公开(公告)号：US11191801B2

公开(公告)日：2021-12-07

申请号：US15313341

申请日：2015-05-21

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim ,  Eunjin Shon ,  Yun Mi Lee ,  Sojin Choi ,  Ik Soo Lee ,  Young Sook Kim ,  Dong Ho Jung ,  Bo-Jeong Pyun ,  Seung-Hyun Jung

IPC: A61K36/54 ,  A61K36/65

Abstract: The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, have an excellent effect in inhibiting the generation of the advanced glycation end-products in a human retinal pigment epithelial cell line subjected to a hyperglycemic or aging environment, and have excellent effects in delaying, preventing, and treating diabetic complications, muscular degeneration, commotio retinae, and lower extremity edema in various animal models of diabetic complications, macular degeneration, and lower extremity edema, and thus the mixture extract can effectively be used as an active ingredient for a composition for preventing and treating diabetic complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, and angioedema, including macular (retinal) edema, macular degeneration, and varicose veins.

公开(公告)号：US10537603B2

公开(公告)日：2020-01-21

申请号：US15313654

申请日：2015-05-21

Applicant: Korea Institute of Oriental Medicine

Inventor： Jin Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim ,  Eunjin Shon ,  Yun Mi Lee ,  Young Sook Kim ,  Sojin Choi ,  Ik Soo Lee ,  Dong Ho Jung ,  Bo-Jeong Pyun ,  Seung-Hyun Jung

IPC: A61K36/65 ,  A61K36/484

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating angioedema, containing as an active ingredient a peony root extract or an extract of a mixture of peony root and licorice. In particular, the extract of a mixture of peony root and licorice according to the present invention inhibits the excessive generation of advanced glycation end products, which may cause macular degeneration, inhibits blood-retinal barrier breakdown causing retinal edema in various animal models, protects or treats a subretinal region causing dry macular degeneration, inhibits angiogenesis causing wet macular degeneration, and thus can be usefully used as an active ingredient for the composition for preventing and treating angioedema including macular degeneration, macular edema, retinal edema, or varicose veins.