control agent for inhibiting fire blight, which requires enormous costs depending on imports.

公开(公告)号：US20220218203A1

公开(公告)日：2022-07-14

申请号：US17607751

申请日：2020-07-30

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION ,  C&V TECH INC.

Inventor： Byeong Hee KIM ,  Young Ho SEO ,  Hyung Jin KIM ,  Min Jae JEONG ,  Dong Uk KIM ,  Jin Hue KANG

IPC: A61B3/16 ,  G01J1/08

Abstract: The present invention relates to a non-contact portable tonometry system and tonometry method using a difference in infrared intensity. A nozzle module receives compressed air from a compressed air supply source and sprays the same through an air spray port to a cornea of a subject, thus to cause corneal deformation. An infrared ray sensor is disposed in the nozzle module to emit infrared rays to the cornea and measure an amount of light reflected from the cornea. A controller converts the amount of light measured by the infrared ray sensor before and after the deformation of corneal into intraocular pressure.

公开(公告)号：US20220004701A1

公开(公告)日：2022-01-06

申请号：US17309853

申请日：2021-06-22

Applicant: Samsung Electronics Co., Ltd. ,  KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Chiwoo SONG ,  Honghee GIL ,  Saegyeol LEE ,  Changki LEE ,  Youngchan CHOI

IPC: G06F40/166 ,  G06F40/253 ,  G06F40/279 ,  G06F40/30 ,  G06N20/00

Abstract: Provided is an electronic device including a communication module, a memory, and at least one processor operatively connected to the communication module and the memory, and the memory stores instructions configured to, when executed, enable the at least one processor to: receive a first sentence via the communication module; identify a first newly coined word included in the first sentence; obtain a second sentence by identifying a first alternative word corresponding to the first newly coined word, and replacing the first newly coined word in the first sentence with the first alternative word; obtain a third sentence by correcting a grammatical error in the second sentence based on the first alternative word occurring the grammatical error when replacing the first newly coined word; and transmit the third sentence to an external device via the communication module. Other embodiments can be made.

公开(公告)号：US20210119658A1

公开(公告)日：2021-04-22

申请号：US16929618

申请日：2020-07-15

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Kuduck Kwon ,  Beomyu Park

IPC: H04B1/16 ,  H03F3/45

Abstract: A low-power double-quadrature receiver is disclosed. The double-quadrature receiver includes a quadrature signal generator configured to generate a first quadrature signal and a second quadrature signal based on each component of a differential input signal, and a switching stage configured to perform down-conversion on the first quadrature signal and the second quadrature signal.

公开(公告)号：US20190388664A1

公开(公告)日：2019-12-26

申请号：US16453529

申请日：2019-06-26

Applicant: KNU-Industry Cooperation Foundation

Inventor： Kwang Ho LEE

IPC: A61M31/00 ,  C08J3/24 ,  C08J3/075

Abstract: Provided is a method of controlling local release of target compounds by patterning a hydrogel carrying a bone morphogenetic protein as the target compounds on a nanoporous membrane. The nanoporous membrane is capable of controlling local release of the bone morphogenetic protein as a carrier of the bone morphogenetic protein while performing a basic function of the membrane of preventing infiltration of connective tissue, and thus, there is an advantage in that the nanoporous membrane can facilitate generation of controlled bone in a local region.

公开(公告)号：US10323033B2

公开(公告)日：2019-06-18

申请号：US16004188

申请日：2018-06-08

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Phil Ho Lee

IPC: C07D471/04 ,  B01J31/04

Abstract: Provided are an imidazo[1,2-a]pyridine-3-carboxylate derivative and a preparation method thereof, and more particularly, a method of effectively preparing an imidazo[1,2-a]pyridine-3-carboxylate derivative by performing an aza-[3+2] cycloaddition reaction of a pyridine derivative with an α-diazo oxime ether derivative in the presence of a copper (II) catalyst, and an imidazo[1,2-a]pyridine-3-carboxylate derivative prepared thereby.

公开(公告)号：US20170073389A1

公开(公告)日：2017-03-16

申请号：US15122833

申请日：2015-11-23

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION ,  SUPADELIXIR INC.

Inventor： Jang-Hee HAHN ,  Dong-Young LIM

IPC: C07K14/705 ,  A61K8/64 ,  A61Q19/02

CPC classification number: C07K14/705 ,  A61K8/64 ,  A61K8/66 ,  A61K2800/782 ,  A61Q19/02 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1019 ,  C07K7/06 ,  G01N33/53

Abstract: Provided is a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), i.e., a peptide fragment selected from the group consisting of the peptides as set forth in SEQ ID NOs: 1 to 9 and a cosmetic composition for skin-whitening and/or inhibiting skin pigmentation comprising the same as an active ingredient. The peptide fragment inhibits melanin formation in melanocytes, thereby having an inhibitory activity against skin pigmentation. Further provided is a reagent for researching or analyzing the inhibition of Wnt signaling pathways comprising the peptide fragment.

Abstract translation: 提供衍生自分泌性卷曲蛋白5（Sfrp5）的肽片段，即选自SEQ ID NO：1〜9所示的肽的肽片段和用于皮肤美白的化妆品组合物和/或 抑制包含其作为活性成分的皮肤色素沉着。 肽片段抑制黑素细胞中的黑色素形成，从而具有抗皮肤色素沉着的抑制活性。 还提供了用于研究或分析包含肽片段的Wnt信号传导途径的抑制的试剂。

公开(公告)号：US20150180019A1

公开(公告)日：2015-06-25

申请号：US14635182

申请日：2015-03-02

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Sung-man LEE ,  Jong-hyuk LEE

IPC: H01M4/04 ,  H01M4/38 ,  H01M4/587 ,  H01M4/36 ,  H01M4/134 ,  H01M4/133

CPC classification number: H01M4/38 ,  H01M4/133 ,  H01M4/134 ,  H01M4/364 ,  H01M4/366 ,  H01M4/386 ,  H01M4/387 ,  H01M4/587 ,  H01M10/0525 ,  Y02E60/122 ,  Y02P70/54

Abstract: The present invention relates to a negative active material for a rechargeable lithium battery, a method of manufacturing the negative active material, and a rechargeable lithium battery including the negative active material. The negative active material includes a first graphite particle including graphite pieces; and at least one second particle selected from the group consisting of an element particle, an element compound particle, a composite particle, and a carbon composite particle, and a combination particle thereof, wherein the element particle, the element compound particle, the composite particle, and the carbon composite particle are selected from the group consisting of Si, Sn, Al, Ge, Pb, and combinations thereof; wherein each of the graphite pieces has a thickness ranging from 0.01 μm to 0.1 μm and the graphite pieces are linked to one another forming a curved side; and wherein the at least one second particle is dispersed between the graphite pieces.

Abstract translation: 本发明涉及一种用于可再充电锂电池的负极活性材料，负极活性材料的制造方法以及包含负极活性材料的可再充电锂电池。 负极活性物质包括包含石墨片的第一石墨粒子; 以及选自元素粒子，元素化合物粒子，复合粒子，碳复合粒子等的至少一种第二粒子及其组合粒子，其中，元素粒子，元素化合物粒子，复合粒子 ，碳复合粒子选自Si，Sn，Al，Ge，Pb及其组合; 其中每个石墨片具有0.01μm至0.1μm的厚度，并且所述石墨片彼此连接形成弯曲侧; 并且其中所述至少一个第二颗粒分散在所述石墨片之间。

公开(公告)号：US20140065488A1

公开(公告)日：2014-03-06

申请号：US13969812

申请日：2013-08-19

Applicant: KNU-Industry Cooperation Foundation

Inventor： Sung-Man LEE ,  Yoon-Soo Park

IPC: C01B31/04 ,  H01M4/583

CPC classification number: C01B31/04 ,  C01B32/20 ,  H01M4/0402 ,  H01M4/0471 ,  H01M4/133 ,  H01M4/1393 ,  H01M4/587 ,  H01M10/052 ,  Y02P70/54 ,  Y10T428/2982

Abstract: Disclosed are a method of preparing a negative active material for a rechargeable lithium battery that includes preparing a solution including spherically shaped natural graphite particles and a solvent, ultrasonic wave-treating the solution, and drying the ultrasonic wave-treated solution to prepare graphite modified particles, and a rechargeable lithium battery prepared therefrom.

Abstract translation: 公开了一种制备用于可再充电锂电池的负极活性材料的方法，包括制备包括球形天然石墨颗粒和溶剂的溶液，对溶液进行超声波处理，并干燥超声波处理溶液以制备石墨改性颗粒 和由其制备的可再充电锂电池。