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    Phosphinine oxide derivative and preparation method thereof
    2.
    发明授权
    Phosphinine oxide derivative and preparation method thereof 有权
    氧化膦衍生物及其制备方法

    公开(公告)号：US09493494B2

    公开(公告)日：2016-11-15

    申请号：US14473901

    申请日：2014-08-29

    Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

    Inventor： Phil Ho Lee ,  Young Chul Park ,  In Cheol Jeon ,  Jung Min Seo ,  Bo Ram Seo

    IPC: C07F9/6584 ,  C07F9/6571

    CPC classification number: C07F9/65846 ,  C07F9/657163 ,  C07F9/657172 ,  C07F9/657181

    Abstract: Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative.The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies.In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.

    Abstract translation: 此外，根据本发明的次膦氧化物衍生物的制备方法，可以通过使用在次膦酸衍生物和炔衍生物之间的分子内环状的简单的合成方法，在存在下制备具有高产率的各种次膦酰氧化物衍生物 的铑（Rh）催化剂或钌（Ru）催化剂和氧化剂。

    Cyclic phosphinate derivatives and method of preparing the same
    4.
    发明授权
    Cyclic phosphinate derivatives and method of preparing the same 有权

    公开(公告)号：US09670240B2

    公开(公告)日：2017-06-06

    申请号：US15286408

    申请日：2016-10-05

    Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

    Inventor： Phil Ho Lee ,  Seo Hyun Shin ,  Dong Jin Kang ,  Da Han Eom ,  Yea Rin Kim ,  Yeon Seok Jeong ,  Won Seok Choi

    IPC: C07F9/6571 ,  C07F9/6574

    CPC classification number: C07F9/657181 ,  C07F9/657172 ,  C07F9/65744

    Abstract: Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.

    Cyclic phosphinate derivatives and method of preparing the same
    5.
    发明授权
    Cyclic phosphinate derivatives and method of preparing the same 有权
    环状次膦酸酯衍生物及其制备方法

    公开(公告)号：US09487547B2

    公开(公告)日：2016-11-08

    申请号：US14598143

    申请日：2015-01-15

    Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

    Inventor： Phil Ho Lee ,  Seo Hyun Shin ,  Dong Jin Kang ,  Da Han Eom ,  Yea Rin Kim ,  Yeon Seok Jeong ,  Won Seok Choi

    IPC: C07F9/6571 ,  C07F9/6584 ,  C07F9/6574

    CPC classification number: C07F9/657181 ,  C07F9/657172 ,  C07F9/65744

    Abstract: Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.

    Abstract translation: 提供新的环状次膦酸盐衍生物及其制备方法，更具体地说，包括苯并氧磷杂环磷氧化物衍生物和苯并氧磷化磷氧化物衍生物的环状次膦酸盐衍生物及其制备方法。 根据本发明的环状次膦酸盐衍生物可具有药理和生理活性，可用作天然物质的基本骨架，并用于开发新药物和各种药物的合成。 此外，通过制备本发明的环状次膦酸酯衍生物的方法，可以通过简单的合成方法通过在次膦酸衍生物上进行分子内碳 - 氧偶联反应，在存在的情况下以高收率制备各种环状次膦酸酯衍生物 的钯（Pd）催化剂，氧化剂和碱。

    NOVEL PHOSPHININE OXIDE DERIVATIVE AND PREPARATION METHOD THEREOF
    6.
    发明申请
    NOVEL PHOSPHININE OXIDE DERIVATIVE AND PREPARATION METHOD THEREOF 有权
    新型磷酰氧化物衍生物及其制备方法

    公开(公告)号：US20150344506A1

    公开(公告)日：2015-12-03

    申请号：US14473901

    申请日：2014-08-29

    Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

    Inventor： Phil Ho Lee ,  Young Chul Park ,  In Cheol Jeon ,  Jung Min Seo ,  Bo Ram Seo

    IPC: C07F9/6584 ,  C07F9/6571

    CPC classification number: C07F9/65846 ,  C07F9/657163 ,  C07F9/657172 ,  C07F9/657181

    Abstract: Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative.The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies.In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.

    Abstract translation: 提供了一种新型的次膦酰氧化物衍生物及其制备方法，更具体地说，该次膦酰氧化物衍生物包括氧化磷腈氧化物衍生物和氮代膦酸氧化物衍生物。 本发明的次膦氧化物衍生物可以具有药理活性和生理活性，可以作为天然产物的基本框架使用，可用于新药的开发和各种医疗用品的合成。 此外，根据本发明的次膦氧化物衍生物的制备方法，可以通过使用在次膦酸衍生物和炔衍生物之间的分子内环状的简单的合成方法，在存在下制备具有高产率的各种次膦酰氧化物衍生物 的铑（Rh）催化剂或钌（Ru）催化剂和氧化剂。

    NOVEL CYCLIC PHOSPHINATE DERIVATIVES AND METHOD OF PREPARING THE SAME
    8.
    发明申请
    NOVEL CYCLIC PHOSPHINATE DERIVATIVES AND METHOD OF PREPARING THE SAME 有权
    新型环磷酰胺衍生物及其制备方法

    公开(公告)号：US20150315219A1

    公开(公告)日：2015-11-05

    申请号：US14598143

    申请日：2015-01-15

    Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

    Inventor： Phil Ho Lee ,  Seo Hyun Shin ,  Dong Jin Kang ,  Da Han Eom ,  Yea Rin Kim ,  Yeon Seok Jeong ,  Won Seok Choi

    IPC: C07F9/6574

    CPC classification number: C07F9/657181 ,  C07F9/657172 ,  C07F9/65744

    Abstract: Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.

    Abstract translation: 提供新的环状次膦酸盐衍生物及其制备方法，更具体地说，包括苯并氧磷杂环磷氧化物衍生物和苯并氧磷化磷氧化物衍生物的环状次膦酸盐衍生物及其制备方法。 根据本发明的环状次膦酸盐衍生物可具有药理和生理活性，可用作天然物质的基本骨架，并用于开发新药物和各种药物的合成。 此外，通过制备本发明的环状次膦酸酯衍生物的方法，可以通过简单的合成方法通过在次膦酸衍生物上进行分子内碳 - 氧偶联反应，在存在的情况下以高收率制备各种环状次膦酸酯衍生物 的钯（Pd）催化剂，氧化剂和碱。

    Dihydro-1H-phosphole 1-oxide derivatives and preparation method thereof
    9.
    发明授权
    Dihydro-1H-phosphole 1-oxide derivatives and preparation method thereof 有权
    二氢1H-磷酸1-氧化物衍生物及其制备方法

    公开(公告)号：US09073956B1

    公开(公告)日：2015-07-07

    申请号：US14595448

    申请日：2015-01-13

    Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

    Inventor： Phil Ho Lee ,  Tae Kyu Ryu ,  Sang June Park

    IPC: C07F9/6571 ,  C07F9/6584

    CPC classification number: C07F9/657181 ,  C07F9/65844

    Abstract: Provided are novel dihydro-1H-phosphole 1-oxide derivatives and a preparation method thereof. More particularly, the dihydro-1H-phosphole 1-oxide derivatives include 1,3-dihydro-1H-2,1-oxaphosphole 1-oxide derivatives and 2,3-dihydro-1H-2,1-azaphosphole 1-oxide derivatives. Further, in the preparation method of a dihydro-1H-phosphole 1-oxide derivative according to the present invention, various phosphinine oxide derivatives may be prepared with high yield by a simple synthesis process by reacting a phosphinic derivative and a vinyl derivative with each other in the presence of a rhodium (Rh) catalyst, an oxidant, and a base.

    Abstract translation: 提供新的二氢-1H-磷酸1-氧化物衍生物及其制备方法。 更具体地，二氢-1H-磷酸1-氧化物衍生物包括1,3-二氢-1H-2,1-氧代磷杂环1-氧化物衍生物和2,3-二氢-1H-2,1-氮杂磷杂环1-氧化物衍生物。 此外，在本发明的二氢-1H-磷酸1-氧化物衍生物的制备方法中，可以通过简单的合成方法通过使次膦基衍生物和乙烯基衍生物彼此反应来制备各种次膦酸氧化物衍生物 在铑（Rh）催化剂，氧化剂和碱的存在下。

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