公开(公告)号：US20130315839A1

公开(公告)日：2013-11-28

申请号：US13956245

申请日：2013-07-31

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Chulhyun LEE ,  Sung Lan JEON ,  Min Kyung CHAE ,  Jee-Hyun CHO ,  Eun Ju JANG

IPC: A61B5/055 ,  A61K9/51

CPC classification number: A61B5/055 ,  A61K9/51 ,  A61K9/5115 ,  A61K49/1836 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C01G49/04 ,  C01G49/08 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/34 ,  C01P2004/64 ,  C09C1/24 ,  Y10S977/773 ,  Y10S977/788 ,  Y10S977/81 ,  Y10S977/906 ,  Y10S977/93

Abstract: Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron oxide nano contrast agents can be prepared by the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe3O4 nanoparticles having an interior space.

Abstract translation: 公开了具有优异T2对比效果的磁共振成像用氧化铁纳米造影剂，也可用作药物的储存或载体等。 氧化铁纳米对比剂可以通过以下步骤制备：用有机溶剂中的选自聚乙二醇 - 磷脂缀合物，葡聚糖，壳聚糖，二巯基琥珀酸及其混合物的涂层材料涂覆疏水性FeO纳米颗粒的表面， 形成具有亲水表面和在水中分散性的亲水性FeO纳米颗粒; 将亲水性FeO纳米颗粒分散在水中以氧化FeO; 并将氧化的亲水性FeO纳米颗粒暴露于酸性缓冲液以溶解和除去内部未氧化的FeO部分，从而形成具有内部空间的Fe 3 O 4纳米颗粒。