公开(公告)号：US11484562B2

公开(公告)日：2022-11-01

申请号：US17040447

申请日：2018-12-11

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook Kim ,  Chan-Sik Kim ,  Ik Soo Lee ,  Gyu Hyung Jo ,  Soo-Wang Hyun

IPC: A61K36/65 ,  A23L33/00 ,  A23L33/105 ,  A61P3/04 ,  A61K36/54

Abstract: Provided is a composition for preventing or treating obesity including a mixed extract of Cinnamomi twigs, and more particularly, a pharmaceutical composition for preventing or treating obesity including a mixed extract of Cinnamomi twigs and Moutan root bark, a health functional food composition of feed composition for preventing or alleviating obesity including the composition, and a method of preventing or treating obesity including administering the pharmaceutical composition to an individual having obesity or a risk of developing obesity. The mixed extract of Cinnamomi twigs and Moutan root bark may inhibit fat absorption in the intestinal tract and increases in body weight causing obesity by single-dose administration, reduce lipid content in the blood, decrease weight and size of adipocytes, effectively inhibit accumulation of fat in liver tissue, and inhibit diarrhea, a serious side effect of Xenical™, by long-term administration.

公开(公告)号：US11191801B2

公开(公告)日：2021-12-07

申请号：US15313341

申请日：2015-05-21

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim ,  Eunjin Shon ,  Yun Mi Lee ,  Sojin Choi ,  Ik Soo Lee ,  Young Sook Kim ,  Dong Ho Jung ,  Bo-Jeong Pyun ,  Seung-Hyun Jung

IPC: A61K36/54 ,  A61K36/65

Abstract: The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, have an excellent effect in inhibiting the generation of the advanced glycation end-products in a human retinal pigment epithelial cell line subjected to a hyperglycemic or aging environment, and have excellent effects in delaying, preventing, and treating diabetic complications, muscular degeneration, commotio retinae, and lower extremity edema in various animal models of diabetic complications, macular degeneration, and lower extremity edema, and thus the mixture extract can effectively be used as an active ingredient for a composition for preventing and treating diabetic complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, and angioedema, including macular (retinal) edema, macular degeneration, and varicose veins.

公开(公告)号：US10537603B2

公开(公告)日：2020-01-21

申请号：US15313654

申请日：2015-05-21

Applicant: Korea Institute of Oriental Medicine

Inventor： Jin Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim ,  Eunjin Shon ,  Yun Mi Lee ,  Young Sook Kim ,  Sojin Choi ,  Ik Soo Lee ,  Dong Ho Jung ,  Bo-Jeong Pyun ,  Seung-Hyun Jung

IPC: A61K36/65 ,  A61K36/484

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating angioedema, containing as an active ingredient a peony root extract or an extract of a mixture of peony root and licorice. In particular, the extract of a mixture of peony root and licorice according to the present invention inhibits the excessive generation of advanced glycation end products, which may cause macular degeneration, inhibits blood-retinal barrier breakdown causing retinal edema in various animal models, protects or treats a subretinal region causing dry macular degeneration, inhibits angiogenesis causing wet macular degeneration, and thus can be usefully used as an active ingredient for the composition for preventing and treating angioedema including macular degeneration, macular edema, retinal edema, or varicose veins.

公开(公告)号：US09844575B2

公开(公告)日：2017-12-19

申请号：US14759471

申请日：2014-01-10

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook Kim ,  Jung Hyun Kim ,  Chan Sik Kim ,  Young Sook Kim ,  Eun Jin Shon ,  Yun Mi Lee ,  Dong Ho Jung ,  Ik Soo Lee ,  Gyu Hyeong Jo ,  Joo Hwan Kim

IPC: A61K36/00 ,  A61K36/25 ,  A61K31/155 ,  A61K36/708 ,  A61K36/488 ,  A61K36/16 ,  A61K36/482 ,  A61K36/45 ,  A61K36/73 ,  A61K36/87 ,  A61K36/718 ,  A23L33/105

CPC classification number: A61K36/25 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/155 ,  A61K36/16 ,  A61K36/45 ,  A61K36/482 ,  A61K36/488 ,  A61K36/708 ,  A61K36/718 ,  A61K36/73 ,  A61K36/87 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen, blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.