公开(公告)号：US20210015931A1

公开(公告)日：2021-01-21

申请号：US16573351

申请日：2019-09-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Hwa KIM ,  Ick Chan KWON ,  In-San KIM ,  Kwangmeyung KIM ,  Yoosoo YANG ,  Young-Ji KO

IPC: A61K47/55 ,  A61K47/54 ,  A61K31/713 ,  A61P35/00 ,  C12N15/113 ,  C07K14/705

Abstract: A fusion protein-siRNA complex according to the present disclosure binds specifically to cancer cells, is taken up effectively by the cells, and exhibits anticancer activity as it is degraded by lysosomes. The fusion protein-siRNA complex provides maximized anticancer activity so that the cancer cells can be removed by autoimmunity, by inhibiting the immunity of the cancer cells and enhancing phagocytosis by macrophages.

公开(公告)号：US20200148746A1

公开(公告)日：2020-05-14

申请号：US16475052

申请日：2017-12-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-ee KOH ,  Eun Jung LEE ,  Yoo Soo YANG ,  In-San KIM

IPC: C07K14/71 ,  C12N9/12 ,  A61P35/00

Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention privides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface thereof.

公开(公告)号：US20190016764A1

公开(公告)日：2019-01-17

申请号：US15757580

申请日：2016-09-02

Applicant: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jong-Sup BAE ,  In-San KIM ,  Won Hwa LEE ,  Jun Young SEO ,  So Youn KIM

IPC: C07K14/47 ,  C07K14/79 ,  C12N15/62 ,  A61P29/00 ,  C07K14/54 ,  A61K47/64

CPC classification number: C07K14/47 ,  A61K38/16 ,  A61K38/17 ,  A61K38/2006 ,  A61K38/2026 ,  A61K38/2073 ,  A61K38/2086 ,  A61K38/40 ,  A61K47/644 ,  A61P29/00 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/5431 ,  C07K14/5437 ,  C07K14/79 ,  C07K19/00 ,  C12N15/62 ,  Y02A50/40

Abstract: The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound; and a pharmaceutical composition for treating inflammatory diseases, containing the same as an active ingredient and, more specifically, to: a fusion polypeptide in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a ferritin monomer fragment from which a portion of a fourth loop and a fifth helix, of a human derived ferritin monomer, are removed; and a use thereof for treating inflammatory diseases. As in the above, the fusion polypeptide, which has an amino acid sequence represented by SEQ ID NO: 1 and in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a fragment of a human-derived ferritin monomer, can fuse two types of anti-inflammatory polypeptides, acting through different mechanisms, into a nano cage and administer the same, and thus the fusion polypeptide can exhibit an excellent effect in the treatment of inflammatory diseases including sepsis.

公开(公告)号：US20220251170A1

公开(公告)日：2022-08-11

申请号：US17712155

申请日：2022-04-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-ee KOH ,  Eun Jung LEE ,  Yoo Soo YANG ,  In-San KIM

IPC: C07K14/71 ,  A61P35/00 ,  C12N9/12

Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface of the exosome.

公开(公告)号：US20180291072A1

公开(公告)日：2018-10-11

申请号：US15756988

申请日：2016-09-02

Applicant: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Youn KIM ,  Gwang-Seob KIM ,  Jun Young SEO ,  In-San KIM

IPC: C07K14/47 ,  A61K47/64 ,  C07K19/00 ,  A61K49/00 ,  C07K14/435

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K38/1709 ,  A61K47/64 ,  A61K47/65 ,  A61K49/0047 ,  A61K49/0056 ,  C07K14/43595 ,  C07K14/79 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/60

Abstract: Disclosed are a human-derived ferritin monomer fragment and a fusion polypeptide using the same, and more particularly, to a human-derived ferritin of which a portion of a fourth loop and a fifth helix of the ferritin monomer fragment are removed, and a fusion polypeptide in which a polypeptide or a protein is fused to an N-terminus or a C-terminus of the ferritin monomer fragment.

公开(公告)号：US20180028600A1

公开(公告)日：2018-02-01

申请号：US15650272

申请日：2017-07-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yeon-Sun HONG ,  Yoo Soo YANG ,  Cherl Hyun JEONG ,  In-San KIM

IPC: A61K38/16 ,  A61K45/06 ,  A61K9/127

CPC classification number: A61K38/162 ,  A61K9/1271 ,  A61K45/06 ,  A61P3/10 ,  A61P21/00

Abstract: Provided is a recombinant exosome, and more specifically, to a recombinant exosome obtained from a eukaryotic cell transfected for the expression of a glucose transporter protein (GLUT) and a membrane fusogenic protein, and use thereof.

公开(公告)号：US20240358645A1

公开(公告)日：2024-10-31

申请号：US18652504

申请日：2024-05-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yeon-Sun HONG ,  Yoo Soo YANG ,  In-San KIM

IPC: A61K9/48 ,  A61K31/337 ,  A61K31/407 ,  A61K31/704 ,  A61K38/47 ,  A61K39/395 ,  A61K41/00 ,  A61K45/06 ,  A61N5/10 ,  A61P35/00

CPC classification number: A61K9/48 ,  A61K31/337 ,  A61K31/407 ,  A61K31/704 ,  A61K38/47 ,  A61K39/3955 ,  A61K41/0057 ,  A61K45/06 ,  A61P35/00 ,  C12Y302/01035 ,  A61N5/10 ,  A61N2005/1098

Abstract: The present invention relates to a recombinant exosome containing hyaluronidase and a use thereof, and more particularly to a recombinant exosome that presents hyaluronidase on its surface and use thereof as an anticancer agent.

公开(公告)号：US20240050523A1

公开(公告)日：2024-02-15

申请号：US18447152

申请日：2023-08-09

Applicant: SHIFTBIO INC. ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gi-Hoon NAM ,  Gi Beom KIM ,  Jae Hyun KIM ,  Yeji LEE ,  Jiyoung GOO ,  Seongeun CHO ,  Cherlhyun JEONG ,  In-San KIM

IPC: A61K38/17 ,  A61K9/127 ,  A61K47/65 ,  A61P1/16 ,  A61P29/00 ,  A61K47/69 ,  A61K47/64

CPC classification number: A61K38/1709 ,  A61K9/127 ,  A61K38/177 ,  A61K47/65 ,  A61P1/16 ,  A61P29/00 ,  A61K47/6911 ,  A61K47/64

Abstract: The present invention generally relates to an extracellular vesicle (EV) comprising a subunit of a heterodimeric transcription factor, an EV polypeptide, and a monomeric cis-cleaving intein and a method of using the EV.

公开(公告)号：US20210054047A1

公开(公告)日：2021-02-25

申请号：US17013245

申请日：2020-09-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Min-Woo KIH ,  Eun Jung LEE ,  Yoo Soo YANG ,  Cherl Hyun JEONG ,  In-San KIM ,  Soyoun KIM

IPC: C07K14/705 ,  A61P35/00

Abstract: The present invention relates to a novel anticancer fusion protein and use thereof, and more particularly, provides a fusion protein in which a tumor necrosis factor (TNF) superfamily protein is linked to a self-assembled protein, which is capable of forming a protein nanocage by self-assembly of the self-assembled protein.

公开(公告)号：US20230226215A1

公开(公告)日：2023-07-20

申请号：US17937437

申请日：2022-09-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  REONEBIO

Inventor： In-San KIM ,  Gi-Hoon NAM ,  Yeon-Sun HONG ,  Seong Eon CHO

IPC: A61K47/69 ,  A61K38/18 ,  A61K38/17 ,  A61K35/28 ,  A61P17/02 ,  A61K9/06

CPC classification number: A61K47/6911 ,  A61K38/1808 ,  A61K38/179 ,  A61K38/1796 ,  A61K38/177 ,  A61K38/1774 ,  A61K35/28 ,  A61P17/02 ,  A61K9/06

Abstract: The present invention provides a recombinant exosome comprising a membrane-bound EGF protein on the surface of the recombinant exosome and provides a use of the recombinant exosome.