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公开(公告)号：US20210164996A1
公开(公告)日：2021-06-03
申请号：US17046473
申请日：2019-04-12
发明人： Gerben KOOIJMAN , Amir Hussein RMAILE , Carl GLASSE , Marinus Karel Johannes DE JAGER , Iain Leslie Campbell CHAPPLE , Melissa Mackay GRANT , Philip PRESHAW , John J TAYLOR , Michael Alex VAN HARTSKAMP
IPC分类号： G01N33/68
摘要： Disclosed is an in vitro method for assessing whether a human patient has periodontitis. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the certain protein combinations. One such combination is Alpha-1-acid glycoprotein (A1AGP) and at least one of Profilin and S100 calcium-binding protein A9 (S100A9). Another combination is Pyruvate Kinase (PK) and S100 calcium-binding protein A8 (S100A8). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for absence of periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for periodontitis in said patient.
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公开(公告)号：US20230218376A1
公开(公告)日：2023-07-13
申请号：US17927694
申请日：2021-05-20
发明人： Lutz Christian GERHARDT , Neil Francis JOYE , Mark Thomas JOHNSON , Achim Rudolf HILGERS , Amir Hussein RMAILE
CPC分类号： A61C17/00 , A46B15/0022 , A46B15/0006 , B08B7/00 , A46B2200/1066
摘要： An oral care device (8) adapted to generate an RF field for performing an oral cleaning function. The device includes a cleaning unit (10) for receipt in the mouth which includes a conductor arrangement (18, 19) which is driven with a drive signal to generate an RF field which cleans surfaces in the mouth. Means is further provided for sensing an electrical or electromagnetic signal arising from interaction of the RF energy with bodies in the mouth, for performing a sensing function with the same RF system components used for generating the RF field for cleaning or treatment.
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公开(公告)号：US20220323186A1
公开(公告)日：2022-10-13
申请号：US17641028
申请日：2020-08-28
摘要： In the context of dental care, a system (100) is provided which comprises i) an appliance (110) that is configured to operate a functional unit, ii) a data providing arrangement (120) that is configured to include operation data in the form of respective combinations of a mouth area and an effective time duration of a dental care action for the area concerned, wherein the effective time durations of the respective combinations add up to a total operation time of a dental care procedure and have respective values according to a proportional division of the total operation time on the basis of a distribution of the extent to which dental care is needed at the areas of the respective combinations, and iii) a controller (130) that is configured to communicate with the data providing arrangement (120) and to control operation of the appliance (110) in accordance with the operation data.
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公开(公告)号：US20240180680A1
公开(公告)日：2024-06-06
申请号：US18286100
申请日：2022-04-06
CPC分类号： A61C17/228 , A61B5/11 , A61B5/228 , A61B5/389 , A61B5/682
摘要： An approach for obtaining measurements of mechanical properties of a gripping performed by masticatory apparatus. A mouthpiece provides a sensing arrangement (for obtaining the measurement) and one or more mouth contacting elements for protecting, cleaning or treating teeth/gums. In this way, measurements indicative of potential abnormalities or physiological dysfunction in the masticatory apparatus can be obtained using a mouthpiece that has a secondary function of protecting, cleaning and/or treating elements of the mouth.
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公开(公告)号：US20230393149A1
公开(公告)日：2023-12-07
申请号：US18236453
申请日：2023-08-22
发明人： Gerben KOOIJMAN , Michael Alex VAN HARTSKAMP , Marinus Karel Johannes DE JAGER , Amir Hussein RMAILE , Philip PRESHAW , John J. TAYLOR
CPC分类号： G01N33/6893 , G16H10/40 , G01N2333/4737 , G01N2333/4753 , G01N2333/545 , G01N2800/18 , G01N2800/60
摘要： Disclosed is an in vitro method for assessing the presence of gingivitis in a human subject. The method is based on the insight to determine a selection of three biomarker proteins. Accordingly, in a saliva sample of the subject the concentrations are measured of the proteins Hepatocyte growth factor (HGF) and Interleukin-1β (IL-1β), and at least one of C reactive protein (CRP) and Haemoglobin. Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with the absence of gingivitis or periodontitis. The comparison allows to assessing whether the testing value is indicative of the presence of gingivitis in said subject. Thereby, typically, a testing value reflecting a joint concentration above the joint concentration reflected by the threshold, is indicative of the presence of gingivitis.
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公开(公告)号：US20210181209A1
公开(公告)日：2021-06-17
申请号：US16758902
申请日：2018-10-18
发明人： Supriyo CHATTERJEA , Marinus Karel Johannes DE JAGER , Amir Hussein RMAILE , Gerben KOOIJMAN , Michael Alex VAN HARTSKAMP , Philip PRESHAW , John J TAYLOR
IPC分类号： G01N33/68
摘要： Disclosed is a system, a kit, a use and an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The system and method are based on the insight to apply a clustering technique to a reference set of patient data, and then further discriminating the sets of bio markers to be applied. The clusters are determined on the basis of the biomarkers Hepatocyte Growth Factor (HGF), Matrix metalloproteinase 8 (MMP8), and Matrix metalloproteinase 9 (MMP9). The actual classification of the patient is done on the basis of the measurement of the concentrations of either of two sets of biomarkers. For one cluster these are Interleukin-1β (IL1β), Interleukin-6 (IL6), and Collagen Telopeptide. For the other cluster, these are HGF and metallopeptidase inhibitor 1 (TIMP1).
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公开(公告)号：US20240296558A1
公开(公告)日：2024-09-05
申请号：US18572704
申请日：2022-06-10
CPC分类号： G06T7/0012 , G06T7/62 , G06T2207/10116 , G06T2207/20081 , G06T2207/30036
摘要： A method for performing a non-invasive periodontal examination on a subject. The method comprises obtaining a first optical image of the surface of an intra-oral area of the subject, the intra-oral area containing at least one tooth and a corresponding gum and obtaining a second image of the intra-oral area of the subject, wherein the second image contains an image of the hard tissue covered by the soft tissue. The hard tissue includes bone and teeth. The method further comprises merging the optical image and the second image into a fused image such that the tooth and part of the gum in the fused image are based on the optical image and wherein any bone in the fused image is based on the second image and estimating the periodontal distance between a soft tissue landmark and a hard tissue landmark for each tooth in the intra-oral area based on the fused image.
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公开(公告)号：US20240268548A1
公开(公告)日：2024-08-15
申请号：US18568802
申请日：2022-06-07
CPC分类号： A46B13/023 , A46B15/0004 , A61B5/14539 , A46B2200/1066
摘要： A power toothbrush has a toothbrush head and a handle for driving the toothbrush head with a vibratory motion using drive parameters. The apply drive parameters are adapted based on a sensed pH level. In this way, the brushing can be adapted to the acidity levels presents, and thereby reduce the risk of damage to the teeth caused by excessively hard brushing in an acidic environment.
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公开(公告)号：US20210382069A1
公开(公告)日：2021-12-09
申请号：US17045312
申请日：2019-04-02
发明人： Gerben KOOIJMAN , Amir Hussein RMAILE , Carl GLASSE , Marinus Karel Johannes DE JAGER , Iain Leslie Campbell CHAPPLE , Melissa Mackay GRANT , Philip PRESHAW , John J TAYLOR , Michael Alex VAN HARTSKAMP
摘要： Disclosed is an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The method is based on the insight to determine a selection of three bio marker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the proteins Pyruvate Kinase (PK) and at least two of Haemoglobin-beta (Hb-beta), Haemoglobin-delta (Hb-delta), S100 calcium-binding protein A8 (S100A8) and S100 calcium-binding protein A9 (S100A9). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of advanced periodontitis or of mild periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for mild periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for advanced periodontitis in said patient.
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10.发明申请公开(公告)号：US20210164994A1
公开(公告)日：2021-06-03
申请号：US17045344
申请日：2019-04-02
发明人： Gerben KOOIJMAN , Michael Alex VAN HARTSKAMP , Amir Hussein RMAILE , Carl GLASSE , Philip PRESHAW , John TAYLOR , Iain Leslie Campbell CHAPPLE , Melissa Mackay GRANT , Marinus Karel Johannes DE JAGER
IPC分类号： G01N33/68
摘要： Disclosed is an in vitro method for assessing or predicting the response of a human patient to treatment of periodontal disease. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva of a patient, the concentrations are measured of certain protein combinations. One such combination is Alpha-1-acid glycoprotein (A1AGP) and at least one of Interleukin-1-beta (I-1β) and 5 Matrix metalloproteinase-8 (MMP-8). Based on the concentrations as measured, at least one value is determined reflecting the joint concentrations for said proteins. This at least one value may indicate the probability that human patient has been or will be successfully treated for the periodontitis. The at least one value can be compared with at least one threshold value reflecting in the same manner the joint concentrations associated with successful treatment of 10 periodontitis. The comparison allows assessing whether the testing value is indicative of the periodontal treatment status in said patient.
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