公开(公告)号：US20220251170A1

公开(公告)日：2022-08-11

申请号：US17712155

申请日：2022-04-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-ee KOH ,  Eun Jung LEE ,  Yoo Soo YANG ,  In-San KIM

IPC: C07K14/71 ,  A61P35/00 ,  C12N9/12

Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface of the exosome.

公开(公告)号：US20220409550A1

公开(公告)日：2022-12-29

申请号：US17843418

申请日：2022-06-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： In-San KIM ,  Eun Jung LEE ,  Gi-hoon NAM ,  Gi-beom KIM ,  Hyo-Dong SUNG

IPC: A61K9/51 ,  C07K14/79 ,  A61P35/00

Abstract: Provided are a programmed cell death protein 1 (PD-1)-decorated nanocage and use thereof. The PD-1-decorated nanocage (PdNC) of the present disclosure may block PD-1 and programmed cell death-ligand (PD-L) signaling and may induce anti-tumor immunity activation at two immune checkpoints of tumor microenvironment (TME) (effector phase) and tumor-draining lymph node (TDLN) (innate phase), thereby increasing the adaptability of PD-1 and PD-L blockade-based therapy. Accordingly, it may be applied to various kinds of cancer therapies.

公开(公告)号：US20200148746A1

公开(公告)日：2020-05-14

申请号：US16475052

申请日：2017-12-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-ee KOH ,  Eun Jung LEE ,  Yoo Soo YANG ,  In-San KIM

IPC: C07K14/71 ,  C12N9/12 ,  A61P35/00

Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention privides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface thereof.

公开(公告)号：US20210054047A1

公开(公告)日：2021-02-25

申请号：US17013245

申请日：2020-09-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Min-Woo KIH ,  Eun Jung LEE ,  Yoo Soo YANG ,  Cherl Hyun JEONG ,  In-San KIM ,  Soyoun KIM

IPC: C07K14/705 ,  A61P35/00

Abstract: The present invention relates to a novel anticancer fusion protein and use thereof, and more particularly, provides a fusion protein in which a tumor necrosis factor (TNF) superfamily protein is linked to a self-assembled protein, which is capable of forming a protein nanocage by self-assembly of the self-assembled protein.