公开(公告)号：US20190388664A1

公开(公告)日：2019-12-26

申请号：US16453529

申请日：2019-06-26

Applicant: KNU-Industry Cooperation Foundation

Inventor： Kwang Ho LEE

IPC: A61M31/00 ,  C08J3/24 ,  C08J3/075

Abstract: Provided is a method of controlling local release of target compounds by patterning a hydrogel carrying a bone morphogenetic protein as the target compounds on a nanoporous membrane. The nanoporous membrane is capable of controlling local release of the bone morphogenetic protein as a carrier of the bone morphogenetic protein while performing a basic function of the membrane of preventing infiltration of connective tissue, and thus, there is an advantage in that the nanoporous membrane can facilitate generation of controlled bone in a local region.

公开(公告)号：US20230172865A1

公开(公告)日：2023-06-08

申请号：US18153590

申请日：2023-01-12

Applicant: KNU-Industry Cooperation Foundation

Inventor： Kwang Ho LEE

IPC: A61K9/48 ,  A61K9/28 ,  A61K9/70 ,  A61K9/20

CPC classification number: A61K9/4825 ,  A61K9/286 ,  A61K9/2086 ,  A61K9/7007

Abstract: Provided is a method of controlling local release of target compounds by patterning a hydrogel carrying a bone morphogenetic protein or anticancer drug as the target compounds onto an electrospun nanoporous membrane. The hydrogel is capable of controlling local release of the bone morphogenetic protein or anticancer drug as a carrier of the bone morphogenetic protein or anticancer. And the electrospun nanoporous membrane performs a basic function of the membrane of preventing infiltration of connective tissue. Thus, there is an advantage in that the hydrogel patterned nanoporous membrane can facilitate generation of controlled bone in a local region and degradation of cancer in a local region.

公开(公告)号：US20200289017A1

公开(公告)日：2020-09-17

申请号：US16642822

申请日：2018-06-19

Applicant: KNU-Industry Cooperation Foundation

Inventor： Kwang Ho LEE

IPC: A61B5/05 ,  A61B5/053 ,  A61L31/04 ,  A61L31/08 ,  A61L31/14 ,  C08J7/04 ,  C08J7/044 ,  B33Y10/00 ,  B33Y40/10 ,  B33Y40/20 ,  B33Y70/00 ,  B29C64/106 ,  B29C64/314 ,  B29C64/35 ,  B29C64/386 ,  B33Y50/00 ,  B33Y80/00 ,  D01D1/02 ,  D01D5/00

Abstract: The present invention relates to a bio-electrode having improved conductivity, flexibility and bio-compatibility, and a method of manufacturing the same. Specifically, the present invention relates to a conductive polymer bio-electrode including nano-porous permeable membrane, based on a bio-compatible polymer material having a plurality of pores and an improved surface area based on a PDMS device having a low mechanical strength and an excellent bio-compatibility, bio-signal transmission patterning, and a gold coating layer and has an excellent bio-compatibility and low rejection response while having a conductivity similar to that of a bio-electrode configured with a metal material of the related art. Therefore, the conductive polymer bio-electrode of the present invention is expected to be able to replace a bio-electrode configured with a metal material by which the bio-signal transmission efficiency is degraded due to a high bio-incompatibility.