公开(公告)号：US20230250424A1

公开(公告)日：2023-08-10

申请号：US16761151

申请日：2018-10-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Sang Hoon JUNG ,  Young-Joo KIM ,  Dae-geun SONG ,  Young Nyun PARK ,  Jeong Eun YOO ,  Hyung Jin RHEE ,  Youngsic JEON

IPC: C12N15/113 ,  A61P35/00 ,  A61P1/16

CPC classification number: C12N15/113 ,  A61P1/16 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/127 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2310/3181

Abstract: In the present specification, on the basis of the correlation between prospero homeobox protein 1 (PROX1) and telomerase reverse transcriptase (TERT), a composition for regulating expression of TERT, a method for screening a TERT expression regulator, a composition for diagnosing a TERT expression status, a diagnostic kit, a method for providing information for diagnosis, or a method for providing information for cancer diagnosis are disclosed. Specifically, in one aspect, the PROX1 of the present disclosure may bind to a TERT promoter, in particular a mutant TERT promoter in which base substitution occurs at the -124 or -146 bp position to regulate the expression of TERT, and the expression of TERT in non-hepatitis B virus-associated liver cancer can be inhibited specifically among liver cancers.

公开(公告)号：US20200009172A1

公开(公告)日：2020-01-09

申请号：US16212116

申请日：2018-12-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  REPUBLIC OF KOREA(MANAGEMENT : RURAL DEVELOPMENT ADMINISTRATION)

Inventor： Yongsoo CHOI ,  Jin-Chul KIM ,  Su-Nam KIM ,  Kyungsu KANG ,  Seung-Hoon YANG ,  Keunwan PARK ,  Hee Ju LEE ,  Dae-geun SONG ,  Kwang-Hyun CHA ,  Joo Yeong JEON ,  Chang Geon KIM ,  Jung Kyung MOON ,  Man Soo CHOI ,  Soo Kwon PARK ,  Nam Hee JEONG

IPC: A61K31/7048 ,  A61K31/352 ,  A61K36/48 ,  A61P17/00 ,  A61P29/00 ,  A61K9/00 ,  A23L33/105

Abstract: Provided are a composition for preventing or improving inflammation, the composition including an extract of a seed of soybean Glycine max (L.) Merrill cultivar SCEL-1, and a method of preventing occurrence of inflammation in a subject or improving inflammation in a subject, the method including injecting the composition to a subject.

公开(公告)号：US20250099390A1

公开(公告)日：2025-03-27

申请号：US18730898

申请日：2023-01-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ki Young CHOI ,  Kwang-Hyun CHA ,  Hwa Seung HAN ,  Jin Soo PARK ,  Dae-geun SONG ,  Myung Suk KIM ,  Hak Cheol KWON

IPC: A61K9/50 ,  A61K35/74 ,  A61K35/745 ,  A61P37/06

Abstract: Provided is a method for preventing, ameliorating, or treating inflammatory diseases by administering a composition containing extracellular vesicles (EVs) derived from Roseburia spp. strains and/or Bifidobacterium spp. strains, wherein the EVs exhibits effectiveness in improving inflammatory bowel disease (IBD), and additionally, all EVs derived from congeneric strains corresponding to Roseburia spp. strains or Bifidobacterium spp. strains. have been confirmed to exhibit strong anti-inflammatory effect, and the strains and EVs derived therefrom can be provided as a composition for preventing, ameliorating, or treating a variety of inflammatory diseases.

公开(公告)号：US20210202039A1

公开(公告)日：2021-07-01

申请号：US17139031

申请日：2020-12-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Keunwan PARK ,  Cheol-Ho PAN ,  Moon-Hyeong SEO ,  Dae-geun SONG ,  Chulhee KWAK

IPC: G16B30/10

Abstract: The present invention relates to a method for designing an optimized mutant protein sequence using amino acid co-evolutionary information. Specifically, the present invention relates to a method for searching a protein having a novel mutant sequence with improved expression level, water solubility, stability, and functionality, while maintaining the original function of the protein, using amino acid co-evolutionary information and information on protein tertiary structure.