公开(公告)号：US20210202039A1

公开(公告)日：2021-07-01

申请号：US17139031

申请日：2020-12-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Keunwan PARK ,  Cheol-Ho PAN ,  Moon-Hyeong SEO ,  Dae-geun SONG ,  Chulhee KWAK

IPC: G16B30/10

Abstract: The present invention relates to a method for designing an optimized mutant protein sequence using amino acid co-evolutionary information. Specifically, the present invention relates to a method for searching a protein having a novel mutant sequence with improved expression level, water solubility, stability, and functionality, while maintaining the original function of the protein, using amino acid co-evolutionary information and information on protein tertiary structure.