公开(公告)号：US20210205398A1

公开(公告)日：2021-07-08

申请号：US15999722

申请日：2017-02-17

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jinhee KIM ,  Eun Sang CHO ,  No Soo KIM ,  Ok-Sun BANG ,  You Jin LEE ,  Young-Ah KIM ,  Eunna HUH

IPC: A61K36/899 ,  A61P7/06 ,  A23L33/105 ,  A23L33/00

Abstract: A composition contains Phragmitis Rhizoma extract as an active ingredient. As a result of treating mouse bone marrow cells with an extract of Phragmitis Rhizoma, it was confirmed to have an effect that a decrease in colony of hematopoietic cells, which is induced by an anticancer agent, is significantly recovered and bone marrow suppression caused by an anticancer agent is significantly recovered in an animal model which has been induced to have bone marrow suppression according to intraperitoneal injection of an anticancer agent. Thus, the Phragmitis Rhizoma extract can be advantageously used for a composition for prevention, amelioration, or treatment of a disorder caused by side effect of an anticancer agent, and there is a possibility of having the increased effect of an anticancer agent when it is used as an anticancer adjuvant in combination with an anticancer agent.

公开(公告)号：US20180303889A1

公开(公告)日：2018-10-25

申请号：US15572062

申请日：2015-09-30

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： No Soo KIM ,  Jong-Shik PARK ,  Jin-Mu YI ,  You Jin LEE ,  Eun-Sang CHO ,  Jinhee KIM ,  Chae Jun LIM ,  Ok-Sun BANG ,  Youngah KIM

IPC: A61K36/30 ,  A61P25/02

CPC classification number: A61K36/30 ,  A61K31/282 ,  A61K31/337 ,  A61K2300/00 ,  A61P25/02

Abstract: A composition comprising a Lithospermi Radix extract as an effective component prevents, alleviates, or treats peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy). A method for preventing or treating peripheral neuropathy includes administering to a subject in need thereof the composition. The Lithospermi Radix extract can relieve the suppressed growth of neurites caused by an anti-cancer agent while neither inducing any cytotoxicity in normal cells nor changing the unique cytotoxic potential of an anti-cancer agent in human cancer cells. In addition, the Lithospermi Radix extract can efficiently lower the enhanced sensitivity to painful stimuli in peripheral neuropathic animals induced by an anti-cancer agent. Thus, the Lithospermi Radix extract can be advantageously used as an effective component of a composition for prevention, alleviation, or treatment of chemotherapy-induced peripheral neuropathy.