公开(公告)号：US20180303889A1

公开(公告)日：2018-10-25

申请号：US15572062

申请日：2015-09-30

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： No Soo KIM ,  Jong-Shik PARK ,  Jin-Mu YI ,  You Jin LEE ,  Eun-Sang CHO ,  Jinhee KIM ,  Chae Jun LIM ,  Ok-Sun BANG ,  Youngah KIM

IPC: A61K36/30 ,  A61P25/02

CPC classification number: A61K36/30 ,  A61K31/282 ,  A61K31/337 ,  A61K2300/00 ,  A61P25/02

Abstract: A composition comprising a Lithospermi Radix extract as an effective component prevents, alleviates, or treats peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy). A method for preventing or treating peripheral neuropathy includes administering to a subject in need thereof the composition. The Lithospermi Radix extract can relieve the suppressed growth of neurites caused by an anti-cancer agent while neither inducing any cytotoxicity in normal cells nor changing the unique cytotoxic potential of an anti-cancer agent in human cancer cells. In addition, the Lithospermi Radix extract can efficiently lower the enhanced sensitivity to painful stimuli in peripheral neuropathic animals induced by an anti-cancer agent. Thus, the Lithospermi Radix extract can be advantageously used as an effective component of a composition for prevention, alleviation, or treatment of chemotherapy-induced peripheral neuropathy.